A5005768091- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Infant Nutrition and Health
- Birth, Development, and Health
- Infant Health and Development
- Language Development and Disorders
- Ear Surgery and Otitis Media
- Breastfeeding Practices and Influences
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Gestational Diabetes Research and Management
- Child and Adolescent Health
- Neonatal Health and Biochemistry
- Assisted Reproductive Technology and Twin Pregnancy
- Family and Disability Support Research
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Noise Effects and Management
- Cerebral Palsy and Movement Disorders
- Obesity, Physical Activity, Diet
- Child Nutrition and Feeding Issues
Research Network (United States)
1998-2025
Women & Infants Hospital of Rhode Island
2016-2025
Brown University
2016-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2005-2025
Providence College
2015-2024
Duke University
2012-2023
Stanford University
2004-2023
University of Iowa
2011-2023
Lucile Packard Children's Hospital
2012-2023
The University of Texas Southwestern Medical Center
2012-2023
Childhood obesity has contributed to an increased incidence of type 2 diabetes mellitus and metabolic syndrome (MS) among children. Intrauterine exposure size at birth are risk factors for mellitus, but their association with MS in childhood not been demonstrated. We examined the development large-for-gestational-age (LGA) appropriate-for-gestational age (AGA) children.The major components (obesity, hypertension, dyslipidemia, glucose intolerance) were evaluated a longitudinal cohort study...
OBJECTIVES. The objectives of this study were to assess whether (1) in-hospital growth velocity is predictive neurodevelopmental and outcomes at 18 22 months’ corrected age among extremely low birth weight (ELBW) infants (2) contributes these after controlling for confounding demographic clinical variables. METHODS. Infants 501 1000 g from a multicenter cohort divided into quartiles rates. Variables considered the logistic-regression models included gender, race, gestational age, small...
Objectives. The purposes of this study were to report the neurodevelopmental, neurosensory, and functional outcomes 1151 extremely low birth weight (401–1000 g) survivors cared for in 12 participating centers National Institute Child Health Human Development Neonatal Research Network, identify medical, social, environmental factors associated with these outcomes. Study Design. A multicenter cohort which surviving infants born 1993 1994 underwent assessment at 18 22 months' corrected age....
Objective. A number of definitions bronchopulmonary dysplasia (BPD), or chronic lung disease, have been used. June 2000 National Institute Child Health and Human Development/National Heart, Lung, Blood Workshop proposed a severity-based definition BPD for infants <32 weeks’ gestational age (GA). Mild was defined as need supplemental oxygen (O2) ≥28 days but not at 36 postmenstrual (PMA) discharge, moderate O2 plus treatment with <30% PMA, severe ≥30% and/or positive pressure...
Objectives. Necrotizing enterocolitis (NEC) is a significant complication for the premature infant. However, subsequent neurodevelopmental and growth outcomes of extremely low birth weight (ELBW) infants with NEC have not been well described. We hypothesized that ELBW surgically managed (SurgNEC) are at greater risk poor than medically (MedNEC) compared without history (NoNEC). The objective this study was to compare growth, neurologic, cognitive among survivors SurgNEC MedNEC NoNEC 18 22...
We previously reported early results of a randomized trial whole-body hypothermia for neonatal hypoxic–ischemic encephalopathy showing significant reduction in the rate death or moderate severe disability at 18 to 22 months age. Long-term outcomes are now available.
Between-hospital variation in outcomes among extremely preterm infants is largely unexplained and may reflect differences hospital practices regarding the initiation of active lifesaving treatment as compared with comfort care after birth. We studied born between April 2006 March 2011 at 24 hospitals included Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. Data were collected for 4987 before 27 weeks gestation without congenital anomalies....
OBJECTIVE. Beneficial effects of breast milk on cognitive skills and behavior ratings have been demonstrated previously in term very low birth weight infants. Extremely infants are known to be at increased risk for developmental morbidities. The benefits that is ingested the NICU by extremely development not evaluated previously. METHODS. Nutrition data including enteral parenteral feeds were collected prospectively, follow-up assessments 1035 18 months’ corrected age completed 15 sites...
OBJECTIVE. We sought to evaluate the association between early protein and energy intake neurodevelopment growth of extremely low birth weight (<1000 g) infants. STUDY DESIGN. Daily intakes were collected by chart review for first 4 weeks life on 148 survivors. A total 124 infants (84%) returned evaluation at 18 months' corrected age. Bivariate analysis tested correlations weekly or Bayley Mental Development Index, Psychomotor months. Separate regression models evaluated contributions...
BACKGROUND. We previously reported beneficial effects of breast milk ingestion by infants with extremely low birth weight in the NICU on developmental outcomes at 18 months’ corrected age. The objective this study was to determine whether these persisted 30 METHODS. Nutrition data, including enteral and parenteral feeds, were prospectively collected, age follow-up assessments completed 773 who participated National Institute Child Health Human Development Neonatal Research Network Glutamine...
