A5072710015- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nutritional Studies and Diet
- Single-cell and spatial transcriptomics
- Health and Well-being Studies
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Esophageal Cancer Research and Treatment
- Retinoids in leukemia and cellular processes
- Acupuncture Treatment Research Studies
- Obesity, Physical Activity, Diet
- Cancer Risks and Factors
- Gastrointestinal Tumor Research and Treatment
- Cancer Treatment and Pharmacology
- Liver physiology and pathology
- Immune cells in cancer
- Health and Wellbeing Research
- Protein Hydrolysis and Bioactive Peptides
- Acute Myeloid Leukemia Research
- Paraquat toxicity studies and treatments
- Hemoglobinopathies and Related Disorders
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Inhalation and Respiratory Drug Delivery
- Gastric Cancer Management and Outcomes
National Cheng Kung University Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Lanzhou University
2023-2025
Academy of Medical Sciences
2025
Shenzhen University Health Science Center
2023
The First People's Hospital of Xiaoshan District, Hangzhou
2021
Enzo Life Sciences (United States)
2010
396 Background: Perioperative triplet chemotherapy improves the survival and surgical outcome of patients with locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma in addition to curative surgery. 5-fluorouracil (5-FU), docetaxel, oxaliplatin leukovorin (FLOT) has been suggested as treatment choice. S-1, an oral fluoropyrimidine chemotherapeutic, also shows compelling efficacy one backbone is exempt from a prolonged infusion time. However, comparison over tolerability...
Renal fibrosis, resulting from myofibroblast-mediated excessive extracellular matrix (ECM) deposition, lacks effective treatments. Novel peptide DR3penA developed by our group showed therapeutic potential for fibrotic diseases; however, its application was hindered poor stability and bioavailability. To address this unmet need, we implemented stepwise optimization of DR3penA. The conformationally restricted analogs designed via structural predictions enhanced both activity stability. Through...
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in real world. We conducted a population-based study of all APL Zhejiang Province, China, with total population 82 million people, assess generalization all-trans retinoic acid (ATRA) arsenic as front-line treatment. The outcomes were also analyzed. Between January 2015 December 2019, 1,233 eligible included final analysis....
Renal fibrosis is a complex pathological process that contributes to the development of chronic kidney disease due various risk factors. Conservative treatment curb progression without dialysis or renal transplantation widely applicable, but its effectiveness limited. Here, inhibitory effect novel peptide DR3penA (DHα-(4-pentenyl)-AlaNPQIR-NH2), which was developed by our group, on assessed in cells and mice with established triggered transforming growth factor-β1 (TGF-β1), unilateral...
Pulmonary fibrosis (PF), which is caused by continuous alveolar epithelial cell injury and abnormal repair, referred to as a difficult disease of the lung system World Health Organization due its rapid progression, poor prognosis, high mortality rate. However, there still lack ideal therapeutic strategies. The peptide DR8 (DHNNPQIR-NH2 ), derived from rapeseed, exerted antifibrotic activity in lung, liver, kidney our previous studies. By studying structure-activity relationship rational...
Interstitial lung diseases (ILDs) are a group of restrictive characterized by interstitial inflammation and pulmonary fibrosis. The incidence ILDs associated with exposure to multiple hazards such as inhaled particles, fibers, ingested soluble chemicals is increasing yearly, there no ideal drugs currently available. Our previous research showed that the novel low-toxicity peptide DH
According to the literature, cytokine levels observed in serum have a dependent relationship patient's age. Despite recognition of this important relationship, it has been largely overlooked as component cytokine-based assay modeling and development. In 466-subject breast cancer detection study, we examined impact that age-stratified analysis on serum-cytokine-based assay's performance. Patient samples were analyzed for 4-cytokines (i.e. Interleukin-8 Interleukin-12 p40/p70, hepatocyte...
Objective To investigate the relationship of emotional character, personality alexithymia disease concept, healthy seeking behaviors, family environment and dynamics with irritable bowel syndrome(IBS) patients. Methods 126 IBS patients 126 controls were evaluated by questionnaires Self-Rating Anxiety Scale (SAS), Depression scale (SDS), Family Environment (FES), Self-rating Systemic Dynamics (SSFD), Eysenck Personality Questionnaire (EPQ), Toronto Alexithymia (TAS), self-rating...