A5060794007- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Autophagy in Disease and Therapy
- Biochemical and Structural Characterization
- Chemical Synthesis and Analysis
- Plant-Microbe Interactions and Immunity
- Image Enhancement Techniques
- Advanced Image Fusion Techniques
- Advanced Image and Video Retrieval Techniques
- Advanced Neural Network Applications
- Calcium signaling and nucleotide metabolism
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Mapping and Diversity in Plants and Animals
- Sirtuins and Resveratrol in Medicine
- Burn Injury Management and Outcomes
- Gait Recognition and Analysis
- Advanced Vision and Imaging
- Human Pose and Action Recognition
- Image and Signal Denoising Methods
- Inhalation and Respiratory Drug Delivery
- Plant nutrient uptake and metabolism
- Video Surveillance and Tracking Methods
- Medical Image Segmentation Techniques
- Visual Attention and Saliency Detection
Nanjing Agricultural University
2024-2025
Dalian University of Technology
2020-2025
Lanzhou University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Shanghai University of Sport
2025
Academy of Medical Sciences
2025
Dalian University
2024
Northwest A&F University
2024
South China Agricultural University
2022
South China University of Technology
2022
Abstract BNIP3 is an atypical BH3-only member of the Bcl-2 family with pro-death, pro-autophagic, and cytoprotective functions, depending on type stress cellular context. Recently, we demonstrated that stimulates migration epidermal keratinocytes under hypoxia. In present study found autophagy expression were concomitantly elevated in migrating epidermis during wound healing a hypoxia-dependent manner. Inhibition through lysosome-specific chemicals (CQ BafA1) or Atg5-targeted...
Objective . The present study explored the association between insulin resistance (IR) and clinical characteristics of thyroid nodules in patients with type 2 diabetes mellitus (T2DM). Methods All were newly diagnosed T2DM. 201 nodule disease 308 without nodular disease. participants evaluated by relevant examination. Correlation analyses regression performed to examine relationships two groups. Results HOMA-IR values, serum FT4 (free thyroxine) levels, age higher group than control group....
This paper presents a detection method of insulator stings for aerial inspection based on feature-fusion. The local sub-images strings are firstly collected from videos and tagged to establish training dataset. fusion feature is then composed by the histogram oriented gradients (HOG) binary pattern (LBP) after principal component analysis (PCA) dimension reduction separately. A model developed SVM algorithm with feature. At phase, threshold segmentation morphological operation adopted...
Existing fine-grained image recognition methods are difficult to learn complete discriminative features from low-resolution (LR) data, because the original subtle inter-class distinctions become slimmer with reduction of resolution. Besides, existing LR and general only consider restoration extraction global features, ignoring unreliable local details can be detrimental final recognition. To address above problems, we propose a multi-tasking framework, feature mining enhancement network...
Abnormal lipid metabolism, renal accumulation and lipotoxicity are associated with the pathological features of glomerulopathy. However, mechanisms by which leads to development or progression this disease have not been fully elucidated. In work, we identified a role for rate-limiting enzyme in lipolysis, adipose triglyceride lipase (ATGL; also called patatin-like phospholipase domain-containing protein 2), metabolism kidney disease. ATGL-deficient (Atgl(-/-)) mice displayed albuminuria,...
Summary Phytophthora parasitica causes diseases on a broad range of host plants. It secretes numerous effectors to suppress plant immunity. However, only few virulence in P. have been characterized. Here, we highlight that PpE18, conserved RXLR effector , was factor and suppresses Nicotiana benthamiana immunity . Utilizing luciferase complementation, co‐immunoprecipitation, GST pull‐down assays, determined PpE18 targeted NbAPX3‐1, peroxisome membrane‐associated ascorbate peroxidase with...
ABSTRACT Erythropoietin (EPO) abuse in sports has been a major challenge doping analysis for decades. Although the Athlete Biological Passport (ABP) serves as an indirect method EPO detection, it requires continual improvement to increase its sensitivity and reliability. Biomarkers related iron metabolism erythropoiesis complementary parameters enhance ABP hematology module have potential improve ability detect indirectly. In this study, RNA was extracted from dried blood spot (DBS) samples...
Renal fibrosis, resulting from myofibroblast-mediated excessive extracellular matrix (ECM) deposition, lacks effective treatments. Novel peptide DR3penA developed by our group showed therapeutic potential for fibrotic diseases; however, its application was hindered poor stability and bioavailability. To address this unmet need, we implemented stepwise optimization of DR3penA. The conformationally restricted analogs designed via structural predictions enhanced both activity stability. Through...
