A5085325387- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Prenatal Screening and Diagnostics
- Moyamoya disease diagnosis and treatment
- Neonatal Respiratory Health Research
- Congenital Heart Disease Studies
- Intracranial Aneurysms: Treatment and Complications
- Electromagnetic Simulation and Numerical Methods
- Traumatic Brain Injury and Neurovascular Disturbances
- Infant Development and Preterm Care
- Neurological Complications and Syndromes
- Coronary Artery Anomalies
- Atomic and Subatomic Physics Research
- Electromagnetic Scattering and Analysis
- Vascular Malformations Diagnosis and Treatment
- Radiation Dose and Imaging
- Microwave Engineering and Waveguides
- Vascular Malformations and Hemangiomas
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Congenital heart defects research
- Medical Imaging Techniques and Applications
- Radiology practices and education
Boston Children's Hospital
2012-2021
Harvard University
2012-2021
Boston Children's Museum
2011-2020
Ochsner Medical Center
2015
Barro Colorado Island
2015
Montreal Neurological Institute and Hospital
2013
McGill University
2009-2011
Children's National
2011
Children's Hospital of Philadelphia
2011
Children's Hospital of Pittsburgh
2011
Adverse neurodevelopmental outcome is an important source of morbidity in children with congenital heart disease (CHD). A significant proportion newborns complex CHD have abnormalities brain size, structure, or function, which suggests that antenatal factors may contribute to childhood morbidity.Brain volume and metabolism were compared prospectively between 55 fetuses 50 normal the use 3-dimensinal volumetric magnetic resonance imaging proton spectroscopy. Fetal intracranial cavity volume,...
Moyamoya syndrome, a narrowing of the basal intracranial vessels accompanied by development cloud collateral "moyamoya" vasculature, causes cerebral ischemia and stroke. This study was undertaken to determine if standardized neurosurgical revascularization procedure, pial synangiosis, conferred long-term benefit in pediatric patients.The authors reviewed clinical radiographic records obtained consecutive series patients with moyamoya syndrome. Patients were 21 years age or younger underwent...
Children with a large vascular tumor and associated Kasabach-Merritt coagulopathy respond inconsistently to therapy have high mortality rate. For this reason, we undertook retrospective study of 21 such patients, focused on clinical, radiographic, histopathologic features. The male female ratio was 1:1.6. Tumor noted at birth in 50 percent patients; the remainder appeared throughout infancy. location cervicofacial (n = 2), shoulder/upper limb 4), trunk including retroperitoneum 11), lower...
Background— We report neuropsychological and structural brain imaging assessments in children 16 years of age with d-transposition the great arteries who underwent arterial switch operation as infants. Children were randomly assigned to a vital organ support method, deep hypothermia either total circulatory arrest or continuous low-flow cardiopulmonary bypass. Methods Results— Of 159 eligible adolescents, 139 (87%) participated. Academic achievement, memory, executive functions,...
OBJECTIVE. The survival of very low birth weight infants has increased markedly in recent years. Unfortunately, the prevalence significant and lifelong motor, cognitive, behavioral dysfunction remained a major problem confronting these children. objective this study was to perform screening tests for early autistic features children with history identify risk factors associated positive result. METHODS. We studied 91 ex-preterm ≤ 1500 g at birth. Infants underwent conventional MRI studies...
Objective. Cognitive impairments and academic failure are commonly reported in survivors of preterm birth. Recent studies suggest an important role for the cerebellum development cognitive social functions. The objective this study was to examine impact prematurity itself, as well prematurity-related brain injuries, on early postnatal cerebellar growth with quantitative MRI. Methods. Advanced 3-dimensional volumetric MRI performed volumes were obtained by manual outlining (<37 weeks)...
OBJECTIVES. The objectives of this study were to delineate the etiologic profile and neurodevelopmental outcome neonatal seizures in current era intensive care identify predictors survivors. METHODS. Eighty-nine term infants with clinical underwent neurologic examination, electroencephalography (EEG), neuroimaging, extensive diagnostic tests newborn period. After discharge, all regular evaluations and, at 12 18 months, formal testing. We tested prognostic value seizure etiology, EEG,...
Objective: To study the risk factors for development of moyamoya syndrome after cranial irradiation primary brain tumors in children.
Neurologic impairment is a major complication of complex congenital heart disease (CHD). A growing body evidence suggests that neurologic dysfunction may be present in significant proportion this high-risk population the early newborn period prior to surgical interventions. We recently provided first brain growth fetuses with CHD has its origins utero. Here, we extend these observations by characterizing global and regional development hypoplastic left syndrome (HLHS), one most severe forms...
Purpose To document the imaging findings associated with congenital Zika virus infection as found in Instituto de Pesquisa Campina Grande State Paraiba (IPESQ) northeastern Brazil, where has been particularly severe. Materials and Methods From June 2015 to May 2016, 438 patients were referred IPESQ for rash occurring during pregnancy or suspected fetal central nervous system abnormality. Patients who underwent at included, well those documented fluid tissue (n = 17, confirmed cohort) brain...
