A5100406121- Mitochondrial Function and Pathology
- Heavy metals in environment
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Mercury impact and mitigation studies
- Genetic Mapping and Diversity in Plants and Animals
- Adipose Tissue and Metabolism
- Photosynthetic Processes and Mechanisms
- Coal and Its By-products
- Autophagy in Disease and Therapy
- Soil Carbon and Nitrogen Dynamics
- Arsenic contamination and mitigation
- Mechanical and Optical Resonators
- Climate variability and models
- Microbial Community Ecology and Physiology
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Meteorological Phenomena and Simulations
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Toxic Organic Pollutants Impact
- Cryospheric studies and observations
- Muscle Physiology and Disorders
- Nanomaterials for catalytic reactions
- Pesticide and Herbicide Environmental Studies
Institute of Geochemistry
2018-2025
Chinese Academy of Sciences
2014-2025
University of Chinese Academy of Sciences
2018-2025
Soochow University
2024-2025
Institute of Genetics and Developmental Biology
2020-2025
East China University of Science and Technology
2025
Shanghai University of Medicine and Health Sciences
2025
Chinese University of Hong Kong
2022-2024
Inner Mongolia Agricultural University
2023-2024
Henan University
2024
Mild mitochondrial stress experienced early in life can have beneficial effects on the span of organisms through epigenetic regulations. Here, we report that acetyl-coenzyme A (CoA) represents a critical signal to regulate aging chromatin remodeling and histone deacetylase complex (NuRD) Caenorhabditis elegans. Upon stress, impaired tricarboxylic acid cycle results decreased level citrate, which accounts for reduced production acetyl-CoA consequently induces nuclear accumulation NuRD...
Neuronal mitochondrial function is critical for orchestrating inter-tissue communication essential overall fitness. Despite its significance, the molecular mechanism underlying impact of prolonged stresses on neuronal activity and how they orchestrate metabolism aging remains elusive. Here, we identified evolutionarily conserved transmembrane protein XBX-6/TMBIM-2 as a key mediator in neuronal-to-intestinal unfolded response (UPRmt). Our investigations reveal that intrinsic stress triggers...
Abstract The Tibetan Plateau (TP) is known as one of the sentinels global climate change. Substantial winter warming over TP will likely lead, directly or indirectly, to a series geological disasters such snow and glacial avalanches. Hence, for better adaptation change, it vital project future change in temperature TP. However, current state-of-the-art models involved sixth phase Coupled Model Intercomparison Project (CMIP6) still produce strong cold biases most parts their historical...
Calcination plays a vital role during material preparation. However, the calcination conditions have often been determined empirically or based on trial and error. Herein we present cooperative characterization approach to optimize by gas-cell in situ TEM collaboration with microcantilever-based thermogravimetric analysis (cantilever-TGA) techniques. The morphological evolution of precursors under atmospheric is observed TEM, right temperature provided cantilever-TGA. proposed successfully...
To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs approximately spherical shape with good stability. IVM was encapsulated in amorphous form within and displayed prolonged release from without burst due to high encapsulation efficiency (EE). cumulative permeation across excised rat skin significantly increased compared...
ABSTRACT Hypoxic preconditioning (HPC) alleviates the selective and delayed neuronal death in hippocampal CA1 region induced by transient global cerebral ischemia (tGCI). This type of cell may include different programmed mechanisms, namely, apoptosis necroptosis. Although apoptotic signaling is well defined, mechanisms that underlie necroptosis are yet to be fully elucidated. In this study, we investigated whether HPC protects neurons from ischemia‐induced We observed tGCI up‐regulated...
Acute myeloid leukemia (AML) is an aggressive haematological malignancy characterized by highly proliferative accumulation of immature and dysfunctional cells. Quercetin (Qu), one kind flavonoid, exhibits anti-cancer property in multiple types solid tumor, but its effect on acute less studied, the underlying mechanisms still largely unknown. This study aimed to explore specific target potential mechanism quercetin-induced cell death AML. First, we found that quercetin induces form apoptosis,...
Thermogravimetric analysis (TGA) is a widely applied classic method for material characterization. However, the existing TGA has reached its technical ceiling in regard to sensitivity, efficiency, application scope, and extensibility. With temperature-programming picogram (10–12 g) mass resoluble measurement function, an integrated resonant microcantilever proposed developed into micro-electromechanical system-based (MEMS TGA) technology satisfy significantly higher requirements. only...
Mitochondria constantly fuse and divide for mitochondrial inheritance functions. Here, we identified a distinct type of naturally occurring fission, tail-autotomy wherein tail-like thin tubule protrudes from the body disconnects, resembling autotomy. Next, utilizing an optogenetic mitochondria-specific mechanostimulator, revealed that mechanical tensile force drives fission. This force-induced fission involves DRP1/MFF endoplasmic reticulum wrapping. It redistributes DNA, producing fragments...
Coactivator-associated arginine methyltransferase 1 (CARM1), an important member of type I protein methyltransferases (PRMTs), has emerged as a promising therapeutic target for various cancer types. In our previous study, we have identified series PRMT inhibitors, among which ZL-28-6 (
Abstract Flexible Zn‐ion batteries (ZIBs) have been regarded as a promising energy storage solution for flexible electronics. However, the challenges of dendrite growth due to uneven current density distribution and limited anode flexibility impeded their practical application. Herein, 3D zinc with dual gradient in porosity conductivity is presented. This dual‐gradient nanofibrous exhibits exceptional durability, showing less than 10% change resistance after 15 000 bending cycles. The...
Antimony (Sb) is a widespread contaminant that poses potential carcinogenic risks worldwide. Many countries are grappling with significant historical Sb-containing waste, leading to soil contamination, which of international concern. The lack clarity on Sb sources and migration mechanisms in limits the effective prevention control pollution. This study utilized stable isotope techniques analyze profiles from two pollution scenarios, aims quantifying sources, understanding processes,...
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The difficulty in early diagnosis, combined with tendency for tumor invasion and metastasis, creates significant challenges current therapeutic approaches. Additionally, pharmaceutical agents currently used to treat NSCLC often come severe side effects can lead drug resistance. As a result, there an urgent need develop new fewer that effectively overcome resistance mechanisms. Flavonoids, prominent...