A5100687219- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Biochemical and Molecular Research
- Advanced biosensing and bioanalysis techniques
- Gut microbiota and health
- Macrophage Migration Inhibitory Factor
- Medicinal Plant Pharmacodynamics Research
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Biopolymer Synthesis and Applications
- Lipid metabolism and disorders
- Nanoparticle-Based Drug Delivery
- Acute Myeloid Leukemia Research
- Cancer Mechanisms and Therapy
- Retinal Diseases and Treatments
- Kruppel-like factors research
- Nuclear Receptors and Signaling
- Angiogenesis and VEGF in Cancer
- Spectroscopy Techniques in Biomedical and Chemical Research
- Antioxidant Activity and Oxidative Stress
- Protein Kinase Regulation and GTPase Signaling
Shanghai Children's Medical Center
2018-2025
Shanghai Jiao Tong University
2018-2025
Shihezi University
2024
Sun Yat-sen University
2015-2024
Fujian Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Xiangya Hospital Central South University
2016-2021
Central South University
2014-2021
Peking University
2021
Soochow University
2021
Growing evidence links microRNA to the process of peripheral vascular disease. Recently, we have found that microRNA-1298(miR-1298) is one most significantly down-regulated microRNAs in human arteries with arteriosclerosis obliterans (ASO) lower extremities. However, little known regarding its role ASO. The present study aimed investigate expression, regulatory mechanisms, and functions miR-1298 ASO.Using quantitative reverse-transcription PCR situ hybridization assays, was observed...
Acute myeloid leukemia (AML) is an aggressive haematological malignancy characterized by highly proliferative accumulation of immature and dysfunctional cells. Quercetin (Qu), one kind flavonoid, exhibits anti-cancer property in multiple types solid tumor, but its effect on acute less studied, the underlying mechanisms still largely unknown. This study aimed to explore specific target potential mechanism quercetin-induced cell death AML. First, we found that quercetin induces form apoptosis,...
Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein considered to play an important role in tumorigenesis. However, the correlation between ANXA1 expression tumor clinicopathological features patients with breast cancer remains unclear. This study investigated prognostic value of as marker. Tissue microarray blocks, containing 20 cases non-tumor tissue, benign lesion 135 (107 lymph node metastasis), were constructed. Expression these specimens was analyzed using...
Abstract De novo purine biosynthesis (DNPS) was previously shown to be aberrantly activated in many cancers. However, the activity of DNPS pathway and its underlying regulatory mechanism hepatoblastoma (HB) remain poorly understood. Herein, we discovered that expression PPAT, rate-limiting enzyme DNPS, markedly upregulated HB, leading an augmented flux via thereby promoting both HB cell proliferation migration. Furthermore, found mutant β-catenin, a dominant driver transcriptionally PPAT...
Lung cancer is a lethal that threatens human health. Several studies have demonstrated the role of long non-coding RNAs (lncRNAs) in lung cancer. SOX21-AS1 newly discovered oncogenic lncRNA, but its molecular mechanism not known. Here, levels SOX21-AS1, miR-24-3p, and PIM2 were examined normal tissues. The relationships between miR-24-3p or predicted using bioinformatics tools confirmed luciferase reporter assays. Colony formation, MTT, flow cytometry, transwell assays conducted to analyze...
Marital status is an independent prognostic factor for survival in many types of cancers, but its impact on patients with prostate cancer (PCa) has not been established. The aim this study was to explore the factors PCa and investigate effect marital outcomes different stratified by PCa. Using surveillance, epidemiology, end results (SEER) database, we collected data 584,655 diagnosed between 1975 2019. classified as married, divorced, widowed, single. We used Kaplan-Meier analysis single...
Polyethylene glycolated (PEGylated)curcumin-grafted-chitosan (PCC) conjugates were synthesized with three PEG/chitosan feed molar ratios (1/5, 1/7.5, and 1/10), namely PCC1, PCC2 PCC3. Chemical structures of these characterized by Fourier transform infrared (FTIR) proton nuclear magnetic resonance (¹H NMR). The degrees substitution (DS) PEG 0.75%, 0.45% 0.33%, respectively, for PCC3by ¹H NMR analysis. Self-assembled PCC nanoparticles (NPs) spherical as observed in transmission electron...
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in real world. We conducted a population-based study of all APL Zhejiang Province, China, with total population 82 million people, assess generalization all-trans retinoic acid (ATRA) arsenic as front-line treatment. The outcomes were also analyzed. Between January 2015 December 2019, 1,233 eligible included final analysis....
