A5100390655- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Prostate Cancer Treatment and Research
- Glaucoma and retinal disorders
- Advanced Neuroimaging Techniques and Applications
- Cervical Cancer and HPV Research
- Suicide and Self-Harm Studies
- Genetic Syndromes and Imprinting
- Hepatitis B Virus Studies
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Prostate Cancer Diagnosis and Treatment
- COVID-19 and Mental Health
- Advanced MRI Techniques and Applications
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Fetal and Pediatric Neurological Disorders
- Blood Pressure and Hypertension Studies
- Pituitary Gland Disorders and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Heart Rate Variability and Autonomic Control
Sichuan University
2014-2024
West China Hospital of Sichuan University
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2002-2024
Hubei University of Technology
2024
McGill University Health Centre
2011-2024
Fujian Medical University
2023
Guangzhou Medical University
2009-2023
Southwest Medical University
2023
First Affiliated Hospital of Fujian Medical University
2023
Chengdu University
2023
Maternally expressed gene 3 (MEG3) is an imprinted highly in the human pituitary. However, MEG3 expression lost gonadotroph-derived pituitary adenomas and most tumor cell lines. Expression of cells results growth suppression, p53 protein increase, activation downstream targets. The encodes a noncoding RNA approximately 1700 nucleotides. There are 12 different transcripts, generated by alternative splicing. They contain common exons 1-3 8-10, but each uses one or more 4-7 combination middle....
Abstract Despite advances in characterizing the pathophysiology and genetics of pituitary tumors, molecular mechanisms their pathogenesis are poorly understood. Recently, we isolated a transforming gene [pituitary tumor-transforming (PTTG)] from rat tumor cells. Here describe cloning human PTTG, which is located on chromosome 5q33 shares striking sequence homology with its counterpart. Northern analysis revealed PTTG expression normal adult testis, thymus, colon, small intestine, brain,...
The Dlk1-Gtl2 imprinting locus is located on mouse distal chromosome 12 and consists of multiple maternally expressed non-coding RNAs several paternally protein-coding genes. this plays a crucial role in embryonic development postnatal growth. At least one cis-element, the intergenic differentially methylated region (IG-DMR) required for expression genes repression silenced mechanism by which IG-DMR functions largely unknown. However, it has been suggested that unmethylated acts as positive...
Abstract Although functional and structural abnormalities in brain regions involved the neurobiology of fear anxiety have been observed patients with social disorder (SAD), findings heterogeneous due to small sample sizes, demographic confounders, methodological differences. Besides, multimodal neuroimaging studies on structural-functional deficits couplings are rather scarce. Herein, we aimed explore network anomalies effects structure-function SAD diagnosis. High-resolution magnetic...
Aim Advances in perinatal care and neuroimaging techniques have increased the detection of cerebellar malformations (CBMs) fetus young infant. As a result, this has necessitated greater understanding neurodevelopmental consequences CBMs on child development. The aim study was to delineate impact long-term outcomes. Method We conducted cross-sectional systematically identified children with born between December 2000 2006. then performed follow-up magnetic resonance imaging studies,...
DLK1-MEG3 is an imprinted locus consisting of multiple maternally expressed noncoding RNA genes and paternally protein-coding genes. The expression gene 3 (MEG3) selectively lost in clinically nonfunctioning adenomas (NFAs) gonadotroph origin; however, status other at this human pituitary has not previously been reported. Using quantitative real-time RT-PCR, we evaluated 24 from the 44 (25 NFAs, 7 ACTH-secreting, GH-secreting, 5 PRL-secreting adenomas) 10 normal pituitaries. effects on cell...
Objectives (1) Determine 1‐year period prevalence of suicidal ideation, suicide attempt, and completed among patients newly diagnosed with a first occurrence head neck cancer (HNC). (2) Characterize stability trajectory ideation over the year following diagnosis. (3) Identify at risk ideation. Study Design Prospective longitudinal study follow‐up. Setting Three university‐affiliated outpatient departments otolaryngology–head surgery. Subjects Methods The comprised representative sample 223...
As characterized by repeated exposure of others' trauma, vicarious traumatization is a common negative psychological reaction during the COVID-19 pandemic and plays crucial role in development general mental distress. This study aims to identify functional connectome that encodes individual variations pandemic-related reveal underlying brain-vicarious mechanism predicting The eligible subjects were 105 university students (60 females, aged from 19 27 years) undergoing brain MRI scanning...
Abstract Vicarious traumatization (VT), a negative reaction to witnessing others’ trauma, has been experienced by some people during the COVID-19 pandemic, and can lead mental health problems. This study aimed identify functional brain markers of COVID-specific VT explore psychological mechanism underlying brain-VT link. One hundred healthy participants underwent resting-state magnetic resonance imaging before pandemic (October 2019–January 2020) completed measurement (February–April 2020)....
Dispositional optimism (hereinafter, optimism), as a vital character strength, reflects the tendency to hold generalized positive expectancies for future outcomes. A great number of studies have consistently shown importance spectrum physical and mental health However, less attention has been given intrinsic neurodevelopmental patterns associated with interindividual differences in optimism. Here, we investigated this important question large sample comprising 231 healthy adolescents (16-20...
Transarterial chemoembolization (TACE) is commonly used for treating advanced hepatocellular carcinoma (HCC). However, the instability of lipiodol-drug emulsion and altered tumor microenvironment (TME, such as hypoxia-induced autophagy) postembolization are responsible unsatisfactory therapeutic outcomes. Herein, pH-responsive poly(acrylic acid)/calcium phosphate nanoparticles (PAA/CaP NPs) were synthesized carrier epirubicin (EPI) to enhance efficacy TACE therapy through autophagy...
EEG-based fatigue monitoring can effectively reduce the incidence of related traffic accidents. In past decade, with advancement deep learning, convolutional neural networks (CNN) have been increasingly used for EEG signal processing. However, due to data's non-Euclidean characteristics, existing CNNs may lose important spatial information from EEG, specifically channel correlation. Thus, we propose node-holistic graph network (NHGNet), a model that uses graphic convolution dynamically learn...
Background: The pathophysiological mechanisms underlying postoperative cognitive dysfunction (POCD) remain unclear over the years. Neuroinflammation caused by surgery has been recognized as an important element in development of POCD. Many studies also suggest that vagus nerve plays role transmitting peripheral injury signals to central nervous system (CNS) and resultant neuroinflammation. Previously, we have demonstrated brain mast cells (BMCs), "first responders", play a vital...
Although aberrant brain regional responses are reported in social anxiety disorder (SAD), little is known about resting-state functional connectivity at the macroscale network level. This study aims to identify abnormalities using a multivariate data-driven method relatively large and homogenous sample of SAD patients, assess their potential diagnostic value.Forty-six patients 52 demographically-matched healthy controls (HC) were recruited undergo clinical evaluation MRI scanning. We used...
Traumatic brain injury (TBI) in late adolescence and adulthood is associated with a higher risk of suicide; however, it unknown whether this association also present people who sustained TBI during childhood. The purpose the study was to determine experiencing childhood factor for suicide later life examine differs by sex or severity. A cohort 135,703 children aged 0–17 years identified from Quebec population-based physician reimbursement database 1987, follow-up conducted until 2008. Of...