Sara B. DeMauro
A5041950620- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Congenital Heart Disease Studies
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Conditions and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare Technology and Patient Monitoring
- Non-Invasive Vital Sign Monitoring
- Child and Adolescent Health
- Clinical Nutrition and Gastroenterology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cerebrospinal fluid and hydrocephalus
- Breastfeeding Practices and Influences
- Mechanical Circulatory Support Devices
- Retinopathy of Prematurity Studies
- Fetal and Pediatric Neurological Disorders
- Emergency and Acute Care Studies
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2025
Research Network (United States)
2017-2025
Philadelphia University
2014-2025
Hospital of the University of Pennsylvania
2013-2025
Health and Human Development (2HD) Research Network
2020-2025
Cohort (United Kingdom)
2024-2025
Pennsylvania Hospital
2012-2024
Emory University
2016-2024
<h3>Importance</h3> Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. <h3>Objective</h3> To review 20-year trends in maternal/neonatal care, complications, mortality among extremely born at Neonatal Research Network centers. <h3>Design, Setting, Participants</h3> Prospective registry of 34 636 infants, 22 28 weeks' gestation, birth weight 401 1500 g, 26 network centers between 1993 2012. <h3>Exposures</h3> birth. <h3>Main Outcomes Measures</h3>...
Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, adequately predict childhood morbidity.
Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately neonatal mortality and childhood morbidity. To review survival, in-hospital morbidities, care practices, neurodevelopmental functional outcomes at 22-26 months' corrected age for infants. Prospective registry born 19 US academic centers that are part of the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. The study included 10 877...
Hypothermia for 72 hours at 33.5°C neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high. To determine if cooling 120 a temperature of 32.0°C disability age 18 months in infants with encephalopathy. Randomized 2 × factorial clinical trial neonates (≥36 weeks' gestation) US centers the Eunice Kennedy Shriver National Institute Child Health and Human Development Neonatal Research Network between October 2010 January 2016. A total 364 were randomly...
OBJECTIVES:Evaluate the spectrum of neurodevelopmental outcome in a contemporary cohort extremely preterm infants. We hypothesize that rate severe impairment (NDI) decreases over time.
Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment the second postnatal week can improve survival without bronchopulmonary and adverse neurodevelopmental effects unknown. We conducted trial involving infants who had gestational age of less than 30 weeks been intubated for at least 7 days 14 28 days. Infants were randomly assigned receive either (4 mg...
Importance Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared formula. For receiving no or minimal maternal milk, it is unknown whether donor human conveys similar advantages vs Objective To determine if nutrient-fortified, pasteurized improves at 22 to 26 months’ corrected age infant formula among who received milk. Design, Setting, and Participants Double-blind, randomized clinical trial...
Importance Hypothermia begun less than 6 hours after birth reduces death or disability in infants with encephalopathy due to hypoxia-ischemia at 36 more weeks’ gestation. Trials of hypothermia for younger gestation are lacking. Objective To assess the probability that decreases 33 35 moderate severe hypoxic-ischemic encephalopathy. Design, Setting, and Participants This randomized clinical trial was conducted between July 2015 December 2022 birth. Bayesian intention-to-treat analyses were...
Extubation failure is common in extremely preterm infants. The current paucity of data on the adverse long-term respiratory outcomes associated with reinitiation mechanical ventilation prevents assessment risks and benefits a trial extubation this population.To evaluate whether exposure to multiple courses increases risk before after adjustment for cumulative duration ventilation.We performed retrospective cohort study low-birth-weight (ELBW; birth weight <1000 g) infants born from January...
Objective: The aim of this study was to determine which initial surgical treatment results in the lowest rate death or neurodevelopmental impairment (NDI) premature infants with necrotizing enterocolitis (NEC) isolated intestinal perforation (IP). Summary Background Data: impact laparotomy versus peritoneal drainage for NEC IP on NDI extremely low birth weight is unknown. Methods: We conducted largest feasible randomized trial 20 US centers, comparing drainage. primary outcome a composite at...
