A5011806829- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Photoreceptor and optogenetics research
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Blood Coagulation and Thrombosis Mechanisms
- Birth, Development, and Health
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
- Epilepsy research and treatment
- Gene expression and cancer classification
- Infant Nutrition and Health
Children's National
2016-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2025
Research Network (United States)
2025
George Washington University
2015-2024
Lund University
2022
Ben-Gurion University of the Negev
2022
Soroka Medical Center
2022
Universitair Ziekenhuis Leuven
2022
KU Leuven
2022
Cornell University
2021
A fundamental question in synaptic physiology is whether the unitary strength of a synapse can be regulated by presynaptic characteristics and, if so, what those might be. Here, we characterize newly proposed mechanism for altering glutamatergic synapses based on recently identified vesicular glutamate transporter VGLUT1. We provide direct evidence that filling isolated vesicles subject to dynamic equilibrium determined both concentration available and number transporters participating...
BACKGROUND AND OBJECTIVES:. Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural injury. However, details regarding onset and progression over third trimester are unknown. Our primary objective was to compare third-trimester volumes growth trajectories ex utero without injury healthy fetuses. As a secondary objective, we examined risk factors associated postconception.METHODS:. Preterm born before 32 weeks...
Brain structural changes in premature infants appear before term age. Functional differences between and healthy fetuses during this period have yet to be explored. Here, we examined brain connectivity using resting state functional MRI 25 very (VPT; gestational age at birth <32 weeks) with structurally normal MRIs. Resting data were evaluated seed-based correlation analysis network-based statistics 23 regions of interest (ROIs) per hemisphere. strength, the Pearson blood oxygenation level...
Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders delays even in the absence of structural brain injuries. These risks may be due to earlier-than-typical exposure extrauterine environment, its bright lights, loud noises, exposures painful procedures. Given relative underdeveloped pain modulatory responses these infants, frequent confer later deficits.
Pol III-related leukodystrophies are caused by mutations in POLR3A and POLR3B genes all share peculiar imaging clinical features. The objectives of this study (1) to define the neuroradiologic pattern a cohort subjects (2) compare with other hypomyelinating disorders. magnetic resonance (MRI) examinations 13 patients 14 disorders were analyzed. All presented hypomyelination associated T2 hypointensity thalami and/or pallida. Twelve (92%) optic radiations. Cerebellar atrophy was observed most...
To compare regional cerebral cortical microstructural organization between preterm infants at term-equivalent age (TEA) and healthy full-term newborns, to examine the impact of clinical risk factors on micro-organization in cohort. We prospectively enrolled very (gestational (GA) birth<32 weeks; birthweight<1500 g) controls. Using non-invasive 3T diffusion tensor imaging (DTI) metrics, we quantified ten areas: medial/dorsolateral prefrontal cortex, anterior/posterior cingulate insula,...
Abstract Congenital heart disease (CHD) is an independent risk factor for brain injury, including stroke, and poor neurodevelopmental outcomes, placental abnormalities may represent additional injury in neonates. The incidence scope of pathology relationship to fetal pregnancies complicated by CHD has not been explored our knowledge. In order determine the prevalence findings whether are associated with postnatal CHD, we reviewed reports 51 scored available postnatal, pre-operative MRI...
Premature birth is associated with high prevalence of neurodevelopmental impairments in surviving infants. The putative role cerebellar and brainstem dysfunction remains poorly understood, particularly the absence overt structural injury. We compared in-utero versus ex-utero global, regional local development healthy fetuses (n = 38) prematurely born infants without evidence brain injury on conventional MRI studies 74) that were performed at two time points: first corresponding to third...
Importance The neonatal brain injury score on magnetic resonance imaging following moderate or severe hypoxic-ischemic encephalopathy developed by the National Institute of Child Health and Human Development Neonatal Research Network has been revised to separate watershed basal ganglia thalamic their associated outcomes. Objective To evaluate association with outcomes death disability among all infants, neurodevelopment survivors in a trial deeper longer cooling. Design, Setting,...
Acridine orange in dilute aqueous solution is used as a vital stain to distinguish and differentiate three populations of leukocytes from all other formed elements the blood. Counts first third these with an automated cytofluorometer correlate well manual lymphocyte granulocyte counts on Wright-Giemsa-stained smears. second population are systematically higher than monocytes, for reasons that discussed. Reproducibility much better differential cells stained acridine Staining simple,...
Importance Elevated maternal psychological distress during pregnancy is associated with altered fetal brain development. During the COVID-19 pandemic, prenatal more than doubled. Objective To examine association of pandemic and rising growth in newborns using quantitative 3-dimensional volumetric magnetic resonance imaging (MRI). Design, Setting, Participants This prospective cross-sectional study recruited mother-infant dyads at Children’s National Hospital, Washington, DC, (June 1, 2020,...
Background Due to random motion of fetuses and maternal respirations, image quality fetal brain MRIs varies considerably. To address this issue, visual inspection the images is performed during acquisition phase after 3D‐reconstruction, are re‐acquired if they deemed be insufficient quality. However, process time‐consuming subjective. Multi‐instance (MI) deep learning methods (DLMs) may perform task automatically. Purpose propose an MI count‐based DLM (MI‐CB‐DLM), vote‐based (MI‐VB‐DLM),...
OBJECTIVE Previous studies have demonstrated that an important factor in seizure freedom following surgery for lesional epilepsy the peri-eloquent cortex is completeness of resection. However, aggressive resection epileptic tissue localized to this region must be balanced with competing objective retaining postoperative neurological functioning. The study was investigate role intraoperative MRI (iMRI) as a complement existing protocol techniques and compare rates deficit pediatric patients...
OBJECTIVE Previous meta-analysis has demonstrated that the most important factor in seizure freedom following surgery for focal cortical dysplasia (FCD) is completeness of resection. However, intraoperative detection epileptogenic dysplastic tissue remains a challenge, potentially leading to partial resection and need reoperation. The objective this study was determine role MRI (iMRI) localization FCD as well its impact on surgical decision making, resection, control outcomes. METHODS...
Gamma-aminobutyric acid (GABA) and glutamate are principal neurotransmitters essential for late gestational brain development may play an important role in prematurity-related injury. In vivo investigation of GABA the preterm infant with standard proton magnetic resonance spectroscopy (1H-MRS) has been limited due to its low concentrations developing brain, overlap spectrum by other dominant metabolites. We describe early postnatal profiles measured using J-difference editing technique,...
Despite recent advances in nutrition practice the neonatal intensive care unit, infants remain at high risk for growth restriction following preterm birth. Additionally, optimal values macronutrient administration, especially lipid intake, have yet to be established extrauterine environment.We studied born very low-birth weight (VLBW, <1500 g) and ≤32 weeks' gestation. Cumulative (carbohydrate, lipid, protein, energy) intake first 2 4 weeks of life was compared with total regional brain...
This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (1H-MRS). We explore associations between altered metabolite brain injury topography, severity of injury, prematurity-related clinical complications. prospectively collected high quality 1H-MRS 59 premature born ≤32 weeks 61 full controls. data were processed LCModel software calculate...
Background The third trimester of gestation is a crucial phase rapid brain development, but little has been reported on the trajectories cerebral blood flow (CBF) in preterm infants this period. Purpose To quantify regional CBF very longitudinally across ex utero and to determine its relationship with clinical factors associated injury premature birth. Materials Methods In prospective study, were enrolled for three longitudinal MRI scans, 22 healthy full-term one term scan between November...