A5018928091- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Metabolomics and Mass Spectrometry Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Cholinesterase and Neurodegenerative Diseases
- Cardiovascular Health and Disease Prevention
- Genetic Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Retinal Imaging and Analysis
- Computational Drug Discovery Methods
- Ocular Disorders and Treatments
- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
Capital Medical University
2019-2025
National Clinical Research
2025
Ministry of Education of the People's Republic of China
2021-2025
Chinese Academy of Sciences
2024
Jiangxi Science and Technology Normal University
2024
Xuan Wu Hospital of the Capital Medical University
2018-2024
Capital University
2020-2024
Peking University
2024
Union Hospital
2023
Huazhong University of Science and Technology
2023
China has a large population of older people, but not yet undertaken comprehensive study on the prevalence, risk factors, and management both dementia mild cognitive impairment (MCI).For this national cross-sectional study, 46 011 adults aged 60 years or were recruited between March 10, 2015, Dec 26, 2018, using multistage, stratified, cluster-sampling method, which considered geographical region, degree urbanisation, economic development status, sex age distribution. 96 sites randomly...
Abstract Lipid metabolism and oxidative stress are key mechanisms in Alzheimer's disease (AD). The link between plasma lipid metabolites AD patients is poorly understood. This study was to identify markers that distinguish amnestic mild cognitive impairment (aMCI) from NC, reveal potential links stress. We performed non‐targeted analysis of with AD, aMCI, NC using LC–MS/MS. malondialdehyde (MDA), glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD) levels were assessed. found...
Abstract Introduction The genetic risk effects of apolipoprotein E ( APOE ) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (SAD), and normal controls (NC) remain unclear in the Chinese population. Methods In total, 15 119 subjects, including 311 FAD patients PSEN1, PSEN2, APP, TREM2 , SORL1 pathogenic mutations (FAD [unknown]); 126 PSENs / APP [ PSENs/APP ]); 7234 SAD patients; 7448 NC were enrolled. ε4 analyzed across groups. Results prevalence genotype...
Alzheimer's disease (AD) is an aging-related neurodegenerative disease. We aimed to investigate the metabolic mechanisms of aging and AD identify potential biomarkers for early screening in a natural population. To analyze plasma metabolites related aging, we conducted untargeted metabolomics analysis using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry two-stage cross-sectional study. Spearman's correlation random forest were applied model...
Abstract INTRODUCTION It is challenging to predict which patients who meet criteria for subcortical ischemic vascular disease (SIVD) will ultimately progress cognitive impairment (SVCI). METHODS We collected clinical information, neuropsychological assessments, T1 imaging, diffusion tensor and resting‐state functional magnetic resonance imaging from 83 with SVCI 53 age‐matched SIVD without impairment. built an unsupervised machine learning model isolate SVCI. The was validated using...
Abstract Background Mutations in the mitochondrial alanyl‐transfer (t) RNA synthetase 2 ( AARS , OMIM :612035) have been linked to leukoencephalopathy recently. Till now, there 19 cases reported so far. However, clinical and genetic characteristics of this disease are not fully understood. We an adult‐onset male patient related novel gene mutations reviewed all previous regarding features leukoencephalopathy. Methods The spectrum symptoms analysis presented were identified investigated....
Abstract Background Although structural and functional changes of the striatum hippocampus are present in familial Alzheimer’s disease, little is known about effects specific gene mutation or disease progression on their related neural circuits. This study was to evaluate pathogenic striatum- hippocampus-related circuits, including frontostriatal hippocampus-posterior cingulate cortex (PCC) pathways. Methods A total 102 healthy non-carriers, 40 presymptomatic carriers (PMC), 30 symptomatic...
Breast cancer develops as a result of multiple gene mutations in combination with environmental risk factors. Causative variants genes such BRCA1 and/or BRCA2 have been shown to account for hereditary nature certain breast cancers. However,other genes, ATM, PALB2, BRIP1, CHEK, BARD1, while lower frequency, may also increase risk. There are few studies examining the role these causative variants. Our study aimed examine clinical and genetic characterization Chinese population. We tested panel...
Vanishing white matter disease (VWMD) is one of the most prevalent inherited leukoencephalopathies, which generally presents in childhood as a progressive disorder while less beginning adulthood. The present report describes clinical, neuroimaging, and genetic findings female patient with adult-onset VWMD. In addition, to provide clearer delineation clinical characteristics VWMD patients, 32 genetically confirmed EIF2B-mutated cases are summarized. described here suffered from long-term...
Cognitive health is a major determinant of human survival and quality life. As an increasing proportion the global population reaches old age (defined as 60 years older), dementia has become public social care priority.[1] China contains about 15.07 million people with dementia, accounting for 25% world's total population.[2] Due to relatively high individuals reaching age, expected have sharpest increase in cases any country over next few decades, causing ever-greater economic impacts. The...
Abstract Background It is challenging to predict which patients who meet criteria for subcor‐ tical ischemic vascular disease (SIVD) will ultimately progress subcortical cognitive impairment (SVCI). Method We collected clinical information, neuropsychological assessments, T1 imag‐ ing, diffusion tensor imaging, and resting‐state functional magnetic resonance imaging from 83 with SVCI 53 age‐matched SIVD without cogni‐ tive impairment. built an unsupervised machine learning model isolate...
To investigate the immune regulation mechanism of herb-partitioned moxibustion in rats with Crohn's disease (CD) focusing on autophagy.Rats were randomly divided into normal (N) group, CD model (M) (MM) (NM) mesalazine (western medicine, Med ) and saline (NS) 10 each group. The prepared by trinitrobenzene sulphonic expect for N group NM After established, MM groups treated at Tianshu (ST25) Qihai (CV6) acupoints once daily 7 days, NS respectively enteric coated tablet days. intervention,...