Among extremely preterm infants, we evaluated whether bevacizumab therapy compared with surgery for retinopathy of prematurity (ROP) is associated adverse outcomes in early childhood.
Racial/ethnic disparities in quality of care among extremely preterm infants are associated with adverse outcomes. To assess whether racial/ethnic major outcomes and key practices were changing over time infants. This observational cohort study used prospectively collected data from 25 US academic medical centers. Participants included 20 092 22 to 27 weeks' gestation a birth weight 401 1500 g born at centers participating the National Institute Child Health Human Development Neonatal...
Preterm infants with bronchopulmonary dysplasia (BPD), and particularly those who develop the most severe forms of chronic lung disease during neonatal period, are at high risk for poor developmental outcomes throughout childhood. Infants require mechanical ventilation 36 weeks post-menstrual age have significantly increased odds cerebral palsy, delay 2 years, academic achievement low intelligence quotient in adolescence. Over past several decades, many therapies care strategies, including...
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are adverse neurologic outcomes low-risk infants. Whether this association exists contemporary practice is uncertain because most randomized clinical trials administered earlier and higher doses than currently recommended. Objective To evaluate whether the pretreatment death or grade 2 3 BPD 36 weeks’...
To compare the incidence of postdischarge feeding dysfunction and hospital/subspecialty visits for problems during first year life in late (34 to 36 6/7 weeks) early-preterm (25 33 infants.In this prospective study, authors sent questionnaires parents early (n = 319) 571) preterm infants at 3, 6, 12 months corrected age. Parents' perceptions infants' skills, comfort with feeding, difficulties were obtained. Results analyzed χ(2) tests Spearman's correlations.Early preterms had more oromotor...
Events in the delivery room significantly impact outcomes of preterm infants. We developed evidence-based guidelines to prevent heat loss, reduce exposure supplemental oxygen, and increase use noninvasive respiratory support improve care infants with birth weight ≤1250 g at our institution.The were implemented through multidisciplinary conferences, routine a checklist, appointment dedicated resuscitation nurse, frequent feedback clinicians. This cohort study compares historical group (n =...
Birth weight (BW) is an important predictor of mortality and morbidity. At extremely early gestational ages (GAs), BW may influence decisions regarding initiation resuscitation. To characterize outcomes liveborn infants with a less than 400 g. This retrospective multicenter cohort study analyzed preterm born between January 2008 December 2016 within the National Institute Child Health Human Development Neonatal Research Network. Infants g GA 22 to 26 weeks were included. Active treatment was...
Obstet Gynecol Surv 2016;71(1):7–9 Since the 1990s, there have been considerable changes in care for mothers preterm labor and extremely infants. The Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network has monitored this more than 2 decades and, most recently, evaluated data from 2003 to 2007.
To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small gestational age (SGA) among very preterm infants, stratified by completed weeks gestation.Retrospective cohort study using Optum Neonatal Database. Study infants were born <32 gestation without severe congenital anomalies. SGA was defined as a weight <10th percentile. The outcome babies...
OBJECTIVES: To compare medical and developmental outcomes over the first 2 years of life in extremely preterm infants with bronchopulmonary dysplasia (BPD) who were discharged on supplemental oxygen via nasal cannula a similar severity respiratory illness breathing room air. METHODS: We performed propensity score–matched cohort study. Eligible born at &lt;27 weeks’ gestation, receiving or support 36 postmenstrual age, assessed 18 to 26 months’ corrected age. Study included growth,...
Determine risk of death or neurodevelopmental impairment (NDI) in infants with late-onset sepsis (LOS) versus late-onset, antibiotic-treated, blood culture-negative conditions (LOCNC).Retrospective cohort study.24 neonatal centres.Infants born 1/1/2006-31/12/2014, at 22-26 weeks gestation, birth weight 401-1000 g and surviving >7 days were included. Infants early-onset sepsis, necrotising enterocolitis, intestinal perforation both LOS LOCNC excluded.LOS defined as antibiotic administration...