A5030741188- COVID-19 Clinical Research Studies
- Urinary Bladder and Prostate Research
- Cell death mechanisms and regulation
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Liver Disease and Transplantation
- Ginseng Biological Effects and Applications
- Maternal and fetal healthcare
- Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Asthma and respiratory diseases
- Mitochondrial Function and Pathology
- COVID-19 diagnosis using AI
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- SARS-CoV-2 and COVID-19 Research
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Organ Transplantation Techniques and Outcomes
- Respiratory and Cough-Related Research
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
Hangzhou Red Cross Hospital
2014-2025
First Affiliated Hospital Zhejiang University
2011-2024
Zhejiang University
2011-2023
Xian Yang Central Hospital
2020-2023
Nanjing University of Chinese Medicine
2023
Suzhou Traditional Chinese Medicine Hospital
2023
Nanchang University
2023
Second Affiliated Hospital of Nanchang University
2023
Nanjing Drum Tower Hospital
2013-2022
Nanjing Medical University
2022
Rationale: Carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections are a severe complication resulting from granulocyte deficiency following chemotherapy for hematologic malignancies and have high mortality rate. However, reports of disseminated organ secondary to rare. Patient concerns diagnoses: We report 2 cases patients with acute lymphoblastic leukemia who both developed CRKP during the stage chemotherapy, 1 case bacterial liver abscess septic arthritis. Interventions...
The objective of this study is to provide comprehensive and up-to-date estimates on the disease burden BPH in 204 countries territories between 1990 2019. Data about incidence, year lived with disability (YLD), their age-standardized rates (ASRs) for 21 regions, 5 Socio-demographic Index (SDI) quintiles, territories, 12 age categories from 2019 were obtained Global Burden Disease study. Estimated annual percentage changes (EAPCs) ASRs associations SDI estimated. effects population growth,...
Objective: To study the prevalence of, and discuss factors contributing to, household second-hand smoke exposure in six counties China, providing scientific support for need to establish tobacco control measures these areas. Methods: A cross-sectional survey was performed. Investigators conducted face-to-face interviews using a standardised questionnaire collect information on demographics, passive smoking behaviours knowledge, attitudes towards control. The setting from three provinces:...
Rationale: Immune thrombocytopenia (ITP) is an autoimmune-mediated disorder caused by antibody-mediated platelet destruction and impaired production megakaryocytes. Treating refractory ITP remains a significant challenge. Patient Concerns Diagnoses: We report 2 patients with ITP. Interventions Outcomes: Two received low-dose decitabine combined recombinant human thrombopoietin or eltrombopag. Platelet counts in both increased to within the normal range. Lessons: Low-dose eltrombopag may...
Abstract The mortality of coronavirus disease 2019 (COVID-19) differs between countries and regions. This study aimed to clarify the clinical characteristics imported second-generation cases in Shaanxi. included 134 COVID-19 Shaanxi outside Wuhan. Clinical data were compared severe non-severe cases. We further profiled dynamic laboratory findings some patients. In total, 34.3% patients cases, 11.2% had complications. As 7 March 2020, 91.8% discharged one patient (0.7%) died. Age, lymphocyte...
Background Salvage liver transplantation (SLT) has been reported as being feasible for patients who develop recurrent hepatocellular carcinoma (HCC) after primary resection, but this finding remains controversial. We retrospectively studied the clinical characteristics of SLT recipients and conducted a comparison between (PLT) recipients. Methodology Principal Findings A retrospective study examined data from China Liver Transplant Registry (CLTR) 6,975 transplants performed January 1999 to...
Lactate dehydrogenase 5 (LDH-5) is one of the major isoenzymes catalyzing biochemical process pyruvate to lactate. The purpose this study was investigate expression serum LDH-5 and test whether enzyme regulated by tumor hypoxia represents a prognostic marker in patients with Non-Hodgkin's lymphoma (NHL). In study, levels were detected using agarose gel electrophoresis NHL (n = 266) non-NHL controls including benign lymphadenectasis 30) healthy cohorts 233). We also explored hypoxia-inducible...
A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are thought to contribute the development maintenance neuropathic pain. However, responsible for pain have not been completely delineated. It has demonstrated that neuropeptide galanin (Gal) is upregulated after injury in dorsal root ganglion (DRG) spinal horn (SDH) where it plays a predominantly antinociceptive role. In present study, sciatic nerve-pinch rat model was used determine effects exogenous Gal on...
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in real world. We conducted a population-based study of all APL Zhejiang Province, China, with total population 82 million people, assess generalization all-trans retinoic acid (ATRA) arsenic as front-line treatment. The outcomes were also analyzed. Between January 2015 December 2019, 1,233 eligible included final analysis....
Abstract Background The mortality of COVID-19 differs between countries and regions. By now, reports on are largely focused first-generation cases. This study aimed to clarify the clinical characteristics imported second-generation Methods retrospective, multicenter cohort included 134 confirmed cases from 9 cities outside Wuhan. Epidemiological, outcome data were extracted medical records compared severe non-severe We further profiled dynamic laboratory findings some patients. Results 34.3%...
Background and Aims The failure of therapeutic response to clopidogrel in platelet inhibition, which is called resistance (CR), more likely cause cardiovascular events. We aimed study the contribution promoter DNA methylation paraoxonase 1 ( PON1 ) risk poor response. Methods Through VerifyNow P2Y12 assay, patient’ functions were measured. Among 57 non‐CR 49 CR patients, levels four CpG dinucleotides on tested using bisulfite pyrosequencing technology. Besides, relative expression mRNA was...
Imatinib resistance has emerged as a significant clinical problem in chronic myeloid leukemia (CML) treatment. In this study, we investigated the effect and mechanism of combination treatment with imatinib cryptotanshinone (CPT) CML cells. Cotreatment CPT showed synergistic killing both sensitive resistant cell lines, well primary Furthermore, induced apoptosis significantly, indicated by increases apoptotic fraction activities proapoptotic proteins. Subsequent studies revealed that...
Objective: Coronary heart disease (CHD) is the most common cause of death worldwide.This study aimed to validate association rs964184 polymorphism with CHD risk and included 874 patients 776 controls.Methods: genotyping was performed using Tm-shift polymerase chain reaction.Results: A strong found (genotype: X 2 =14.365, p=0.001; allele: =14.191, p=1.6710 -4 ; power=0.965).Gender analysis revealed a significant only in males =12.387, p=0.002; =12.404, p=4.3210 OR=1.467, 95%...