C. Michael Cotten
A5063534302- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Retinopathy of Prematurity Studies
- Neonatal Health and Biochemistry
- Congenital Heart Disease Studies
- Birth, Development, and Health
- Respiratory Support and Mechanisms
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Preterm Birth and Chorioamnionitis
- Anesthesia and Neurotoxicity Research
- Antibiotics Pharmacokinetics and Efficacy
- Breastfeeding Practices and Influences
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Metabolism and Genetic Disorders
- Bacterial Infections and Vaccines
- Cardiovascular Conditions and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Pain Management Techniques
Duke University
2016-2025
Duke Medical Center
2014-2025
Clinical Research Institute
2016-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2009-2025
Duke University Hospital
2014-2025
Research Network (United States)
2009-2025
Health and Human Development (2HD) Research Network
2014-2025
Clinical Trial Investigators
2024
Walden University
2023
Duke Regional Hospital
2017-2022
Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia term infants with encephalopathy uncertain. We conducted a randomized trial gestational age at least 36 weeks who were admitted to hospital or before six hours either severe acidosis perinatal complications resuscitation birth had moderate encephalopathy. Infants randomly assigned usual care (control group) whole-body cooling an esophageal temperature 33.5...
<h3>Importance</h3> Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. <h3>Objective</h3> To review 20-year trends in maternal/neonatal care, complications, mortality among extremely born at Neonatal Research Network centers. <h3>Design, Setting, Participants</h3> Prospective registry of 34 636 infants, 22 28 weeks' gestation, birth weight 401 1500 g, 26 network centers between 1993 2012. <h3>Exposures</h3> birth. <h3>Main Outcomes Measures</h3>...
Our objectives were to identify factors associated with the duration of first antibiotic course initiated in 3 postnatal days and assess associations between initial subsequent necrotizing enterocolitis or death extremely low birth weight infants sterile culture results.We conducted a retrospective cohort analysis admitted tertiary centers 1998-2001. We defined empirical treatment as continuous therapy started results. used descriptive statistics characterize center practice, bivariate...
There are limited data to inform the choice between early treatment with continuous positive airway pressure (CPAP) and surfactant as initial support for extremely-low-birth-weight infants.
Between-hospital variation in outcomes among extremely preterm infants is largely unexplained and may reflect differences hospital practices regarding the initiation of active lifesaving treatment as compared with comfort care after birth. We studied born between April 2006 March 2011 at 24 hospitals included Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. Data were collected for 4987 before 27 weeks gestation without congenital anomalies....
Data reported during the past 5 years indicate that rates of survival have increased among infants born at borderline viability, but less is known about how these relate to early childhood neurodevelopmental outcomes. We compared and outcomes 22 24 weeks gestation, as assessed 18 months corrected age, across three consecutive birth-year epochs (2000-2003 [epoch 1], 2004-2007 2], 2008-2011 3]). The were 11 centers participated in National Institute Child Health Human Development Neonatal...
Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately neonatal mortality and childhood morbidity. To review survival, in-hospital morbidities, care practices, neurodevelopmental functional outcomes at 22-26 months' corrected age for infants. Prospective registry born 19 US academic centers that are part of the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. The study included 10 877...
OBJECTIVE. We sought to determine if an association exists between the use of histamine-2 receptor (H2) blockers and incidence necrotizing enterocolitis (NEC) in infants 401 1500 g birth weight. STUDY DESIGN. Data from National Institute Child Health Human Development Neonatal Research Network very low weight (401–1500 g) registry September 1998 December 2001 were analyzed. The relation diagnosis NEC (Bell stage II or greater) antecedent H2-blocker treatment was determined by using...
Benefits of identifying risk factors for bronchopulmonary dysplasia in extremely premature infants include providing prognostic information, likely to benefit from preventive strategies, and stratifying clinical trial enrollment.To identify dysplasia, the competing outcome death, by postnatal day; which improve prediction; develop a Web-based estimator using readily available information predict or death.We assessed 23-30 weeks' gestation born 17 centers Eunice Kennedy Shriver National...
