A5103248030- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Sepsis Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Congenital Heart Disease Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Birth, Development, and Health
- Streptococcal Infections and Treatments
- Pediatric Pain Management Techniques
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Retinopathy of Prematurity Studies
- Pulmonary Hypertension Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Facial Rejuvenation and Surgery Techniques
- Pneumonia and Respiratory Infections
- Infant Health and Development
- Cardiac Arrest and Resuscitation
Duke University
2006-2025
Health and Human Development (2HD) Research Network
2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021-2025
Research Network (United States)
2021-2025
Duke University Hospital
2002-2024
Duke Medical Center
2007-2023
Children's Healthcare of Atlanta
2018
Indiana University – Purdue University Indianapolis
2018
Stanford University
2018
Emory University
2018
Our objectives were to identify factors associated with the duration of first antibiotic course initiated in 3 postnatal days and assess associations between initial subsequent necrotizing enterocolitis or death extremely low birth weight infants sterile culture results.We conducted a retrospective cohort analysis admitted tertiary centers 1998-2001. We defined empirical treatment as continuous therapy started results. used descriptive statistics characterize center practice, bivariate...
Current guidelines, initially published in 1995, recommend antenatal corticosteroids for mothers with preterm labor from 24 to 34 weeks' gestational age, but not before weeks due lack of data. However, many infants born gestation are provided intensive care.To determine if use is associated improvement major outcomes at 22 and 23 gestation.Cohort study data collected prospectively on inborn a birth weight between 401 g 1000 (N = 10,541) 25 January 1, 1993, December 31, 2009, academic...
OBJECTIVE. The goal was to determine whether the risk of death or moderate/severe disability in term infants with hypoxic-ischemic encephalopathy increases relatively high esophageal skin temperature occurring between 6 and 78 hours after birth. METHODS. This an observational secondary study within National Institute Child Health Human Development Neonatal Research Network randomized trial comparing whole-body cooling usual care (control) for encephalopathy. Esophageal temperatures were...
It remains controversial as to whether neonatal seizures have additional direct effects on the developing brain separate from severity of underlying encephalopathy. Using data collected infants diagnosed with hypoxic-ischemic encephalopathy, and who were enrolled in an National Institute Child Health Human Development trial hypothermia, we analyzed associations between clinical outcomes at 18 months age. Of 208 enrolled, 102 received whole body hypothermia 106 controls. Clinical generally...
Cerebral palsy (CP) has a significant impact on both patients and society, but therapy is limited. Human umbilical cord blood cells (HUCBC), containing various stem progenitor cells, have been used to treat brain genetic conditions. In small animal experiments, HUCBC improved outcomes after hypoxic-ischemic (HI) injury. Clinical trials using are underway, testing feasibility, safety efficacy for neonatal injury as well CP. We tested in validated rabbit model of CP acute changes secondary HI...
<h3>Importance</h3> Both preterm birth and increased screen time are known to be associated with an increase in risk of developmental behavioral sequelae. The association between high or a television computer the bedroom early school age adverse cognitive, executive function, language, behavior outcomes extremely children (EPT) is not well understood. <h3>Objective</h3> To assess cognition, EPT aged 6 7 years; second objective was examine rates structured physical activity weight....
Importance When preterm delivery is imminent, it remains unclear whether the timing from administration of antenatal betamethasone to birth may reduce mortality and morbidity among extremely infants. Objective To evaluate association duration exposure first dose with outcomes Design, Setting, Participants This cohort study enrolled infants born at 22 0/7 27 6/7 weeks’ gestation January 2016 February 2021 National Institute Child Health Human Development Neonatal Research Network centers....
Pediatric residency training programs are graduating residents who not competent in neonatal intubation, a vital skill needed for any pediatrician involved delivery room resuscitations. However, precise definition of competency during is lacking. The objective this study was to more precisely define the trajectory toward intubation pediatric residents, as framework later evaluating complementary tools.This retrospective single-center observational resident-performed intubations at Duke...
Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce. To determine whether electrographic more likely occur compared the preceding period they abnormal asphyxiated neonates receiving therapy. This prespecified nested cohort study of infants enrolled Optimizing Cooling (OC) multicenter Eunice Kennedy Shriver National Institute Child Health Human...
Decreases below the target temperature were noted among neonates undergoing cooling in Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Trial whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.To examine profile impact on outcome ≥ 36 wk gestation randomized at ≤ 6 hrs age targeting an esophageal 33.5°C 72 hrs.Infants with intermittent temperatures recorded <32.0°C during induction maintenance compared to all other...
In experimental animals neurologic damage may occur during seizure activity whether the is accompanied by motor and hypoxemia or animal paralyzed normoxemic. These findings suggest that it be important to detect in neonate. Nine infants who were mechanically ventilated with pancuronium had their condition diagnosed as activity. Vital signs continuously monitored six either oxygen saturation transcutaneous measured For group a whole, rhythmic fluctuations vital signs, cardiac rhythm,...