A5101478150- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Protease and Inhibitor Mechanisms
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Child Development and Digital Technology
- Cancer Risks and Factors
- Health and Well-being Studies
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer Mechanisms and Therapy
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Impact of Technology on Adolescents
- RNA modifications and cancer
- Spinal Hematomas and Complications
- Bioactive Compounds and Antitumor Agents
- Opioid Use Disorder Treatment
- Quinazolinone synthesis and applications
- Virus-based gene therapy research
- Spinal Dysraphism and Malformations
- Sinusitis and nasal conditions
- Travel-related health issues
- Cardiovascular Health and Risk Factors
Jinan University
2023
Ping An (China)
2020-2022
Hubei Provincial Center for Disease Control and Prevention
2008-2021
Peking University
2012-2021
Peking University People's Hospital
2012-2021
Wuhan Center for Disease Control and Prevention
2012-2020
Meitan General Hospital
2019
Central Hospital of Zibo
2018-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Hebei University of Engineering
2016
To estimate influenza-associated mortality in urban China.Influenza-associated excess for the period 2003-2008 was estimated three cities temperate northern China and five subtropical south of country. The estimates were derived from models based on negative binomial regressions, vital statistics results weekly influenza virus surveillance.Annual mortality, all causes, 18.0 (range: 10.9-32.7) deaths per 100,000 population 11.3 7.3-17.8) southern cities. Excess respiratory circulatory disease...
Abstract Background China's socioeconomic and population structures have evolved markedly during the past few decades, consequently, monitoring prevalence of Parkinson's disease (PD) is crucial. Objective This study aimed to investigate PD within Chinese communities, particularly in older people. Methods A nationwide 24,117 participants, aged 60 years or older, was carried out 2015 using multistage clustered sampling. All participants were initially screened a nine‐item questionnaire, from...
Interspecies sensitivity to the same chemical can be several orders of magnitude different. Quantifying toxicologically internal levels and toxicokinetic (TK) parameters is critical in elucidating interspecies sensitivity. Herein, a two-compartmental TK model was constructed characterize uptake, distribution, elimination kinetics toward an insecticide, imidacloprid. Imidacloprid exhibited highest lethality insect Chironomus dilutus, followed by Lumbriculus variegatus, Hyalella azteca,...
It has previously been reported that dihydroartemisinin (DHA) is an effective novel anticancer compound in a number of types tumor cells. Previous studies have demonstrated the activity DHA gioma However, its underlining mechanism remains unclear. In present study, was examined glioma cell lines BT325 and C6. Western blot analysis also employed to determine signaling pathway changes. effectively inhibited growth induced apoptosis Moreover, western indicated DHA‑induced accompanied by...
Objective: This study aims to estimate the prevalence of dementia and Alzheimer's disease (AD) associated risk factors among general Chinese population. Methods: We carried out a nationwide including 24,117 participants aged 60 years older in China using multistage clustered sampling. Dementia AD were diagnosed according fourth edition Diagnostic Statistical Manual Mental Disorders criteria issued by National Institute Neurological Communicative Stroke–Alzheimer's Disease Related...
Abstract Background Evidence on historical trends extracted embedded in recent data can advance our understanding of the epidemiology breast cancer for Chinese women. China is a country with significant political, socioeconomic, and cultural events since 1900s; however, no such studies are reported literature. Methods Age-specific mortality rates during 1990–2015 were analyzed using APC modeling (age-period-cohort modeling) method. Net effect from birth cohort was derived to measure risk...
Abstract Background The combined effects of anticancer drugs with nutritional factors against tumor cells have been reported previously. This study characterized the efficacy and possible mechanisms combination sorafenib vitamin K1 (VK1) on glioma cell lines. Methods We examined sorafenib, VK1 or their proliferation apoptosis human malignant lines (BT325 U251) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, flow cytometry 4′,6-diamidino-2-phenylindole (DAPI)...
Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence and mortality. miR-185, microRNA appriximately 22-28 nucleotides, was reported to be involved in many cancers. The potential mechanism of miR-185 on HCC through cell division cycle 42 (CDC42) investigated. RT-qPCR used measure the RNA level CDC42 tissues cells. dual luciferase reporter assay verify whether target gene for miR-185. Transwell employed detect ability migration invasion change expression low negatively...
To discuss the effect and mechanism of miR-34a on proliferation, apoptosis invasion laryngeal carcinoma cells.The squamous Hep2 cells were transiently transfected with mimics NC. The MTT, colony-forming assay, Hoechst staining AnnexinV-PI double flow cytometry employed to detect viability cells; Transwell assay defect migration western blot RT-PCR expression survivin Ki-67 mRNA in cells.Compared NC group, cell miR-34 group was significantly decreased (P < 0.01), rate increased abilities...
To estimate the unintentional poisoning burden and risk factors in China from 1990 to 2015.We extracted data Global Burden of Disease Study 2015 compare mortality, prevalence, disability-adjusted life years (DALYs), lost, lived with a disability, China. We determined median percent change 95% uncertainty interval for period between 2015.The age-standardized death rate decreased by 61.8% (4.1 per 100 000) (1.6 000). The prevalence (87.9 2010 (39.0 000), but rebounded (42.6 All combined...
Cardiac autophagy inhibitory factor (CAIF) is a novel lncRNA with protective effects on myocardial infarction. We explored the involvement of CAIF in end-stage cardiomyopathy. Patients cardiomyopathy and healthy volunteers were included this study. Myocardial tissues serum collected. was detected by RT-qPCR. ROC curve used for diagnostic analysis. Prognostic value expression evaluated survival Correlations between clinicopathological data patients analysed chi-square test. Downregulated...
Despite the evidence of an association between problematic mobile phone use (PMPU) and psychological symptoms, a few studies explore whether physical activity (PA) could moderate effect PMPU on symptoms its neural substrates. The aim this study was to examine in late adolescents, along with potential moderating PA basis by brain gray matter volume (GMV).A total 251 college students reported their PMPU, PA, subsequently underwent structural magnetic resonance imaging characteristics. A...
Anthropometric parameters and physical activities are significant factors influencing lipid levels, but few research have demonstrated the effect of amount on levels. Our analyzed explored this relationships. A multi-stage stratified sampling method was used to select investigation subjects in Hubei, China. questionnaire survey, measurements biochemistry tests (including total cholesterol, high low-density lipoprotein high-density cholesterol triacylglycerol) were conducted using CCA...
Objective: To estimate the incidence and distribution characteristics of fall related injury in people aged ≥50 years 8 provinces China physiological, psychological social risk factors. Methods: Cross-sectional data were collected from adults participating World Health Organization (WHO) study on global ageing adult health (SAGE) round 1 China. Two-level hierarchical logistic model was used to identify factors for fall-related injury. All models stratified by living area (urban/rural)....
Objective To reflect the correlation between social support and mental health of aged through Pearson coefficient. Methods Databases including PubMed, SpringerLink, EMbase, The Cochrane Library, VIP, WanFang Data CNKI were searched from inception to October, 2011 collect literature on aged. studies screened according inclusion exclusion criteria. After extracting data assessing quality included studies, meta-analysis was conducted using RevMan 5.0 software. Results Of 2 396 identified 4...
Objective: To examine the association between long-term exposure to ambient PM(2.5) combined with indoor air pollution and handgrip strength among people aged 50 over. Methods: Data were from first wave of World Health Organization Study on global AGEing adult health in China. Ambient annual concentration was estimated by using satellite data we also investigated use fuels chimneys as pollution. A two-level (individual level community level) linear model applied strength. Results: total 13...