A5100663264- Neurological Disease Mechanisms and Treatments
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Ion channel regulation and function
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Glycosylation and Glycoproteins Research
- Plant-based Medicinal Research
- Electrolyte and hormonal disorders
- Traditional Chinese Medicine Studies
- Adenosine and Purinergic Signaling
- Congenital Diaphragmatic Hernia Studies
- Salivary Gland Disorders and Functions
- Bacterial Infections and Vaccines
- Brucella: diagnosis, epidemiology, treatment
- Heat shock proteins research
- Genetic Mapping and Diversity in Plants and Animals
- Heme Oxygenase-1 and Carbon Monoxide
- Cytokine Signaling Pathways and Interactions
Changzhou No.2 People's Hospital
2021
Nanjing Medical University
2021
Macau University of Science and Technology
2021
China Medical University
2013-2019
Lanzhou University
2019
Lanzhou University Second Hospital
2019
First Hospital of China Medical University
2019
Third Affiliated Hospital of Guangzhou Medical University
2014-2016
Fudan University
2016
Zhongshan Hospital
2016
Objective . Tofacitinib is a novel therapy for rheumatoid arthritis (RA). The aim of this study was to measure various serum cytokines levels and explore potential markers predictive therapeutic efficacy tofacitinib RA patients. Methods Thirty-two patients with were given (5 mg bid). Serum Th1 (IFN- γ ), Th2 (IL-6), Th17 (IL-17), Tregs (IL-35), TNF- α detected by enzyme-linked immunosorbent assays. Results Disease activity significantly decreased as early week 4 after treatment. IL-35...
// Yi Fang 1,2,3,* , Hui Zhang 1,4,* Yihong Zhong 1 and Xiaoqiang Ding 1,2,3 Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China 2 Shanghai Institute Kidney Dialysis, 3 Key Laboratory Blood Purification, 4 The Affiliated Hospital Qingdao Qingdao, * These authors have contributed equally to this work Correspondence to: Ding, email: Keywords : prolyl hydroxylase 2; hypoxia inducible factor; renal ischemia-reperfusion injury; autophagy apoptosis; Pathology Section...
Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the damage due I/R injury. Our previous study showed activation dopamine D3 receptor (D3R) increased its linkage with Gα12, hampered Gα12-mediated stimulation sodium transport. In present study, we used an in-vivo rat model in vitro epithelial cell line (NRK52E) investigate whether or not between D3R...
Far-infrared radiation (FIR) is widely used in the treatment of various diseases such as insomnia and cardiovascular risk. Rheumatoid arthritis (RA) a chronic systemic autoimmune disease which therapeutic potential FIR RA unclear. To determine mechanistic actions RA. Adjuvant-induced (AIA) rat models were established to assess potency treatment. The scoring parameters score, swelling hind paw, spleen thymus indices, micro-CT analysis indices adopted estimate beneficial effects during AIA...
Poststroke seizures are considered to be the major cause of epilepsy in elderly. The mechanisms poststroke remain unclear. A history diabetes mellitus has been identified as an independent predictor acute stroke patients. present study sought reveal for development postischemic under hyperglycemic conditions. Transient forebrain ischemia was produced adult Wistar rats by using four‐vessel occlusion method. At normal blood glucose level, occurred ∼50% after 25 min ischemia. However, with...
To study the timing of infusion hypertonic saline solution (HTS) to exert its protective effect on intestinal barrier function in rabbits with ischemia/reperfusion (I/R) injury.Seventy-two were randomly divided into four groups (each n=18): sham operation group, I/R HTS pretreatment group and delayed treatment group. The models produced by blocking superior mesenteric artery (SMA) for 1 hour followed release SMA. 7.5% (6 ml/kg) was infused 5 minutes before SMA, 2 hours after reperfusion...
<h3>Background:</h3> Rheumatoid arthritis (RA) is a common chronic systemic autoimmune diseases characterized by the inflammation in joint and synovium. Synovitis leads to destruction of cartilage bone subsequently dysfunction even disability eventually.Recently, IL-25 has been found play role regulating through Th1 Th17 responses inflammatory diseases<sup>[</sup><i><sup>3</sup></i><sup>]</sup>, However, function fibroblast-like synoviocytes its signaling pathway are not clear. This study...
T-cell immunoglobulin and mucin domain-4 (TIMD-4) are likely to impact autoimmune diseases (e.g., rheumatoid arthritis (RA)). It is hypothesized here that TIMD-4 gene polymorphism display a correlation with the RA risk.For examining effect exerted by genetic variant in risk, case-control study containing 379 cases 432 healthy control groups Chinese population was performed. This conducted genotyping use of custom-by-design 48-Plex single nucleotide (SNP) Scan™ Kit. Blood serum conditions...