A5034961746- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Asthma and respiratory diseases
- Infant Development and Preterm Care
- Neuropeptides and Animal Physiology
- Neonatal and fetal brain pathology
- Inhalation and Respiratory Drug Delivery
- Neuroscience of respiration and sleep
- Breastfeeding Practices and Influences
- Nicotinic Acetylcholine Receptors Study
- Airway Management and Intubation Techniques
- Receptor Mechanisms and Signaling
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Congenital Diaphragmatic Hernia Studies
- Child Nutrition and Feeding Issues
- Olfactory and Sensory Function Studies
- Neonatal and Maternal Infections
- Emergency and Acute Care Studies
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Non-Invasive Vital Sign Monitoring
- Sepsis Diagnosis and Treatment
- Simulation-Based Education in Healthcare
- Neuroscience and Neural Engineering
Duke Medical Center
1996-2024
Duke University Hospital
1990-2024
Duke University
1997-2022
Pediatrics and Genetics
2021
March of Dimes
2017
Perinatal Institute
2001-2017
Robert Wood Johnson Foundation
2017
University of South Carolina
2017
Moberg Research (United States)
2016
Marymount University
2012
Objective Develop an online estimator that accurately predicts bronchopulmonary dysplasia (BPD) severity or death using readily-available demographic and clinical data. Design Retrospective analysis of data entered into a prospective registry. Setting Infants cared for at centres the United States Neonatal Research Network between 2011 2017. Patients 501–1250 g birth weight 23 0/7–28 6/7 weeks’ gestation. Interventions None. Main outcome measures Separate multinomial regression models...
The contractile effects of substance P (SP) were studied in isolated rabbit tracheal smooth muscle (TSM) segments vitro. Noncumulative administration SP produced dose-dependent increases TSM tension. mean (+/- SE) peak isometric tension (Tmax) with was 35.7 6.2%) the corresponding Tmax response to methacholine. dose agonist producing 50% (ED50) significantly lower for SP, averaging 1.8 0.4) X 10(-7) M, vs. 1.7 0.32) 10(-6) M Blockade both parasympathetic ganglia hexamethonium (10(-4) M) and...
Inflammation may contribute to lung injury and impaired alveolar development in bronchopulmonary dysplasia. We treated hyperoxia-exposed newborn rats with antibodies the neutrophil chemokine cytokine-induced chemoattractant-1 (CINC-1) during 95% O 2 exposure reduce adverse effects of hyperoxia-induced inflammation on development. Rats were exposed at birth air, , or + anti-CINC-1 (injected days 3 4). Bromodeoxyuridine (BrdU) was injected 6 h before death. Anti-CINC-1 treatment improved...
The neuromodulatory action of substance P (SP) was investigated in isolated rabbit tracheal smooth muscle (TSM) segments contracted with electrical field stimulation (ES). tissues were placed organ baths containing modified Krebs-Ringer solution and stimulated at a constant voltage (8 V; 24.5 mA) pulse duration (2 ms) ES frequencies ranging from 1 to 100 Hz. In the presence SP, there occurred dose-dependent augmentation TSM contractile response any given ES, maximal effect SP obtained dose...
Healthcare is increasingly dependent upon information technology (IT), but the accumulation of data has outpaced our capacity to use it improve operating efficiency, clinical quality, and financial effectiveness. Moreover, hospitals have lagged in adopting thoughtful analytic approaches that would allow operational leaders providers capitalize existing stores. In this manuscript, we propose a fundamental re-evaluation strategic IT investments healthcare, with goal increasing reducing costs,...
Pediatric residency training programs are graduating residents who not competent in neonatal intubation, a vital skill needed for any pediatrician involved delivery room resuscitations. However, precise definition of competency during is lacking. The objective this study was to more precisely define the trajectory toward intubation pediatric residents, as framework later evaluating complementary tools.This retrospective single-center observational resident-performed intubations at Duke...
