A5065888879- Acute Myeloid Leukemia Research
- Supply Chain and Inventory Management
- Acute Lymphoblastic Leukemia research
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Quality and Supply Management
- Chronic Lymphocytic Leukemia Research
- Rough Sets and Fuzzy Logic
- Pneumonia and Respiratory Infections
- Multi-Criteria Decision Making
- Sustainable Supply Chain Management
- Corporate Finance and Governance
- Working Capital and Financial Performance
- Product Development and Customization
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Enzyme Catalysis and Immobilization
- Supply Chain Resilience and Risk Management
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Protein Degradation and Inhibitors
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2024
Wenzhou Medical University
2004-2024
Anhui Jianzhu University
2019-2024
Hefei University of Technology
2018-2024
Soochow University
2020-2022
Xiamen University
2019-2020
First Affiliated Hospital of Xiamen University
2020
Fujian University of Traditional Chinese Medicine
2019
Zunyi Medical University
2017
Qingdao University
2006-2016
Increased intracranial pressure (ICP) results in enlarged optic nerve sheath diameter (ONSD). In this study the authors aimed to assess association of ONSD and ICP severe traumatic brain injury (TBI) after decompressive craniotomy (DC).
Multi-attribute group decision making is widely used in the real world, and many scholars have done a lot of research on it. The public’s focus emergencies can provide an important reference for emergency handling social media big data environment. Due to complexity making, asymmetry user evaluation information easy cause loss information. It very mine valuable through online reviews. Then, generalized extended hybrid distance measure method between probabilistic linguistic term sets...
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in real world. We conducted a population-based study of all APL Zhejiang Province, China, with total population 82 million people, assess generalization all-trans retinoic acid (ATRA) arsenic as front-line treatment. The outcomes were also analyzed. Between January 2015 December 2019, 1,233 eligible included final analysis....
The genetic etiology of sporadic neuroblastoma remains largely obscure. RAN and RANBP2 genes encode Ras-related nuclear protein Ran-binding 2, respectively. These two proteins form Ran-RanBP2 complex that regulate various cellular activities including transport. Aberrant functions the are implicated in carcinogenesis. Given unknown role RAN/RANBP2 single nucleotide polymorphisms (SNPs) risk, we performed a multi-center case-control study Chinese children to assess association SNPs with risk....
Background:The aim of this study was to investigate the association polymorphism folylpolyglutamate synthetase (FPGS) with dynamic plasma concentration methotrexate (MTX) in pediatric patients acute lymphocytic leukemia (ALL), as well prognosis.Material/Methods: 57 ALL and 31 age sex-matched children (control) were included study.Polymerase chain reaction-restriction fragment length performed for analysis genotype FPGS rs1544105 high-performance liquid chromatography measurement MTX after...
To investigate the mechanism of survivin, p53 and Ki-67 on Hep-2 human laryngeal cancer endothelial cell proliferation invasion.Laryngeal squamous carcinoma paracancerous normal tissues were collected, total RNA was extracted from tissues, gene mRNA expression levels in adjacent detected by Real-time PCR. Human epithelial cells selected, survivin overexpressed, MTT. changes overexpressed Western blot. Changes invasive ability studied when as Transwell invasion assay.In relative 1.72 ± 0.9,...
To discuss the effect and mechanism of miR-34a on proliferation, apoptosis invasion laryngeal carcinoma cells.The squamous Hep2 cells were transiently transfected with mimics NC. The MTT, colony-forming assay, Hoechst staining AnnexinV-PI double flow cytometry employed to detect viability cells; Transwell assay defect migration western blot RT-PCR expression survivin Ki-67 mRNA in cells.Compared NC group, cell miR-34 group was significantly decreased (P < 0.01), rate increased abilities...
