A5100373102- Alzheimer's disease research and treatments
- Cardiac Imaging and Diagnostics
- Extracellular vesicles in disease
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammasome and immune disorders
- Dementia and Cognitive Impairment Research
- Nitric Oxide and Endothelin Effects
- Coronary Interventions and Diagnostics
- GDF15 and Related Biomarkers
- Cardiovascular Health and Disease Prevention
- Angiogenesis and VEGF in Cancer
- Medicinal Plants and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cerebrovascular and Carotid Artery Diseases
- Sulfur Compounds in Biology
- S100 Proteins and Annexins
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
First Affiliated Hospital of Bengbu Medical College
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
University of Hong Kong
2024
Anhui Medical University
2021-2024
Southeast University
2021-2024
Shandong Academy of Sciences
2023
Qilu University of Technology
2023
Coal Industry Jinan Design & Research Institute (China)
2023
China has a large population of older people, but not yet undertaken comprehensive study on the prevalence, risk factors, and management both dementia mild cognitive impairment (MCI).For this national cross-sectional study, 46 011 adults aged 60 years or were recruited between March 10, 2015, Dec 26, 2018, using multistage, stratified, cluster-sampling method, which considered geographical region, degree urbanisation, economic development status, sex age distribution. 96 sites randomly...
Abstract Introduction Neuronal‐derived exosomal Aβ42, T‐tau, and P‐T181‐tau have been demonstrated to be biomarkers of Alzheimer's disease (AD). However, no study has assessed the association between exosomes CSF. Methods This was a multicenter with two‐stage design. The subjects included 28 AD patients, 25 aMCI 29 controls in discovery stage; results which were confirmed validation stage (73 AD, 71 aMCI, 72 controls). Results concentrations group higher than those control groups (all P <...
Exosomes are an emerging candidate for biomarkers of Alzheimer's disease (AD). This study investigated whether exosomal synaptic proteins can predict AD at the asymptomatic stage.We conducted a two-stage-sectional (discovery stage: AD, 28; amnestic mild cognitive impairment [aMCI], 25; controls, 29; validation 73; aMCI, 71; 72), including preclinical (160) and controls (160), confirmation in familial (mutation carriers: 59; non-mutation 62).The concentrations growth associated protein 43...
Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible STEMI. We conducted randomized study compare the efficacy and safety of PhI half-dose fibrinolytic regimen versus PPCI in STEMI.The EARLY-MYO trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI Acute ST-Segment-Elevation...
Exosomes, a type of extracellular vesicle, have been shown to be involved in many disorders, including Alzheimer's disease (AD). Exosomes may contribute the spread misfolded proteins such as amyloid-β (Aβ) and α-synuclein. However, specific diffusion process exosomes their final destination brain are still unclear. In present study, we isolated from peripheral plasma injected them into hippocampus an AD mouse model, investigated exosome diffusion. We found that can dentate gyrus (DG) other...
Abstract Introduction The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the genetic features of FAD pedigrees and without mutations. Methods In total, 1330 (AD) or mild cognitive impairment 404 were enrolled from Familial Disease Network. mutations APOE frequencies determined. Results 13.12% carried missense mutations, 3.71% synonymous/untranslated region variants, 83.17% did not carry Eleven first identified....
Abstract Background Long intergenic non-coding RNA 00963 (LINC00963) is an oncogenic lncRNA in human cancers. However, little known on how it impacts the pathogenesis of lung adenocarcinoma (LUAD). Methods Biological effects proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) were examined by CCK-8, colony formation, EdU incorporation, transwell, immunofluorescence assays, respectively. Macrophage polarization was evaluated flow cytometry. Ubiquitination Zeb1...
Abstract Introduction The genetic risk effects of apolipoprotein E ( APOE ) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (SAD), and normal controls (NC) remain unclear in the Chinese population. Methods In total, 15 119 subjects, including 311 FAD patients PSEN1, PSEN2, APP, TREM2 , SORL1 pathogenic mutations (FAD [unknown]); 126 PSENs / APP [ PSENs/APP ]); 7234 SAD patients; 7448 NC were enrolled. ε4 analyzed across groups. Results prevalence genotype...
Abstract Background Studies have revealed the association between exosomes and cardiovascular diseases. However, typical changes of plasma miRNAs in patients with atrial fibrillation (AF) are still controversial, use exosomal to diagnose predict prognosis AF has not been described. Hypothesis We hypothesized that there were differences normal sinus rhythm (SR) patients, which might be used as novel biomarkers reflect progression AF. Methods isolated from target genes differential via...
Ventilator-induced lung injury (VILI), one of the most serious complications mechanical ventilation (MV), can impact patients' clinical prognoses. Compared to control ventilation, preserving spontaneous breathing improve many physiological features in ventilated patients, such as gas distribution, cardiac performance, and ventilation-perfusion matching. However, effect on VILI is unknown. The goal this study was compare effects mechanically-ventilated healthy rabbits.Sixteen New Zealand...
Endothelial dysfunction was observed in patients with non-alcoholic fatty liver disease. The aim of the present study to evaluate extent endothelial function impairment disease.We systematically searched through PubMed, Embase, China National Knowledge Infrastructure and Wanfang databases for studies dated up January 2015. All observational that compared between disease healthy controls were included. measured by brachial artery flow-mediated dilation nitrate-induced dilatation...
Abstract The present study was designed to determine whether sulfur dioxide (SO 2 ) could be endogenously produced in adipocyte and served as a novel adipocyte-derived inflammatory inhibitor. SO detected adipose tissue using high-performance liquid chromatography with fluorescence detection. synthase aspartate aminotransferase (AAT1 AAT2) mRNA protein expressions tissues were measured. For vitro study, 3T3-L1 adipocytes cultured, infected adenovirus carrying AAT1 gene or lentivirus shRNA...
Dysfunction of microglia has been increasingly recognized as a causative factor in Alzheimer's disease (AD); thus, developing medicines capable restoring microglial functions is critically important and constitutes promising therapeutic strategy. Honokiol natural neuroprotective compound extracted from Magnolia officinalis, which may play roles AD therapy.This study aimed to evaluate the role underlying mechanisms honokiol phagocytosis.MTT flow cytometry were used assess cell viability...
Abstract Background N-acetylneuraminic acid (Neu5Ac) is a functional metabolite involved in coronary artery disease (CAD). We aimed to evaluate the relationship between serum Neu5Ac and risk prognosis of acute syndrome (ACS) real-world prospective study. Methods Patients with suspected ACS who underwent angiography were included. Serum was measured at admission. Coronary lesion severity evaluated by Gensini Score. GRACE stratification performed Major adverse cardiac events (MACEs) recorded...
It has been proved that spontaneous breathing (SB) with biphasic positive airway pressure (BIPAP) can improve lung aeration in acute respiratory distress syndrome compared controlled mechanical ventilation. The authors hypothesized SB BIPAP would attenuate injury pressure-controlled ventilation.Twenty male New Zealand white rabbits hydrochloric acid aspiration-induced were randomly ventilated using the either (BIPAP plus group) or without minus for 5 h. Inspiration was adjusted to maintain...