A5070791510- Cervical Cancer and HPV Research
- Oral microbiology and periodontitis research
- Genital Health and Disease
- Gut microbiota and health
- Sperm and Testicular Function
- Oral Health Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Molecular Biology Techniques and Applications
- Global Cancer Incidence and Screening
- Reproductive tract infections research
- Dental Health and Care Utilization
- Epigenetics and DNA Methylation
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Statistical Methods in Clinical Trials
- Estrogen and related hormone effects
- Dental Radiography and Imaging
- Bone health and treatments
- Bone and Dental Protein Studies
- Reproductive biology and impacts on aquatic species
- DNA Repair Mechanisms
- Hepatitis B Virus Studies
- Opioid Use Disorder Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Cancer Institute
2020-2023
Division of Cancer Epidemiology and Genetics
2020-2023
National Institutes of Health
2020-2022
BioNTech (Germany)
2019
Zhejiang University
2019
Hubei Provincial Center for Disease Control and Prevention
2017
Peking Union Medical College Hospital
2016
Wuhan University
2012
Dartmouth College
1992
The gut microbiota may play a role in breast cancer etiology by regulating hormonal, metabolic and immunologic pathways. We investigated associations of fecal bacteria with nonmalignant disease case-control study conducted Ghana, country rising incidence mortality. To do this, we sequenced the V4 region 16S rRNA gene to characterize samples collected at time biopsy (N = 379 cases, N 102 414 population-based controls). estimated alpha diversity (observed amplicon sequence variants [ASVs],...
// Lu-Lu Yu 1 , Wen Chen Xiao-Qin Lei Qin Ze-Ni Wu Qin-Jing Pan 2 Xun Zhang Bai-Feng Chang Shao-Kai 3 Hui-Qin Guo and You-Lin Qiao Department of Cancer Epidemiology, Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, P. R. China Pathology, Henan Affiliated Hospital Zhengzhou University, Office for Control Research, Zhengzhou, Correspondence to: Guo, email: Qiao, Keywords : cervical cancer; p16/Ki-67 dual staining; human papillomavirus; women; Pathology Section Received...
The oral microbiome, like the fecal may be related to breast cancer risk. Therefore, we investigated whether microbiome was associated with and nonmalignant disease, its relationship in a case-control study Ghana. A total of 881 women were included (369 cancers, 93 cases 419 population-based controls). V4 region 16S rRNA gene sequenced from samples. Alpha-diversity (observed amplicon sequence variants [ASVs], Shannon index Faith's Phylogenetic Diversity) beta-diversity (Bray-Curtis, Jaccard...
Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference oropharyngeal microbiome during acute viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonomic alpha diversity did not differ by infected virus. beta differed disease severity, disease-related symptoms, Nine species had significantly higher abundance outpatients than inpatients, five them genus Achromobacter....
The human fecal and oral microbiome may play a role in the etiology of breast cancer through modulation endogenous estrogen metabolism. This study aimed to investigate associations circulating estrogens metabolites with postmenopausal African women. A total 117 women (N = 110) 114) data measured by 16S rRNA gene sequencing, liquid chromatography tandem mass spectrometry were included. outcomes measures independent variables metabolites. Estrogens associated microbial Shannon index (global P...
The relationship between HPV viral load and histological grades in the development of cervical cancer is argument. It helpful to better understand association by quantitatively detecting HPV16, 18, a pool 12 other high‐risk type (OT) independently on samples precancer cancer. A cross‐sectional study was performed five medical centers China. Histological diagnosis made local pathologists adjudicated via pathology expert panel. fully automated real‐time PCR test used for measurement OT, human...
Abstract Background The causal role of high-risk Human papillomavirus (HR-HPV) in the pathogenesis anogenital cancers is well established. In contrast, information on HR-HPV distribution continuous anatomic sites within female genital tract limited, and impact sample type clinical performance HPV-based cervical cancer screening warrants investigation. Methods A total 2,646 Chinese women were enrolled study from May 2006 to April 2007. We analyzed infection features by status pathological...
This study aims to evaluate the clinical performance of HPV E6/E7 mRNA test in cervical cancer screening China. A hospital-based was conducted with mRNA, DNA, and liquid-based cytology (LBC) as primary tests. Each woman a positive result received colposcopy lesion-targeted-biopsy. Histopathological diagnosis used gold standard. The total agreement DNA 90.7% (95%CI: 87.9, 92.9) kappa value 0.81. rates LBC increased severity histopathology diagnosis, from 25.5, 19.1, 11.4% normal 100.0% SCC,...
