A5041963458- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Family Caregiving in Mental Illness
- Adolescent and Pediatric Healthcare
- Mental Health Treatment and Access
- Chronic Disease Management Strategies
- Primary Care and Health Outcomes
- Health Policy Implementation Science
- Electroconvulsive Therapy Studies
- Mental Health and Patient Involvement
- Health Systems, Economic Evaluations, Quality of Life
- Treatment of Major Depression
- Diabetes Management and Education
- Child and Adolescent Psychosocial and Emotional Development
- Healthcare Policy and Management
- Mental Health Research Topics
- Suicide and Self-Harm Studies
- Interprofessional Education and Collaboration
- Patient Satisfaction in Healthcare
- Psychiatric care and mental health services
- Family Support in Illness
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Digital Mental Health Interventions
- Cardiac Health and Mental Health
pfm medical (Germany)
2025
Harvard University
2015-2024
VA Boston Healthcare System
2014-2023
Lemuel Shattuck Hospital
2023
United States Department of Veterans Affairs
1997-2023
Boston University
1992-2022
Research Network (United States)
2021
Quality Enhancement Research Initiative
2016-2021
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2011-2020
Technische Universität Dresden
2011-2020
Objectives: This study proposes methods for blending design components of clinical effectiveness and implementation research. Such can provide benefits over pursuing these lines research independently; example, more rapid translational gains, effective strategies, useful information decision makers. a "hybrid effectiveness-implementation" typology, describes rationale their use, outlines the decisions that must be faced, provides several real-world examples. Results: An...
The movement of evidence-based practices (EBPs) into routine clinical usage is not spontaneous, but requires focused efforts. field implementation science has developed to facilitate the spread EBPs, including both psychosocial and medical interventions for mental physical health concerns. authors aim introduce principles non-specialist investigators, administrators, policymakers seeking become familiar with this emerging field. This introduction based on published literature authors'...
OBJECTIVE: The term "mood stabilizer" is widely used in the context of treating bipolar disorder, but U.S. Food and Drug Administration (FDA) does not officially recognize term, no consensus definition accepted among investigators. authors propose a "two-by-two" by which an agent considered mood stabilizer if it has efficacy acute manic depressive symptoms prophylaxis disorder. They review literature on agents any these four roles to determine meet this stabilizer. METHOD: conducted...
We describe the use of a conceptual framework and implementation protocol to prepare effective health services interventions for in community-based (i.e., non-academic-affiliated) settings. The is based on experiences U.S. Centers Disease Control Prevention (CDC) Replicating Effective Programs (REP) project, which has been at forefront developing systematic strategies HIV dissemination. This article describes REP framework, how it can be applied implement clinical organizations. consists...
We report the reliability and validity of Internal State Scale, a self-report instrument for simultaneous assessment severity manic depressive symptoms. The Scale consists four empirically derived subscales: Activation, Well-Being, Perceived Conflict, Depression Index. All subscales had good internal consistency reliability. Activation subscale scores were significantly higher in patients than depressed or control subjects, while Well-Being lower Index other two groups. correlated...
This study examined the relationships between positive emotions and health. Two were considered, hope curiosity, in conjunction with 3 physician-diagnosed disease outcomes: hypertension, diabetes mellitus, respiratory tract infections. Medical data abstracted over a 2-year period from 1,041 patient records multispecialty medical practice, assessed through mailed questionnaire. Across outcomes, higher levels of associated decreased likelihood having or developing disease. Higher curiosity...
Background: The use of telemental health via videoconferencing (TMH-V) became critical during the Coronavirus disease 2019 (COVID-19) pandemic due to restriction non-urgent in-person appointments. current brief report demonstrates rapid growth in TMH-V appointments weeks following declaration within Department Veterans Affairs (VA), largest healthcare system United States. Methods: COVID-19 changes were captured six World Health Organization's (March 11, 2020-April 22, 2020). Pre-COVID-19...
A s summarized in the companion article for this report (1), bipolar disorder is common, chronic, and associated with substantial morbidity health care costs.As management of other chronic medical illnesses, cornerstone evidence-based pharmacotherapy (2).However, there a gap between efficacy interventions seen clinical trials their effectiveness real-world practice (3-10).Modest response rates recent large suggest that medication strategies alone will not be sufficient to close (11),...
Context: Despite the availability of efficacious treatments, long-term course bipolar disorder is often unfavorable.Objective: To test effectiveness a multicomponent intervention program to improve quality care and outcomes for persons with disorder.Design: Randomized controlled trial allocation concealment blinded outcome assessment.
OBJECTIVE: Clinicians have few evidence-based options for the management of treatment-resistant bipolar depression. This study represents first randomized trial competing depression and assesses effectiveness safety antidepressant augmentation with lamotrigine, inositol, risperidone. METHOD: Participants (N=66) were patients I or II disorder enrolled in NIMH Systematic Treatment Enhancement Program Bipolar Disorder (STEP-BD). All a current major depressive episode that was nonresponsive to...
• Thirty patients with rapid cycling bipolar affective disorder were studied prospectively to assess presence and severity of thyroid hypofunction. Seven (23%) classified as having grade I hypothyroidism, while 8 (27%) had II 3 (10%) III abnormalities. This prevalence hypothyroidism is significantly greater than that reported in studies unselected during long-term treatment lithium carbonate, although only 63% this sample was taking carbonate or carbamazepine. The association cannot be...
Comorbid medical conditions, notably cardiovascular disease, occur disproportionately among persons with bipolar disorder; yet the quality and outcomes of care for these individuals are suboptimal. This pilot study examined a disorder model (BCM) determined whether, compared usual care, randomly assigned to receive BCM had improved psychiatric outcomes.Persons disease-related risk factors were recruited from large Department Veterans Affairs mental health facility or care. consisted four...
Presentation This article summarizes the three types of hybrid effectiveness-implementation designs and associated evaluation methods. It includes a discussion how have potential to enhance knowledge development application clinical interventions implementation strategies in “real world” settings. The authors propose implications for qual
Despite the availability of psychosocial evidence-based practices (EBPs), treatment and outcomes for persons with mental disorders remain suboptimal. Replicating Effective Programs (REP), an effective implementation strategy, still resulted in less than half sites using EBP. The primary aim this cluster randomized trial is to determine, among not initially responding REP, effect adaptive strategies that begin External Facilitator (EF) or plus Internal (IF) on improved EBP use patient 12...
The months after psychiatric hospital discharge are a time of high risk for suicide. Intensive postdischarge case management, although potentially effective in suicide prevention, is likely to be cost-effective only if targeted at high-risk patients. A previously developed machine learning (ML) model showed that suicides can predicted from electronic health records and geospatial data, but it unknown prediction could improved by adding additional information. To determine whether information...