Data reported during the past 5 years indicate that rates of survival have increased among infants born at borderline viability, but less is known about how these relate to early childhood neurodevelopmental outcomes. We compared and outcomes 22 24 weeks gestation, as assessed 18 months corrected age, across three consecutive birth-year epochs (2000-2003 [epoch 1], 2004-2007 2], 2008-2011 3]). The were 11 centers participated in National Institute Child Health Human Development Neonatal...
Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately neonatal mortality and childhood morbidity. To review survival, in-hospital morbidities, care practices, neurodevelopmental functional outcomes at 22-26 months' corrected age for infants. Prospective registry born 19 US academic centers that are part of the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. The study included 10 877...
Objective. This study evaluated the impact of changes in perinatal management on neurodevelopmental impairment (NDI) at 18 to 22 months’ corrected age low gestation (22–26 weeks) and higher (27–32 extremely birth weight infants (401–1000 g weight) who were cared for National Institute Child Health Human Development Neonatal Research Network during 3 epochs (1993–1994, 1995–1996, 1997–1998). It was hypothesized that outcomes would improve over epochs. Methods. A multicenter cohort conducted...
OBJECTIVE. This study compared the effects of immediate (ICC) and delayed (DCC) cord clamping on very low birth weight (VLBW) infants 2 primary variables: bronchopulmonary dysplasia (BPD) suspected necrotizing enterocolitis (SNEC). Other outcome variables were late-onset sepsis (LOS) intraventricular hemorrhage (IVH). STUDY DESIGN. was a randomized, controlled unmasked trial in which women labor with singleton fetuses <32 weeks’ gestation randomly assigned to ICC (cord clamped at 5–10...
Objectives. Parenchymal involvement of intraventricular hemorrhage (IVH) is a major risk factor for neurodevelopmental handicap in very low birth weight neonates. Previous trials have suggested that indomethacin would lower the incidence and severity IVH Methods. We enrolled 431 neonates 600- to 1250-g with no evidence at 6 11 hours age prospective, randomized, placebo-controlled trial test hypothesis low-dose (0.1 mg/kg intravenously 12 postnatal every 24 two more doses) IVH. Serial cranial...
Current guidelines, initially published in 1995, recommend antenatal corticosteroids for mothers with preterm labor from 24 to 34 weeks' gestational age, but not before weeks due lack of data. However, many infants born gestation are provided intensive care.To determine if use is associated improvement major outcomes at 22 and 23 gestation.Cohort study data collected prospectively on inborn a birth weight between 401 g 1000 (N = 10,541) 25 January 1, 1993, December 31, 2009, academic...
OBJECTIVES: Quantity of talk and interaction in the home during early childhood is correlated with socioeconomic status (SES) can be used to predict language cognitive outcomes. We tested effectiveness automated environment estimates for children 2 36 months old skills 10 years later examined effects specific developmental age periods. METHODS: Daylong audio recordings 146 infants toddlers were completed monthly 6 months, total number daily adult words adult-child conversational turnswere...
To determine the sound environment of preterm infants cared for in NICU and to test hypothesis that exposed more adult language will make vocalizations.This was a prospective cohort study 36 who had birth weight ≤1250 g. Sixteen-hour recordings infant were made from digital processor at 32 weeks' postmenstrual age. Adult word counts, vocalizations, conversational turns analyzed.Infant vocalizations are present as early weeks. Both counts per hour increase significantly between Infant...
Extremely preterm infants are at risk for neurodevelopmental impairment (NDI). Early cranial ultrasound (CUS) is usual practice, but near-term brain MRI has been reported to better predict outcomes. We prospectively evaluated white matter abnormality (WMA) and cerebellar lesions, serial CUS adverse findings as predictors of outcomes 18 22 months' corrected age. late CUS, were read by masked central readers, in a large cohort (n = 480) <28 weeks' gestation surviving near term the Neonatal...
This document is a supplement to the recommendations in year 2007 position statement of Joint Committee on Infant Hearing (JCIH)1 and provides comprehensive guidelines for early hearing detection intervention (EHDI) programs establishing strong (EI) systems with appropriate expertise meet needs children who are deaf or hard (D/HH).EI services represent purpose goal entire EHDI process. Screening confirmation that child D/HH largely meaningless without appropriate, individualized, targeted...
The goal of this study was to test the association mean adult word counts at 32 and 36 weeks' postmenstrual age in NICU with Bayley Scales Infant Toddler Development, 3rd Edition (Bayley-III), cognitive language scores. It hypothesized that preterm infants exposed higher would have scores 7 18 months' corrected age.This prospective cohort included a birth weight ≤1250 g. Sixteen-hour recordings were made by using digital processor age. Regression analyses performed on count per hour,...
OBJECTIVES:Evaluate the spectrum of neurodevelopmental outcome in a contemporary cohort extremely preterm infants. We hypothesize that rate severe impairment (NDI) decreases over time.