Objective A hospital-based multicenter, retrospective study was conducted to compare the distribution of human papillomavirus (HPV) in squamous cell carcinoma (SCC) and cervical adenocarcinoma (CADC) China. Methods Paraffin-embedded tissue blocks diagnosed as SCC CADC across China were collected, well total number invasive cancer 9 selected centers. DNA enzyme immunoassay, reverse hybridization, multiplex type-specific polymerase chain reaction used for HPV genotyping. Results The ratios...
Periodontal disease may be associated with increased breast cancer risk, but studies have not considered invasive and ductal carcinoma in situ (DCIS) separately the same population. We assessed relationship between periodontal a large prospective cohort study. The Sister Study followed women without prior ages 35 to 74 years from 2003 2017 (N = 49,968). Baseline was self-reported, incident ascertained over mean follow-up of 9.3 years. estimated hazard ratios (HR) 95% confidence intervals...
// Lu-Lu Yu 1 , Hui-Qin Guo 2 Xiao-Qin Lei Qin Ze-Ni Wu Le-Ni Kang 3 Xun Zhang You-Lin Qiao and Wen Chen Department of Cancer Epidemiology, National Center, Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, PR China Pathology, Office for Maternal Child Health Surveillance China, West Second University Sichuan University, Chengdu, Correspondence to: Chen, email: Keywords : HPV persistent infection; p16/Ki-67 co-expression; cervical cancer screening Received April 24,...
Safer, more convenient methods for cervical sample collection and storage are necessary to facilitate human papillomavirus (HPV) DNA testing in low-resource settings. Our study aimed evaluate the stability of specimens collected with dry swabs stored dry, compared liquid-based cytology (LBC) samples, as detected by HPV testing. Women abnormal cytological findings or HPV-positive results at colposcopy were recruited from West China Second University Hospital, Sichuan University, between...
Studies have found that periodontal disease and tooth loss are associated with increased mortality; however, associations cause-specific mortality all-cause within specific subgroups not been thoroughly investigated.We examined the association of self-reported disease/decay-related subsequent in Sister Study, a prospective cohort study 50,884 women aged 35-74 years at baseline, whose sister was diagnosed breast cancer. Hazard ratios (HRs) 95% confidence intervals (95% CIs) for were...
HPV‐16 and −18 account for about 80% of cervical cancers. We evaluated the performance HPV‐16/18 oncoprotein to predict precancer cancer in corresponding tissue biopsy specimens. 1,008 women attending screening program 638 referred colposcopy with biopsy‐confirmed intraepithelial neoplasia grade 2 or worse (CIN2+) from 4 hospitals were recruited (1,646 total). All tested Onco E6 (AVC), Liquid‐Based Cytology (Hologic) cobas HPV test (Roche). Colposcopy was performed on any abnormal results....
Cigarette smoking and opium use are associated with periodontal disease caused by specific bacteria such as Porphyromonas gingivalis , which suggests a link between cigarette the oral microbiota. Alterations of microbiota in smokers compared to nonsmokers have been reported, but this has not studied across diverse populations.
Abstract Women with positive high-risk human papillomavirus (hrHPV) need efficient triage testing to determine colposcopy referrals. Triage strategies of combining p16/Ki-67 extended HPV genotyping were evaluated in this study. In total, 899 women attending cervical cancer screening program and 858 referred from five hospitals recruited. All the participants tested by assays dual staining. Colposcopy biopsy performed on any abnormal results. genotypes divided into four strata (HPV16/18,...
An association between high-risk human papillomavirus (HR-HPV) oncoprotein expression and viral persistence has been suggested by the outcome of etiology studies, but there are no epidemiologic studies evaluating that link.We performed a 3-year prospective study in which 2,498 Chinese women ages 25 to 65 years were screened six screening tests, including Onco E6: Cervical Test (Arbor Vita Corporation) 2011 (baseline). Six-hundred ninety who positive for any tests random sample 164 with all...
To estimate the unintentional poisoning burden and risk factors in China from 1990 to 2015.We extracted data Global Burden of Disease Study 2015 compare mortality, prevalence, disability-adjusted life years (DALYs), lost, lived with a disability, China. We determined median percent change 95% uncertainty interval for period between 2015.The age-standardized death rate decreased by 61.8% (4.1 per 100 000) (1.6 000). The prevalence (87.9 2010 (39.0 000), but rebounded (42.6 All combined...
// Hai-Rui Wang 1, 2, * , Yu-Cong Li 3, Hui-Qin Guo 4 Lu-Lu Yu 1 Zeni Wu Jian Yin Guang-Dong Liao 5 Yi-Min Qu 2 Jiang Dong 3 and Wen Chen Department of Cancer Epidemiology, National Center, Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, PR China School Public Health, Gynecological Oncology, Chongqing Institute & Hospital Chongqing, Pathology, Gynecology Obstetrics, The West Second University Sichuan University, Chengdu, These authors have contributed equally to...