Recent findings from developmental neuroimaging studies suggest that the enhancement of cognitive processes during development may be result a fine-tuning structural and functional organization brain with maturation. However, details regarding trajectory large-scale networks are not yet understood. Here, we used graph theory to examine changes in 203 normally growing children adolescents. Structural were constructed using interregional correlations cortical thickness for 4 age groups (early...
The signal decay with increasing b-factor at fixed echo time from brain tissue in vivo has been measured using a line scan Stejskal–Tanner spin diffusion approach eight healthy adult volunteers. use of 175 ms and maximum gradient strengths 10 mT/m allowed 64 b-factors to be sampled, ranging 5 6000 s/mm2, some three times larger than that typically used for imaging. over this extended range showed decidedly non-exponential behavior well-suited biexponential modeling. Statistical analyses the...
The development and optimization of spin-echo–based, single-slab, three-dimensional techniques for magnetic resonance imaging the whole brain are described. T1-weighted T2-weighted image sets with a volume resolution 1 mm3 fluid-attenuated inversion-recovery 3 were obtained in acquisition times less than 10 minutes per set.
Advanced neuroimaging techniques have brought increasing recognition of cerebellar injury among premature infants. The developmental relationship between early brain and effects on the cerebrum cerebellum remains unclear.To examine whether cerebral parenchymal lesions preterm infants are associated with subsequent decreases in volume and, conversely, primary is decreased volumes, advanced, 3-dimensional, volumetric MRI at term gestational age equivalent.Total volumes gray myelinated white...
PURPOSE: To evaluate with respect to gestational age (GA) the effect of magnetic resonance (MR) imaging on changes in diagnosis, patient counseling, and case management regarding fetuses suspected having central nervous system (CNS) anomalies. MATERIALS AND METHODS: The authors compared images from 242 ultrasonographic (US) studies MR CNS 214 fetuses. Reference standards postnatal physical examination, imaging, surgical, autopsy findings were available 171 (79.9%) Referring physicians...
Cerebellar injury is an important complication of preterm birth with far-reaching neuropsychiatric sequelae. We have previously shown a significant association between isolated to the premature cerebellum and subsequent impairment regional volumetric growth in contralateral cerebrum. In current study, we examine relationship these remote impairments cerebral domain-specific functional deficits children. 40 ex-preterm infants cerebellar injury, performed neurodevelopmental evaluations...
Background— Near-infrared spectroscopy monitoring of cerebral oxygen saturation (rS o 2 ) has become routine in many centers, but no studies have reported the relationship intraoperative near-infrared to long-term neurodevelopmental outcomes after cardiac surgery. Methods and Results— Of 104 infants undergoing biventricular repair without aortic arch reconstruction, 89 (86%) returned for testing at 1 year age. The primary variable was integrated rS (area under curve) ≤45%; secondary...
The relationship between anxious/depressed traits and neuromaturation remains largely unstudied. Characterizing this during healthy neurodevelopment is critical to understanding processes associated with the emergence of child/adolescent onset mood/anxiety disorders. In study, mixed-effects models were used determine longitudinal cortical thickness correlates Child Behavior Checklist (CBCL) Young Adult Self Report Anxious/Depressed scores in children. Analyses included 341 subjects from 4.9...
OBJECTIVE. MRI studies have shown that preterm infants with brain injury altered tissue volumes. Investigation of without offers the opportunity to define influence early birth on development and provide normative data assess effects adverse conditions brain. In this study, we investigated serial low-risk aim identify regions development. METHODS. Twenty-three appropriate for gestational age magnetic resonance–visible underwent twice at 32 42 weeks’ postmenstrual age. Fifteen term were...
The effect of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) was examined on the neurobehavioral, electrophysiological neurostructural development preterm infants with severe intrauterine growth restriction (IUGR). A total 30 infants, 27–33 weeks gestation, were randomized to control (C; N=17) or NIDCAP/experimental (E; N=13) care. Baseline health demographics assessed at intake; electroencephalography (EEG) magnetic resonance imaging (MRI) 35 42 postmenstrual age;...
Background Few studies have described the neuropsychological outcomes and frequency of structural brain or genetic abnormalities in adolescents with single ventricle who underwent Fontan procedure. Methods Results In a cross‐sectional, single‐center study, we enrolled 156 subjects ventricle, mean age 14.5±2.9 years, had undergone Scores entire cohort on standard battery tests were compared those normative populations to group 111 locally recruited healthy adolescents. They also magnetic...
BACKGROUND AND OBJECTIVES:. Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural injury. However, details regarding onset and progression over third trimester are unknown. Our primary objective was to compare third-trimester volumes growth trajectories ex utero without injury healthy fetuses. As a secondary objective, we examined risk factors associated postconception.METHODS:. Preterm born before 32 weeks...