A5100330077- Extracellular vesicles in disease
- MicroRNA in disease regulation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
- Natural Compounds in Disease Treatment
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Sphingolipid Metabolism and Signaling
- Autoimmune and Inflammatory Disorders Research
- Fungal Biology and Applications
- Glutathione Transferases and Polymorphisms
- Plant biochemistry and biosynthesis
- Heat shock proteins research
- Psoriasis: Treatment and Pathogenesis
- Circular RNAs in diseases
- Nanopore and Nanochannel Transport Studies
- Anodic Oxide Films and Nanostructures
- GDF15 and Related Biomarkers
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
Macau University of Science and Technology
2016-2025
Second Xiangya Hospital of Central South University
2024-2025
Central South University
2023-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Zhongda Hospital Southeast University
2021-2023
National Clinical Research
2023
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
Shenzhen Institutes of Advanced Technology
2021
Chinese Academy of Sciences
2021
Celastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca
The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, and RA pathogenesis remain unexplored. Here we show that accumulation fragments, age regulated by exonuclease TREX1, promotes abnormal activation immune system an adjuvant-induced (AIA) rat model. Local overexpression TREX1 suppresses synovial inflammation rats, while conditional genomic deletion AIA rats result...
Alterations in histone modification have been linked to cancer development and progression. Celastrol, a Chinese herbal compound, shows potent anti-tumor effects through multiple signaling pathways. However, the involvement of modifications this process has not yet illustrated. In study, barcode sequencing eukaryotic genome-wide deletion library revealed that modifications, especially acetylation associated with NuA4 acetyltransferase complex, were involved anti-proliferation actions...
Blockade of immune checkpoints as a strategy cancer cells to overcome the response has received ample attention in research recently. In particular, expression PD-L1 by various become paradigm this respect. Delivery its site action occurs either local diffusion, or else transport via small extracellular vesicles (sEVs, commonly referred exosomes). Many steps sEVs formation, their packaging with and release into space have been studied detail. The likely dependence on Ca2+ -signaling,...
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects mass remain unclear. In our present study, we observed that (CT) decreased and quality in mice. Furthermore, a transplant of exosomes derived from plasma mice exposed (CT-EXO) can also impair osteogenic differentiation BMSCs decrease inhibiting autophagic activity. Rapamycin, potent inducer autophagy, reverse or CT-EXO-induced loss. Microarray sequencing...
Small extracellular vesicles (sEVs), carrying PD-L1, have been implicated in immune evasion and tumor progression. However, understanding how PD-L1 sEVs are secreted still needs to be improved. We found that the secretion dynamics of is similar other sEVs. Intracellular calcium associated downstream PKC signaling plays pivotal roles releasing non-small cell lung cancer cells (NSCLC). Particularly, we observed knocking down PKCα has profound impacts on secretion, especially resting state...
Drug resistance is becoming an obstacle in anti-cancer therapies. For target-based therapy of lung cancer, gefitinib, as the first generation tyrosine kinase inhibitors (TKIs), demonstrated good initial response to non-small cell cancer (NSCLC) patients whom harbors epidermal growth factor receptor (EGFR) mutation. However, within one year, additional EGFR mutation occurred, leading eventual gefitinib-resistance. Therefore, it urgently discover novel effective small molecule for those...
The survival time of patients with leptomeningeal metastasis (LM) lung cancer is very short, and the clinical characteristics LM are varied, making diagnosis difficult. At present, a positive CSF fluid (CSF) cytology result remains gold standard for diagnosing in cancer; however, process collecting traumatic far less convenient than blood collection. With development technology, an increasing number studies prefer to use liquid biopsy diagnose or predict occurrence disease. Therefore, we...
Far-infrared radiation (FIR) is widely used in the treatment of various diseases such as insomnia and cardiovascular risk. Rheumatoid arthritis (RA) a chronic systemic autoimmune disease which therapeutic potential FIR RA unclear. To determine mechanistic actions RA. Adjuvant-induced (AIA) rat models were established to assess potency treatment. The scoring parameters score, swelling hind paw, spleen thymus indices, micro-CT analysis indices adopted estimate beneficial effects during AIA...
Aging is the leading cause of several degenerative diseases. Photoaging due to ultraviolet (UV) exposure accounts for more than 80% facial aging, which a complex and incompletely understood process. Here, we explored mechanisms skin photoaging increased chromatin accessibility in UVB-irradiated human dermal fibroblasts (UVB-HDFs). Especially, investigated key pathways inflammatory responses characterized by exons occupied active repressive marks. mRNA sequencing revealed changes expression...
Background The functions and related signal pathways of the IFIT3 gene in skin lesions patients with psoriasis were explored through bioinformatics methods to determine potential specific molecular markers psoriasis. Methods “limma” R package was used analyze three datasets from Gene Expression Omnibus database (GSE13355, GSE30999 GSE106992), differential genes screened. STRING for ontology (GO) enrichment analysis, Kyoto encyclopedia genomes (KEGG) pathway protein–protein interaction...
Extracellular vesicles (EVs) transport proteins, signaling lipids, and nucleic acids from donor cells to recipient cells, therefore have been verified serve as mediators of intercellular communications. EV-resident RNAs widely used biomarkers disease prognostic indicators. Thus, in situ extraction a microfluidic flow is great importance for developing integrated microsystems realize on-chip PCR. This paper presents silicon-based device solid-phase RNAs. The contains micro-pillar arrays...
Background: Hypertension induced cardiac hypertrophy is one of the most common pre-diseases heart failure. This study aimed to identify key pathogenic genes in process disease. Methods: GSE18224 was re-analyzed and obtained differentially expressed (DEGs). Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis were carried out. Networks transcription factor (TF)-mRNA, microRNA (miRNA)-mRNA Protein-Protein interaction (PPI) constructed, module further screened out from PPI...
<p>PDF file - 69K</p>
<p>PDF file - 69K</p>
Abstract Medial arterial calcification (MAC), a systemic vascular disease different from atherosclerosis, is associated with an increased incidence of cardiovascular events. Several studies have demonstrated that ambient temperature one the most important factors affecting However, there has been limited research on effect temperatures MAC. In present study, we showed compared room exposure (RT), cold (CT) in mice decreased vitamin D (VD)-induced calcification. To investigate mechanism...
Extracellular vesicles (EVs) are membranous released by a variety of cells and involved in intercellular communication disease progression. Exosomes, subset EVs with 30-150 nm diameter, have recently drawn much attention research. that directly originate from urine good indicators diseases the urinary system favor urological studies. Dithiothreitol (DTT) is widely used to reduce contamination Tamm-Horsefall protein (THP), which most abundant human greatest challenge isolation EVs....
Extracellular vesicles (EVs) are membranous released by various cells, and involved in intercellular communication disease progression. EVs that isolated from urine good indicators of urinary system diseases help certain urological studies. During isolation EVs, Dithiothreitol (DTT) is widely used to reduce the contamination major contaminant Tamm-Horsefall protein (THP),which most abundant human difficult remove EVs. Unfortunately, DTT can interfere with subsequent analysis due its strong...
Abstract Ageing is an unavoidable process in humans and a major factor for the increasing risk of various diseases. In United States, more than 50% rheumatoid arthritis patients are middle-aged or elderly, but factors mechanisms by which ageing increases incidence not known. It has been suggested that accumulation DNA fragments autoimmune diseases, such as systemic lupus erythematosus. common nucleic acid metabolite organisms well serum animals with arthritis; therefore, we hypothesize one...