The aim of this study was to analyze the efficacy and underlying mechanism adipose-derived mesenchymal stem cell exosome (ADSC-exosomes)-mediated protection on methotrexate (MTX)-induced neuronal damage. We established a H2O2-induced oxidative stress model in vitro, as well an MTX-induced damage rat vivo. analyzed effects ADSC-exosomes Nrf2-ARE signaling pathway rats related mechanisms. morphological functional recovery hippocampal neurons by examined Nissl staining modified neurological...
A cascade biocatalysis system involving asymmetric hydroxylation and diastereoselective oxidation was developed giving the title compounds in good yields.
Glioblastoma (GBM) is a type of central nervous system malignancy. In our study, we determined the effect
The present study aimed to investigate the association between genetic polymorphism of cytochrome P450 family 3 subfamily A member 5 (CYP3A5) and activity CYP3A plasma concentrations daunorubicin (DNR) in patients with acute leukemia. total 36 children newly diagnosed lymphoblastic leukemia were enrolled study. Polymerase chain reaction (PCR)‑restriction fragment length PCR product sequencing used detect genotype CYP3A5*3. was then express mRNA expression CYP3A5. midazolam probe method...
Objective: This study evaluated the pharmacokinetics, safety, and bioequivalence (BE) of two formulations rasagiline tablets in healthy Chinese subjects under fasting fed conditions. Methods: An open, randomized, single-dose, double-cycle, two-sequence, self-crossover pharmacokinetic high-fat postprandial conditions was performed. A total 108 (36 group 72 group) were recruited. In each cycle both conditions, received a single oral dose 1 mg test or reference preparation (1 each). washout...
Abstract Background Early and rapid identification of Pseudomonas aeruginosa ( P. ) in patients with suspected ventilator-associated pneumonia (VAP) provides theoretical clinical advantages therapeutic optimization strategies. Methods The aeruginosa- multiple cross displacement amplification PA-MCDA) assay was conducted at an isothermal temperature during the stage, products were visually detected by color changes. entire process completed within 1 h. A total 77 strains, including species...
The predictive value of interleukin-35 (IL-35) on efficacy immunosuppressive therapy (IST) in aplastic anemia (AA) has not been well investigated. aim the study was to evaluate association between serum IL-35 level and response IST pediatric AA.A total 154 children with AA controls were included January 2012 December 2013. Blood bone marrow fluid specimens collected. Serum determined by enzyme-linked immunosorbent assay. Patients treated IST, evaluated during 180-day follow-up period after...
Abstract Wilms tumor is the most common pediatric malignancy in kidney. The miR34b/c a downstream target gene of transcription factor p53. important role TP53 mutations, methylation miR34b/c, and interaction between these two molecules tumorigenesis have been well documented. Due to biological connection p53 present study, we investigated association polymorphisms susceptibility through genotyping functional (miR34b/c rs4938723 T&gt;C rs1042522 C&gt;G) 183 cases 603 controls....
Fuzzy semantics have a wide range of applications in life, and especially when expressing people’s evaluation information, it is more specific. As people increasingly prefer to express their personal opinions through media platforms, the general public become an indispensable reference. However, information asymmetry can significant impact on rationality decision-making. Based above considerations, this paper extends bidirectional projection probabilistic linguistic term sets preserve...
A novel multi-attribute group decision making (MAGDM) method with multi-granular probabilistic linguistic power is proposed in this paper. Firstly, distance measures between two term sets are determined, such as generalized Hamming distance, Euclidean Hausdorff and hybrid approach. To compute the weights of attributes, we propose cross-entropy for sets; Secondly, under all determined above, a MAGDM proposed; Finally, four case studies provided to illustrate novelty, feasibility, validity...
The paper constructs a supply chain model which is composed of the generic module supplier and manufacturer when implementing mass customization in internet environment.Also, gives delay production cost optimization model, considering intelligent caused by adding modules.In end, determines optimal CODP location using numerical simulation.The simulation shows that, moves downstream after intelligence modules thus more need to be generalized for achieving intelligence, can also shorten...