The maturational effects of substance P (SP) on airway function were quantitatively assessed in 30 anesthetized tracheotomized rabbits ranging age from 2 to 29 days. Following paralysis, during mechanical ventilation with 100% O2 a body plethysmograph, respiratory resistance (Rrs) and dynamic compliance (Cdyn) continuously monitored. Noncumulative systemic infusions SP (0.001–5.0 micrograms/g) produced dose-dependent decreases pulmonary conductance (Grs), i.e., 1/Rrs, Cdyn. dose producing...
BACKGROUND: For novice providers, achieving competency in neonatal intubation is becoming increasingly difficult, possibly because of fewer opportunities. In the present study, we compared outcomes on manikins using direct laryngoscopy (DL), indirect video (IVL) a modified disposable blade, and augmented reality–assisted (ARVL), novel technique smart glasses to project magnified airway into intubator’s visual field. METHODS: Neonatal intensive care nurses (n = 45) with minimal simulated...
Absorption of the 1.34 μm Nd: YAG laser radiation in whole human blood and animal tissues is compared with 1.06, argon radiation. coefficients are determined biomedical utility wavelength evaluated.
We demonstrate how to develop a simulation tool help healthcare managers and administrators predict plan for staffing needs in hospital neonatal intensive care unit using administrative data. developed discrete event model of nursing staff needed then validated the against historical The process flow was translated into model. Results demonstrated that can be used give respectable estimate annual admissions, transfers, deaths based upon two different levels. provide with (1) valid method...
The maturation of the neuromodulatory action substance P (SP) was investigated in tracheal smooth muscle (TSM) segments isolated from rabbits aged 2-24 wk. tissues were placed baths containing Krebs-Ringer solution and contracted with electrical field stimulation (ES) ES frequencies ranging 1 to 75 Hz. In greater than mo age, frequency-response relationships progressively shifted presence a maximally effective SP dose (10(-7) M) such that by 24 wk age mean (+/- SEM) maximal tension (Tmax)...
Respiratory syncytial virus (RSV) is the leading viral cause of death in infants younger than 1 year. In July 2014, American Academy Pediatrics (AAP) Committee on Infectious Diseases concluded that "limited clinical benefit" for born at more 29 weeks' gestation, together with associated high cost immunoprophylaxis, no longer supported routine use palivizumab (Synagis).To evaluate impact newly adopted AAP prophylaxis administration health and subsequent hospital costs between less 32...
The vasoactive properties of substance P (SP) were studied in isolated rabbit pulmonary artery (PA) segments vitro. In the absence active base-line tone, noncumulative administration SP (10(-11) to 10(-4) M) produced dose-dependent increases PA tension. peak isometric tension (Tmax) with was similar Tmax response epinephrine; however, doses agonist producing a threshold contraction and 25% (ED25) significantly lower for SP. presence induced by epinephrine or 5-hydroxytryptamine, transient...
To elucidate the mechanism underlying temperature-induced changes in airway cholinergic contractility, effects of organ bath cooling were evaluated isolated rabbit smooth muscle (ASM) segments isometrically contracted with methacholine (METH) (10(-8)-10(-3) M) and electrical field stimulation (ES), wherein ES stimulus frequency was varied between 1 100 Hz. Cooling from 37 to 25 degrees C produced systematic increases (P less than 0.01) isometric tension at various administered doses METH...
After surveillance surveys documented the absence of methicillin-resistant Staphylococcus aureus (MRSA) in our intensive care nursery, an outbreak MRSA infection occurred there during a 7-month period 2005.Control measures included reinforcement hand hygiene and contact precautions procedures. Active cultures were obtained on all neonates, including interinstitutional transfers. A cohort unit was dedicated exclusively for neonates with MRSA. Pulsed-field gel electrophoresis performed...
Although many therapeutic interventions are necessary for the survival of preterm infant, understanding potential effects these treatments is important to decrease rate necrotizing enterocolitis (NEC) in infants.The aim this study was examine relationship between infant administered prior development NEC, specifically number packed red blood cell (PRBC) transfusions, weeks antibiotic therapy nosocomial infection, and mechanical ventilation days, NEC infants.A retrospective cohort controlled...
The rate of methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing in neonatal intensive care units. We determined the economic impact isolating and cohorting MRSA-colonized neonates on total hospital cost at a 49-bed, level III-IV unit.