BACKGROUND. Meningitis is a substantial cause of morbidity and mortality in neonates. Clinicians frequently use the presence positive blood cultures to determine whether neonates should undergo lumbar puncture. Abnormal cerebrospinal fluid (CSF) parameters are often used predict neonatal meningitis length type antibiotic therapy with culture negative CSF culture. METHODS. We evaluated first puncture 9111 at ≥34 weeks' estimated gestational age from 150 NICUs, managed by Pediatrix Medical...
OBJECTIVES. Previous studies have shown that incidence of invasive candidiasis varies substantially among centers, and previous use broad-spectrum antibiotics is a risk factor for in extremely low birth-weight infants. Differences center practices, such as antibiotic strategies the effects these on candidiasis, are not reflected assessments an individual's candidiasis. We evaluated relationship between empirical practices infants METHODS. studied cohort who survived ≥72 hours were admitted...
Background: Preterm birth is increasing worldwide, and late preterm births, which comprise more than 70% of all account for much the increase. Early onset sepsis results in significant mortality extremely infants, but little known about outcomes infants. Methods: This an observational cohort study infants <121 days age (119,130 less or equal to 3 life 106,142 between 4 120 life) with estimated gestational at 34 36 weeks, admitted 248 neonatal intensive care units United States 1996 2007....
<h3>Importance</h3> Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy 36 weeks' later gestation. To our knowledge, hypothermia trials have not been performed in presenting hours. <h3>Objective</h3> estimate the probability that to 24 risk of 18 months among encephalopathy. <h3>Design, Setting, and Participants</h3> A randomized clinical trial was conducted between April 2008 June 2016 gestation moderate severe...
Early-onset sepsis (EOS) remains a potentially fatal newborn condition. Ongoing surveillance is critical to optimize prevention and treatment strategies. To describe the current incidence, microbiology, morbidity, mortality of EOS among cohort term preterm infants. This prospective study included infants born at gestational age (GA) least 22 weeks birth weight greater than 400 g from 18 centers Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network...
Hypothermia for 72 hours at 33.5°C neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high. To determine if cooling 120 a temperature of 32.0°C disability age 18 months in infants with encephalopathy. Randomized 2 × factorial clinical trial neonates (≥36 weeks' gestation) US centers the Eunice Kennedy Shriver National Institute Child Health and Human Development Neonatal Research Network between October 2010 January 2016. A total 364 were randomly...
Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia. We performed an open, multicenter trial in which a birth weight 1000 g or less and gestational age between 22 weeks 0 days 28 6 were randomly assigned within 48 hours after delivery to receive at lower until 36 postmenstrual discharge, whichever occurred first. The primary outcome was composite death neurodevelopmental...
Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment the second postnatal week can improve survival without bronchopulmonary and adverse neurodevelopmental effects unknown. We conducted trial involving infants who had gestational age of less than 30 weeks been intubated for at least 7 days 14 28 days. Infants were randomly assigned receive either (4 mg...
Importance Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared formula. For receiving no or minimal maternal milk, it is unknown whether donor human conveys similar advantages vs Objective To determine if nutrient-fortified, pasteurized improves at 22 to 26 months’ corrected age infant formula among who received milk. Design, Setting, and Participants Double-blind, randomized clinical trial...
To compare incidence of late-onset sepsis (LOS) among extremely preterm infants before and during the COVID-19 pandemic. Multicenter cohort study with birthweight 401 to 1000 g or gestational age 22 28 weeks. LOS was defined as a bacterial fungal pathogen isolated from blood cerebrospinal fluid culture obtained after 72 hours age. Primary outcome calculated proportion (LOS cases all admissions) rate events/1000 patient days). A multivariable Poisson regression model used adjusted risk...
It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g less).
To describe age-related considerations and methods to improve hand-held spectral domain optical coherence tomography (HH-SD OCT) imaging of eyes neonates, infants, children.