A5100414426- Extracellular vesicles in disease
- Meat and Animal Product Quality
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Proteins in Food Systems
- Food Quality and Safety Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Infant Nutrition and Health
- Circular RNAs in diseases
- Microencapsulation and Drying Processes
- Gut microbiota and health
- Phagocytosis and Immune Regulation
- Phytochemicals and Antioxidant Activities
- Food composition and properties
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Neurological Disorders and Treatments
- Pediatric health and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Microbial Metabolism and Applications
Tianjin Medical University General Hospital
2017-2025
Tongde Hospital of Zhejiang Province
2023-2025
Capital Medical University
2020-2025
Northeast Agricultural University
2012-2024
Ministry of Education of the People's Republic of China
2017-2024
Qingdao University
2019-2024
Affiliated Hospital of Qingdao University
2019-2024
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Soochow University
2024
Neuronal inflammation is the characteristic pathologic change of acute neurologic impairment and chronic traumatic encephalopathy after brain injury (TBI). Inhibiting excessive inflammatory response essential for improving outcome. To clarify regulatory mechanism microglial exosomes on neu-ronal in TBI, we focused studying impact exosomal miRNAs injured neurons this research. We used a repetitive (r)TBI mouse model harvested extracts from to phase TBI treat cultured BV2 microglia vitro. The...
Exosomes are an emerging candidate for biomarkers of Alzheimer's disease (AD). This study investigated whether exosomal synaptic proteins can predict AD at the asymptomatic stage.We conducted a two-stage-sectional (discovery stage: AD, 28; amnestic mild cognitive impairment [aMCI], 25; controls, 29; validation 73; aMCI, 71; 72), including preclinical (160) and controls (160), confirmation in familial (mutation carriers: 59; non-mutation 62).The concentrations growth associated protein 43...
Repetitive mild traumatic brain injury (rmTBI) is considered to be an important risk factor for long-term neurodegenerative disorders such as Alzheimer's disease, which characterized by β-amyloid abnormalities and impaired cognitive function. Microglial exosomes have been reported involved in the transportation, distribution, clearance of disease. However, their impacts on development neurodegeneration after rmTBI are not yet known. The role miRNAs microglial regulating post-traumatic was...
Increasing evidence has confirmed that the antimicrobial and anti-inflammatory effects of cinnamon essential oil (CEO) contribute to protection against inflammatory bowel disease (IBD). The dextran sodium sulfate (DSS)-induced colitis mouse model was established investigate correlation between protective CEO regulation intestinal microflora. symptoms IBD were assessed by measuring hemoglobin content, myeloperoxidase activity, histopathological observation, cytokines, toll-like receptor...
β-coronaviruses reshape host cell endomembranes to form double-membrane vesicles (DMVs) for genome replication and transcription. Ectopically expressed viral nonstructural proteins nsp3 nsp4 interact zipper bend the ER DMV biogenesis. Genome-wide screens revealed autophagy VMP1 TMEM41B as important factors SARS-CoV-2 infection. Here, we demonstrated that biogenesis, induced by virus infection or expression of nsp3/4, is impaired in KO cells. In cells, nsp3/4 complex forms normally, but...
Macrophages play a key role in silicosis, and exosomes are potent mediators of intercellular communication. This suggests that macrophage-derived have potential contribution to the pathogenesis silicosis. To investigate whether promote or inhibit lung fibrosis, vitro, silica-exposed (SiO
It has been established that maize/soybean intercropping can improve nitrogen use efficiency. However, few studies have addressed how affects nitrogen-fixing bacterial diversity and N fixation efficiency of intercropped soybean. In this study, communities, efficiency, their relationships with soil properties under three fertilization application rates (N0 0 kg/ha, N1 40 N2 80 kg/ha) were explored through field experiments. Nitrogen bacteria assessed using 15N natural abundance, Illumina...
Traumatic brain injury (TBI) can induce systemic coagulopathy and inflammation, thereby increasing the risk of mortality disability. However, mechanism causing inflammation following TBI remains unclear. In prior research, we discovered that brain-derived extracellular vesicles (BDEVs), originating from injured brain, activate coagulation cascade inflammatory cells. this study, primarily investigated how BDEVs affect in peripheral circulation. The results cytokines function indicated lead to...