A5057406253- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Adolescent and Pediatric Healthcare
- Epilepsy research and treatment
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Maternal Mental Health During Pregnancy and Postpartum
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Schizophrenia research and treatment
- Pharmacological Effects and Toxicity Studies
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Attachment and Relationship Dynamics
- Personality Disorders and Psychopathology
- Hemispheric Asymmetry in Neuroscience
- Stuttering Research and Treatment
- Ultrasound and Cavitation Phenomena
- Posttraumatic Stress Disorder Research
- Resilience and Mental Health
- Advanced MRI Techniques and Applications
Neurobehavioral Systems
2010-2024
University of California, Los Angeles
2010-2024
Gomel Engineering Institute
2018-2021
University of North Carolina at Chapel Hill
2014
Walsh University
2014
University of Miami
2014
National Institutes of Health
2014
Temple University
2005-2008
Objectives: Research has found that bipolar spectrum disorders are associated with Behavioral Approach System (BAS) hypersensitivity and both unipolar depression high Inhibition (BIS) sensitivity, but prospective studies of these relationships lacking. We tested whether BAS BIS sensitivities prospectively predicted the time to new onsets major depressive hypomanic manic episodes in individuals. Methods: followed 136 II or cyclothymic 157 demographically matched normal control individuals for...
In the current study we sought to dissociate component processes of working memory (WM) (vigilance, encoding and maintenance) that may be differentially impaired in attention-deficit/ hyperactivity disorder (ADHD). We collected electroencephalographic (EEG) data from 52 children with ADHD 47 typically developing (TD) children, ages 7-14 years, while they performed a spatial Sternberg task. used independent analysis time-frequency identify midoccipital alpha (8-12 Hz) evaluate frontal midline...
Abstract Language mapping is a key goal in neurosurgical planning. fMRI typically proceeds with focus on Broca's and Wernicke's areas, although multiple other language‐critical areas are now well‐known. We evaluated whether clinicians could use novel approach, including clinician‐driven individualized thresholding, to reliably identify six language regions, Area, Area (inferior, superior), Exner's Supplementary Speech Angular Gyrus, Basal Temporal Area. studied 22 epilepsy tumor patients who...
Transcranial Focused Ultrasound (tFUS) is a promising new potential neuromodulation tool. However, the safety of tFUS has not yet been assessed adequately. Patients with refractory temporal lobe epilepsy electing to undergo an anterior resection present unique opportunity evaluate and efficacy neuromodulation. Histological changes in tissue after can be examined surgical resection, while further concerns using neuropsychological testing.Neuropsychological functions were eight patients before...
The authors examined concurrent and prospective associations of behavioral approach system (BAS)-relevant non-BAS-relevant cognitive styles with bipolar spectrum disorders. Controlling for depressive hypomanic/manic symptoms, 195 individuals disorders scored higher than 194 demographically similar normal controls on BAS sensitivity BAS-relevant dimensions performance concerns, autonomy, self-criticism, but not inhibition approval seeking, sociotropy, dependency. Moreover, group differences...
In this article, we review findings on the role of negative cognitive styles and information processing biases as vulnerabilities to unipolar bipolar mood disorders. We first briefly describe theories depression logic their extension disorders, well methodological issues involved in conducting vulnerability research, particularly with samples. then evidence for styles, processing, rumination, alone combination life events, disorder, developmental antecedents both forms disorder. our review,...
<h3>Importance</h3> Behavioral high-risk phenotypes predict the onset of bipolar disorder among youths who have parents with disorder. Few studies examined whether early intervention delays new mood episodes in youths. <h3>Objective</h3> To determine family-focused therapy (FFT) for is more effective than standard psychoeducation hastening recovery and delaying emergence during 1 to 4 years after an active period symptoms. <h3>Design, Settings, Participants</h3> This multisite randomized...
Objectives This report describes the first comparative double‐blind, placebo‐controlled trial of levothyroxine (L‐T 4 ) and triiodothyronine (T 3 as adjunctive treatments in rapid cycling bipolar disorder. Methods Thirty‐two treatment‐resistant, patients who had failed a lithium were randomized into three treatment arms: L‐T , T or placebo. They followed for ≥4 months with weekly clinical endocrine assessments. Results There no statistically significant differences between groups age,...
Abstract Objective. Intracranially-recorded interictal high-frequency oscillations (HFOs) have been proposed as a promising spatial biomarker of the epileptogenic zone. However, HFOs can also be recorded in healthy brain regions, which complicates interpretation HFOs. The present study aimed to characterize salient features physiological using deep learning (DL). Approach. We studied children with neocortical epilepsy who underwent intracranial strip/grid evaluation. Time-series EEG data...
The underlying mechanisms of alpha band (8-12 Hz) neural oscillations are importance to the functioning attention control systems as well neuropsychiatric conditions that characterized by deficits system, such deficit hyperactivity disorder (ADHD). objectives present study were test if visual encoding-related event-related desynchronization (ERD) correlates with fronto-parieto-occipital connectivity, and whether this is disrupted in ADHD during spatial working memory (SWM) performance. We...
Despite its potential to offer seizure freedom, resective epilepsy surgery (RES) is seldom performed in patients 60 years of age or older. Demonstrating successful outcomes including an improved quality life may raise awareness about the advantages referring this underrepresented population for specialized evaluation. Accordingly, authors investigated and fulfillment with ≥ who had undergone RES.All who, at older, RES medically refractory focal onset seizures authors' center were evaluated....
Aims Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe rationale, design and analytic methods for a 3‐site randomized trial family‐focused treatment youth at high risk (FFT‐HR) BD. Methods Participants (ages 9‐17 years) diagnosis unspecified BD or major depressive disorder, current mood symptoms least one first‐ second‐degree relative with lifetime history I II....
Family-focused therapy (FFT) is associated with enhanced outcomes in youth bipolar and depressive disorders, but has not been evaluated conjunction mobile health tools. In symptomatic adolescents whose parents had histories of mood we examined whether the effects telehealth-based FFT were augmented by apps that emphasized tracking family coping skills.Participants (aged 13-19 years) active symptoms a parent major or disorder. Participants received 12 sessions 18 weeks telehealth FFT, random...