<title>Abstract</title> Cytokinin signal transduction occurs through a "two-component system." Type-A and -C response regulators (RRs) are groups of proteins similar structures constituting significant components cytokinin transduction. In rice, 13 (Type-A) two (Type–C) <italic>RRs</italic> have been identified to date; however, their functions remain partially known. this study, we examined the expression patterns Type-C RRs in rice using RNA-Seq confirmed by constructing mutants 15 genes...
Induced autophagy is protective against myocardial hypoxia/ischemia (H/I) injury, but evidence regarding the extent of autophagic clearance under H/I and molecular mechanisms that influence flux has scarcely been presented. Here, we report CD38 knockout improved cardiac function in CD38-/- mice neonatal cardiomyocytes (CMs) conditions. Mechanistic studies demonstrated overexpression specifically downregulated expression Rab7 its adaptor protein pleckstrin homology domain-containing family...
Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) is an important soilborne fungal pathogen that causes the most devastating banana disease. Effectors secreted by microbes contribute to virulence on host plants in plant-microbe interactions. However, functions of Foc TR4 effectors remain largely unexplored. In this study, we characterized a novel cupin_1 domain-containing protein (FoCupin1) from TR4. Sequence analysis indicated homologous proteins FoCupin1 phytopathogenic fungi...
Pulmonary fibrosis (PF) is a pathological change caused by repeated injuries and repair dysfunction of the alveolar epithelium. Our previous study revealed that residues Asn3 Asn4 peptide DR8 (DHNNPQIR-NH2) could be modified to improve stability antifibrotic activity, unnatural hydrophobic amino acids α-(4-pentenyl)-Ala d-Ala were considered in this study. DR3penA (DHα-(4-pentenyl)-ANPQIR-NH2) was verified have longer half-life serum significantly inhibit oxidative damage,...
Abstract Leaf shape and angle are crucial components of plant architecture substantially influence photosynthetic efficiency crop productivity. In this study, we found that OsGRF1 (GROWTH-REGULATING FACTOR 1) OsGRF2 play unequally redundant roles in regulating leaf development. The osgrf1 mutant showed increased angle, mutations further enhanced effect, although the osgrf2 remained unchanged. Cell elongation on adaxial collar side caused an angle. rOsGRF1 rOsGRF2 materials, resistant to...
The development of antimicrobial compounds is now regarded as an urgent problem. Antimicrobial peptides (AMPs) have great potential to become novel drugs. Feleucin-K3 α-helical cationic AMP isolated from the skin secretion Asian bombinid toad species Bombina orientalis and has activity. In our previous studies, amino acid scanning was performed determine key site affecting its this study, we investigated synthesized a series analogues that either natural or unnatural hydrophobic substitution...
The prevalence of multidrug-resistant bacterial infections has led to dramatically increased morbidity and mortality. Antimicrobial peptides (AMPs) have great potential as new therapeutic agents reverse this dangerous trend. Herein, a series novel AMP Feleucin-K3 analogues modified with unnatural peptidomimetic sulfono-γ-AA building blocks were designed synthesized. structure–activity, structure–toxicity, structure–stability relationships investigated discover the optimal antimicrobial...
We aimed to evaluate the efficacy and safety of three dipeptidyl peptidase 4 (DPP-4) inhibitors (vildagliptin, sitagliptin, linagliptin) as add-on therapy in Chinese patients with type 2 diabetes mellitus (T2DM)inadequately controlled on dual combination insulin metformin or acarbose.A total 535 T2DM who failed achieve glycemic control a traditional oral hypoglycemic agent were randomized receive vildagliptin, linagliptin. Body mass index, glycosylated hemoglobin (HbA1c), fasting...
Background/Aims: Regional hypoxia promptly develops after trauma because of microvascular injury and increased oxygen consumption. This acute plays a positive role in early skin wound healing. One the mechanisms underlying beneficial effects on healing may be hypoxia-inducible factor-1 (HIF-1α) expression. HIF-1α affect wound-healing process through many aspects, including angiogenesis, metabolism, extra-cellular matrix synthesis remodelling. Epidermal stem cells (EpSCs) are important...
Abstract The migration of keratinocytes from wound margins plays a critical role in the re‐epithelialization skin wounds. Hypoxia occurs immediately after injury and acts as an early stimulus to initiate healing processes. Although our previous studies have revealed that hypoxia promotes keratinocyte migration, precise mechanisms involved remain unclear. Here, we found BNIP 3 expression was upregulated hypoxic keratinocytes, silencing suppressed hypoxia‐induced cell migration. Additionally,...
Oxygen tension is an important micro-environmental factor that affects epidermal development and function. After injury, high oxygen consumption vascular injury result in partial hypoxia. However, whether hypoxia benefits or hurts wound healing remains controversial. In this study, a tissue monitor was used to detect the spatial temporal distribution of burn wounds. vitro, we demonstrate promoted expression integrin β1 migration keratinocytes. Furthermore, hypoxia-induced slowed by Notch1...