A5100387405- Chronic Myeloid Leukemia Treatments
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Sedative Agents
- Mitochondrial Function and Pathology
- Nuts composition and effects
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Endometriosis Research and Treatment
- Biochemical Analysis and Sensing Techniques
- PI3K/AKT/mTOR signaling in cancer
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Gastroesophageal reflux and treatments
- Pancreatitis Pathology and Treatment
- Nausea and vomiting management
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2025
University of Shanghai for Science and Technology
2022-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Xuzhou Medical College
2016-2024
Jiangsu Province Hospital
2016-2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Nanjing Medical University
2016-2024
Dalian Medical University
2021-2024
The roles and mechanisms of long noncoding RNAs (lncRNAs) in T helper 2 (Th2) differentiation from allergic asthma are poorly understood. We aimed to explore a novel lncRNA, LincR-protein phosphatase regulatory subunit B' gamma (PPP2R5C), Th2 mouse model asthma.
Oxidative stress plays critical roles in the development of diabetic cardiovascular complications, including myocardial hypertrophy. The β isoform PKC (protein kinase C) is preferentially overexpressed myocardium subjects accompanied with increased activation pro-oxidant enzyme NADPH oxidase, which may exacerbate oxidative stress. We hypothesized that PKCβ a major upstream mediator diabetes and inhibition can attenuate hypertrophy dysfunction. Control or streptozotocin-induced rats were...
The inhibition of demyelination and the promotion remyelination are both considerable challenges in therapeutic process for many central nervous system (CNS) diseases. Increasing evidence has demonstrated that neuroglial activation neuroinflammation responsible myelin sheath damage during demyelinating disorders. It been revealed nonselective cation channel transient receptor potential vanilloid 4 (TRPV4) profoundly affects a variety physiological processes, including inflammation. However,...
Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma. This study aimed to develop verify quick assay measurement givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as internal standard (IS), establishing basic pharmacokinetic profile its pre-clinical application metabolic stability in vitro. Sample preparation was performed via protein precipitation...
Nance–Horan syndrome (NHS) is a rare X-linked dominant disorder caused by pathogenic variants in the NHS gene on chromosome Xp22.2-Xp22.13. Clinical manifestations consist of congenital cataracts, along with dysmorphic facial features and dental anomalies and, certain instances, intellectual disability. This study aimed to identify genetic cause responsible for Chinese family four individuals primarily presenting cataracts. Genomic DNA was collected from six members, including affected...
Proline and its synthesis enzyme pyrroline-5-carboxylate reductase 1 (PYCR1) are implicated in epithelial-mesenchymal transition (EMT), yet how proline PYCR1 function allergic asthmatic airway remodeling via EMT has not been addressed. In the present study, increased levels of plasma were observed patients. Similarly, lung tissues higher a murine asthma model induced by house dust mites (HDMs). Pycr1 knockout (KO) decreased tissues, with reduced EMT. Mechanistically, loss restrained...
The purpose of this study was to investigate the relationship between glucose lymphocyte ratio (GLR) and outcome acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients admitted intensive care unit (ICU). This included 3573 from eICU Collaborative Research Database (eICU-CRD) 926 AECOPD ICU Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. optimal cutoff value GLR 5.6. Kaplan-Meier analysis demonstrated that in lower (< 5.6) group showed a better overall...
We investigated possible biomarkers for endometriosis (EM) using the ClinProt technique and proteomics methods.We enrolled 50 patients with EM, 34 benign ovarian neoplasms 40 healthy volunteers in this study. Serum proteomic spectra were generated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MS) combined weak cationic exchange (WCX) magnetic beads. Possible analyzed a random repeat pattern model-validation method that we designed, ClinProtools software,...
Previous studies mainly focused on the relationship between size of prolapse and injury to supporting tissues, but strain stress distributions tissues as well high-risk areas are still unknown. To further investigate effect organs interactions organs, this study high intra-abdominal pressure compliance pelvic floor support system in a normal woman without organ (POP), using finite element model whole system. A healthy female volunteer (55 years old) was scanned magnetic resonance imaging...
Background: Tirabrutinib is an orally effective, approved, and highly selective second-generation Bruton's tyrosine kinase (BTK) inhibitor for the treatment of recurrent or refractory primary central nervous system lymphoma (PCNSL). Objective: This study aimed to develop ultra-high performance liquid chromatography- tandem mass spectrometry (UPLC-MS/MS) method determination tirabrutinib concentration in rat plasma, where zanubrutinib was used as internal standard (IS). also applied whether...
Intestinal dysbiosis and disrupted bile acid (BA) homeostasis are associated with obesity, but the precise mechanisms remain insufficiently explored. Hepatic protein phosphatase 1 regulatory subunit 3G (PPP1R3G) plays a pivotal role in regulating glycolipid metabolism; nevertheless, its obesity-combatting potency remains unclear. In this study, substantial reduction was observed serum PPP1R3G levels high-body mass index high-fat diet (HFD)-exposed mice, establishing positive correlation...
Context Almonertinib is primarily metabolized by CYP3A4, so it could interact with a variety of drugs leading to the changes systemic exposure.
This study aimed to explore the characteristics of bone biochemical indices, including mineral density (BMD), metabolic markers in elderly women with osteoporotic intertrochanteric fracture and their relevance secondary fracture.The standard for follow-up from 58 was established analyse BMD injured hip, healthy vertebra at 1 week 12 months after fracture. The serum levels total procollagen type N-terminal propeptide (tPINP) age-related I cross linked C-telopeptide (β-CTX) were recorded...