The gut microbiota of mammals is a complex ecosystem, which essential for maintaining homeostasis and the host's health. high throughput sequencing allowed us to gain deeper insight into bacterial structure diversity. In order improve health status endangered golden takins, we first characterized fecal healthy takins using 16S rRNA genes V3–V4 hypervariable regions. Our results showed that, Firstly, community comprised 21 phyla, 40 classes, 62 orders, 96 families, 216 genera. Firmicutes...
The aim of this study was to apply Raman spectroscopy in the high wavenumber (HW) region (2800 3000 cm−1) for ex vivo detection gastric cancer and compare its diagnostic potential with that fingerprint (FP) (800 1800 cm−1). spectra were collected FP HW regions differentiate between normal mucosa (n=38) (n=37). distinctive spectral differences tissues are observed at 853, 879, 1157, 1319, 1338, 1448, 2932 cm−1 primarily related proteins, lipids, nucleic acids, collagen, carotenoids tissue. In...
OBJECTIVES: The goal of our study was to assess the prognostic impact necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy hepatocellular carcinoma (HCC) patients. METHODS: In this study, expression its polymorphism(rs2272990) were examined plasma 44 HCC All these patients undergoing partial hepatectomy. values for tumor development survival, further determined. RESULTS: Plasma expressions significantly increased patients,...
Abstract Relapse‐specific mutations in phosphoribosyl pyrophosphate synthetase 1 ( PRPS ), a rate‐limiting purine biosynthesis enzyme, confer significant drug resistances to combination chemotherapy acute lymphoblastic leukemia ALL ). It is of particular interest identify drugs overcome these resistances. In this study, we found that mutant cells specifically showed more chemosensitivity 5‐Fluorouracil (5‐ FU ) than control cells, attributed increased apoptosis by 5‐ . Mechanistically,...
Peripheral artery disease (PAD) is an ischemic with a rising incidence worldwide. The lncRNA H19 (H19) enriched in endothelial progenitor cells (EPCs), and transplantation of pyroptosis-resistant H19-overexpressed EPCs (oe-H19-EPCs) may promote vasculogenesis blood flow recovery PAD, especially critical limb ischemia (CLI).
To investigate the differently expressed genes in human colorectal adenocarcinoma.The integrated approach for gene expression profiling that couples suppression subtractive hybridization, high-throughput cDNA array, sequencing, bioinformatics analysis, and reverse transcriptase real-time quantitative polymerase chain reaction (PCR) was carried out. A set of clones including 1260 SSH inserts amplified by PCR arrayed using robotic printing. The arrays were hybridized with fluorescent-labeled...
Elucidating the dysregulated metabolic pathways in cancer cells and their relevance to cisplatin resistance could yield new insights into therapy. We previously reported that eight metabolites involved tricarboxylic acid (TCA) cycle glutamine metabolism were associated with platinum-based chemotherapy efficacy human lung cancer. Here, we investigated differences upon treatment vitro vivo. A simple partially validated standard addition method was applied for quantification of five TCA using...
A sensitive, reliable and specific LC-MS-MS method was developed validated for the identification quantitation of all-trans retinoic acid (ATRA) in human plasma. Acitretin used as internal standard (IS). After liquid-liquid extraction 500 μL plasma with methyl tert-butyl ether (MTBE), ATRA IS were chromatographed on a HyPURITY C18 column (150 mm × 2.1 mm, 5 μm) temperature set at 40 °C. The mobile phase consisted 40% (MTBE–methanol–acetic acid, 50:50:0.5, v/v) 60% B (water–methanol–acetic...
More and more studies have shown that long non-coding RNA (LncRNA) as a competing endogenous (ceRNA) plays an important role in lung cancer. Therefore, we analyzed the expression profiles of 82 cancer patients which were all from Gene Expression Omnibus (GEO).Firstly, used BLASTN (evalue = 1e-10) to annotate gene sets, performed in-group correction batched normalization three data sets with R. Secondly, limma sva packages compare tumor tissues normal tissues. Then through WGCNA, obtained 4...
To investigate the immunogenicity of Homo sapiens putative translation initiation factor (Sui1) in hepatocellular carcinoma (HCC), enzyme-linked immunosorbent assay (ELISA) and Western blot were utilized to assess autoantibody responses Sui1 sera from HCC patients healthy individuals. Indirect immunofluorescence (IIF) with cancer cells immunohistochemistry (IHC) study tissue array slides performed examine expression profile tissues. The data confirmed that frequency was 15.5 % (16/103),...