A5102887050- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Prenatal Substance Exposure Effects
- Neurotransmitter Receptor Influence on Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Pain Management and Treatment
- Migraine and Headache Studies
- Language Development and Disorders
- Body Image and Dysmorphia Studies
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Children's Physical and Motor Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cerebral Palsy and Movement Disorders
Neurobehavioral Systems
2013-2023
University of California, Los Angeles
2007-2021
UCLA Health
2004-2019
Triangle
2019
Indianapolis Zoo
2019
Kentucky Science Center
2019
John Wiley & Sons (United States)
2019
University of Vermont
2013
McGill University
2011
University of New Mexico
2011
Recent findings from developmental neuroimaging studies suggest that the enhancement of cognitive processes during development may be result a fine-tuning structural and functional organization brain with maturation. However, details regarding trajectory large-scale networks are not yet understood. Here, we used graph theory to examine changes in 203 normally growing children adolescents. Structural were constructed using interregional correlations cortical thickness for 4 age groups (early...
The relationship between anxious/depressed traits and neuromaturation remains largely unstudied. Characterizing this during healthy neurodevelopment is critical to understanding processes associated with the emergence of child/adolescent onset mood/anxiety disorders. In study, mixed-effects models were used determine longitudinal cortical thickness correlates Child Behavior Checklist (CBCL) Young Adult Self Report Anxious/Depressed scores in children. Analyses included 341 subjects from 4.9...
We used diffusion tensor imaging to investigate fractional anisotropy (FA), a measure of fiber tract integrity, in attention-deficit hyperactivity disorder (ADHD). Using tract-based atlasing approach on six-direction data, we examined FA within the cingulum, corpus callosum, corticospinal tract, fornix, optic radiations, superior longitudinal fasciculus, uncinate and inferior occipitofrontal fasciculi an all-male sample 17 children adolescents with ADHD 16 age-matched controls. patients had...
Abstract Background Repetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown. We explored how concomitant medication use relates clinical response a standard course of rTMS. Methods Medications were tabulated for 181 MDD who underwent six‐week rTMS course. All received 10 Hz left dorsolateral prefrontal cortex (DLPFC), with 1 right DLPFC in...
This study compared frontotemporal brain volumes in children with childhood absence epilepsy (CAE) to age- and gender-matched without epilepsy. It also examined the association of these seizure, demographic, perinatal, intelligence quotient (IQ), psychopathology variables.Twenty-six CAE, aged 7.5-11.8 years, 37 underwent magnetic resonance imaging (MRI) scans at 1.5 Tesla. Tissue was segmented, total brain, frontal lobe, parcellations, temporal lobe were computed. All had IQ testing...
Abstract Obesity and overweight are often defined by the body mass index (BMI), which associates with metabolic cardiovascular disease, possibly dementia as well variations in brain volume. However, fat distribution abdominal obesity (as measured waist circumference) is more strongly correlated risk than BMI. While prior studies have revealed negative associations between gray matter tissue volumes BMI, relationship respect to circumference remains largely unexplored. We therefore...
Recent research in autism spectrum disorder (ASD) has aroused interest anterior cingulate cortex and the neurometabolite glutamate. We report two studies of pregenual (pACC) pediatric ASD. First, we acquired vivo single-voxel proton magnetic resonance spectroscopy (1H MRS) 8 children with ASD 10 typically developing controls who were well matched for age, but fewer males higher IQ. In group midline pACC, found mean 17.7% elevation glutamate + glutamine (Glx) (p<0.05) 21.2% (p<0.001)...
Abstract Repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD) is associated with changes in brain functional connectivity (FC). These may be related to the mechanism action rTMS and explain variability clinical outcome. We examined electroencephalographic FC during first 109 subjects treated 10 Hz left dorsolateral prefrontal cortex. All subsequently received 30 treatments response was defined as ≥40% improvement inventory symptomatology-30 SR...
The purpose of this study was to assess neuroanatomic abnormalities in children and adolescents with childhood-onset schizophrenia by using whole-brain voxel-based morphometric analyses. Previous volumetric studies brain have revealed anomalies similar those subjects adult-onset schizophrenia. Specifically, low cerebral volume, high ventricular thalamic, basal ganglia, callosal, temporal lobe been observed Relatively few anatomical structures delineated measured rare population, partly...
Autism spectrum disorder is a heterogeneous of brain development with wide ranging cognitive deficits. Typically diagnosed before age 3, autism behaviorally defined but patients are thought to have protracted alterations in maturation. With longitudinal magnetic resonance imaging (MRI), we mapped an anomalous developmental trajectory the brains autistic compared those typically developing children and adolescents. Using tensor-based morphometry, created 3D maps visualizing regional tissue...
Abstract Previous magnetic resonance imaging (MRI)‐based volumetric studies have shown age‐related increases in the volume of total white matter and decreases gray normal children. Recent adaptations image analysis strategies enable detection human brain growth with improved spatial resolution. In this article, we further explore spatio‐temporal complexity adolescent maturation tensor‐based morphometry. By utilizing a novel non‐linear elastic intensity‐based registration algorithm on serial...
Intensive cognitive-behavioral therapy (CBT) can effectively reduce symptoms in obsessive-compulsive disorder (OCD). However, many relapse after treatment. Few studies have investigated biological markers predictive of follow-up clinical status. The objective was to determine if brain network connectivity patterns prior intensive CBT predict worsening during follow-up.We acquired resting-state functional magnetic resonance imaging data from 17 adults with OCD and following 4 weeks CBT....
Major depressive disorder (MDD) and chronic pain are highly comorbid, symptoms associated with a poorer response to antidepressant medication treatment. It is unclear whether comorbid also treatment repetitive transcranial magnetic stimulation (rTMS).162 MDD subjects received 30 sessions of 10 Hz rTMS administered the left dorsolateral prefrontal cortex (DLPFC) depression measured before after For subset 96 patients, resting-state electroencephalogram (EEG) was recorded at baseline. Clinical...