A5088631402- Acupuncture Treatment Research Studies
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Menstrual Health and Disorders
- Myofascial pain diagnosis and treatment
- Autoimmune and Inflammatory Disorders Research
- Pharmacological Effects of Natural Compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- interferon and immune responses
- Vitamin D Research Studies
- History of Medicine Studies
- Immune cells in cancer
- Extracellular vesicles in disease
- Healthcare and Venom Research
- Gut microbiota and health
- Calcium signaling and nucleotide metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal motility and disorders
- Music Therapy and Health
- Immune Response and Inflammation
- Psychosomatic Disorders and Their Treatments
- Ginger and Zingiberaceae research
Shanghai Research Center for Acupuncture and Meridians
2019-2023
Yueyang Hospital
2021-2023
Shanghai University of Traditional Chinese Medicine
2019-2023
Background Crohn’s disease (CD) has an increasing incidence and prevalence worldwide. It is currently believed that both the onset progression of are closely related to immune system imbalance infiltration cells. The aim this study was investigate molecular mechanisms associated with CD its fibrosis through bioinformatics analysis. Methods Three datasets from Gene Expression Omnibus data base (GEO) were downloaded for analysis validation. Single sample gene enrichment (ssGSEA) used evaluate...
Ulcerative colitis (UC), also known as chronic nonspecific UC, is an inflammatory bowel disease characterized by diffuse colonic mucosal inflammation. The incidence and prevalence of UC have risen markedly, the seriously affects quality life patients, poses a great burden on world health care infrastructure economy.We present 60-year-old man who had ulcerative for more than 10 years, with recurrent abdominal pain, bloody diarrhea mucopurulent stool. treatments sulfasalazine, mesalazine,...
Background . Electroacupuncture (EA) has been confirmed effectiveness in the treatment of irritable bowel syndrome (IBS), and P2X 3 receptors peripheral central neurons participate acupuncture-mediated relief visceral pain IBS. Objective To reveal neurobiological mechanism that receptor colonic primary sensory dorsal root ganglia lumbosacral segment is involved alleviation hypersensitivity by EA an IBS rat model. Methods The chronic model was established according to method Al-Chaer et al....
Ulcerative colitis (UC) is a chronic, nonspecific intestinal inflammatory disease. Acupuncture and moxibustion proved effective in treating UC, but the mechanism has not been clarified. Proteomic technology revealed variety of biological markers related to immunity inflammation which provide new insights directions for study acupuncture treatment UC.To investigate electroacupuncture (EA) herb-partitioned (HM) on UC rats by using proteomics technology.Male Sprague-Dawley were randomly divided...
To investigate the immune regulation mechanism of herb-partitioned moxibustion in rats with Crohn's disease (CD) focusing on autophagy.Rats were randomly divided into normal (N) group, CD model (M) (MM) (NM) mesalazine (western medicine, Med ) and saline (NS) 10 each group. The prepared by trinitrobenzene sulphonic expect for N group NM After established, MM groups treated at Tianshu (ST25) Qihai (CV6) acupoints once daily 7 days, NS respectively enteric coated tablet days. intervention,...
The clinical efficacy of acupuncture-moxibustion (AM) mainly depends on acupoints, but the relationship between acupoints and AM remains unclear. Improving clarifying mechanisms is critical. We found that specificity sensitivity skill operation, reasonable amount stimulation can significantly improve AM. In addition, some studies have shown Neural-Endocrine-Immune network metabolites are involved in this process, therapeutic mechanism acupoints. Therefore, how to effectively use one key...
Intestinal fibrosis is one of the severe and common complications Crohn's disease (CD), but etiology pathogenesis remain uncertain. The study intended to examine whether effect herb-partitioned moxibustion on rats with CD-associated intestinal associated RhoA/ROCK1/MLC pathway.All experimental were randomly allocated into normal control group (NC), model (MC), (HPM). was established in CD by repeated rectal administrations 2,4,6-trinitrobenzenesulfonic acid (TNBS). Herb-partitioned applied...
BACKGROUND Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recycling of related cellular components. Recent studies have shown autophagy plays important role the pathogenesis Crohn's disease (CD). Herbal cake-partitioned moxibustion (HM) has been historically practiced to treat CD. However, mechanism by which HM regulates colonic CD remains unclear. AIM To observe whether can alleviate regulating elucidate...
Abstract Objective To observe the clinical efficacy of herbal cake-partitioned moxibustion for ulcerative colitis (UC) and elucidate its mechanism by targeting vitamin D receptor (VDR) signaling pathway. Methods A total 63 patients with UC were randomly divided into an observation group (30 cases, treated moxibustion) a control (33 sham moxibustion). Moxibustion treatment was performed at Qihai (CV6) bilateral Tianshu (ST25) Shangjuxu (ST37), 3 times per week 12 weeks. The effective rate,...
Acupuncture and moxibustion have definite clinical effects on treating ulcerative colitis (UC), but their mechanism is still unclear. To investigate the molecular mechanisms, we applied herb-partitioned or electroacupuncture at Tianshu (ST25) points UC rats used RNA sequencing to identify consequences. Male Sprague Dawley (SD) were divided into 6 groups randomly: normal control (NC) group, + (NCHM) (NCEA) model (UC) (UCHM) (UCEA) group. Compared HE staining in UCHM group UCEA indicated that...
To investigate the mechanism of action herb-partitioned moxibustion on CD from perspective autophagy and immunity.The expression microtubule-associated protein LC3II SQSTM1/p62 in colon tissues was detected by immunohistochemistry. Western blot used to detect autophagic immune-related proteins colon, such as LC3II, SQSTM1/p62, Beclin1, ATG16L1, NOD2, IRGM, IL-1β, IL-17, TNF-β. mRNA levels immune factors, TNF-β, signaling molecules, PI3KC, AKT1, LKB1, mTOR, were RT-qPCR.Herb-partitioned...
Abstract Objective To explore the mechanism of herb-partitioned moxibustion in relieving rat intestinal inflammation by focusing on neutrophil extracellular traps (NETs) Crohn disease (CD) development. Methods Rats were randomly divided into a normal group, model and mesalazine group. The CD was prepared with 2,4,6-trinitrobenzene sulfonic acid except for rats group did not receive any treatment but had same fixation as other groups. received at Qihai (CV6) bilateral Tianshu (ST25)....
Abstract Objective To observe the anti-inflammatory effect, as well effect on expression of microtubule-associated protein light chain 3B (LC3B) and Beclin-1 herbal cake-partitioned moxibustion in rats with experimental autoimmune thyroiditis (EAT). Methods Female Sprague-Dawley were randomly divided into a normal group modeling group. The EAT rat model was prepared by combination antigen immunization plus iodine agent induction. After prepared, equally In group, alternately applied to two...