A5070199600- Infant Nutrition and Health
- Primary Care and Health Outcomes
- Breastfeeding Practices and Influences
- Healthcare Policy and Management
- Hormonal and reproductive studies
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
- Clinical Nutrition and Gastroenterology
- Patient Satisfaction in Healthcare
- Chronic Disease Management Strategies
- Platelet Disorders and Treatments
- Health Policy Implementation Science
- Hemophilia Treatment and Research
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Thyroid Disorders and Treatments
- Mental Health Treatment and Access
- Gut microbiota and health
- Smoking Behavior and Cessation
- Venous Thromboembolism Diagnosis and Management
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Child Nutrition and Water Access
- Diet and metabolism studies
- Health Promotion and Cardiovascular Prevention
VA Greater Los Angeles Healthcare System
2014-2024
Health Services Research & Development
1996-2024
University of California, Los Angeles
2013-2024
Texas Tech University
2024
Charles R. Drew University of Medicine and Science
2011-2024
UCLA Health
2000-2024
Center for the Study of Healthcare Provider Behavior
2006-2024
University Medical Center of El Paso
2024
Norfolk and Norwich University Hospitals NHS Foundation Trust
2024
Medizinisches Laserzentrum Lübeck (Germany)
2005-2023
2][3] Health outcome measures, although a direct assessment of health status, also reflect spectrum confounding events such as comorbidities and the socioeconomic determinants health-factors that are generally beyond control physician's daily practice.As result, process measures quality increasingly being used. 4,5If linkages between provision care better status have been firmly established, there substantiated benefits to measuring over outcomes. 6Processes can be measured more frequently...
Objective: To study the systemic release and kinetics of high mobility group box-1 protein (HMGB1) in relation to clinical features a population patients with severe sepsis or septic shock compare these cytokines interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-α. Design: Prospective two cohorts patients. Setting: Intensive care unit infectious disease clinic at Karolinska University Hospital Huddinge. Patients: Twenty-six sepsis, 33 shock, reference five sepsis....
The aim of this study was to compare outcomes infants pre and post initiation a feeding protocol providing an exclusive human milk-based diet (HUM).
OBJECTIVES: To develop and test a standardized instrument, the purpose of which is to assess (1) whether skilled nursing facilities (SNFs) transfer residents emergency departments (ED) inappropriately, (2) are admitted hospitals (3) factors associated with inappropriate transfers. DESIGN: A structured implicit review (SIR) medical records. SETTING AND PARTICIPANTS: Using nested random sampling in eight community SNFs, we identified SNF hospital records 100 unscheduled transfers one 10...
In this study, we determined the effects of graded doses testosterone on muscle fiber cross-sectional area (CSA) and satellite cell number replication in older men.Healthy men, 60-75 yr old, received a long-acting GnRH agonist to suppress endogenous production 25, 50, 125, 300, or 600 mg enanthate im weekly for 20 wk.Immunohistochemistry, light confocal microscopy, electron microscopy were used perform typing quantitate myonuclear vastus lateralis biopsies, obtained before after wk...
Testosterone supplementation in men increases fat-free mass, but whether measures of muscle performance, such as maximal voluntary strength, power, fatigability, or specific tension, are improved has not been determined. Furthermore, the extent to which these performance related testosterone dose circulating concentration is unknown. To examine relationship between and 61 healthy, eugonadal young (aged 18-35 yr) were randomized 1 5 groups, each receiving a long-acting GnRH agonist suppress...
Patients with psychiatric disorders, particularly those severe mental illnesses, have high rates of undetected and untreated medical problems substantially elevated mortality due to illness. The authors sought develop a better understanding the demographic, medical, characteristics this population inform efforts improve care these persons.Using Department Veterans Affairs (VA) databases, examined use services by 175,653 patients who were treated in Southern California Nevada during fiscal...
Long-term euglycemia by intraperitoneal transplantation of microencapsulated islets has not been described in the diabetic large animal model. In this study, we report successful long-term reversal diabetes method spontaneous dogs. We have identified fundamental mechanism (s) associated with alginate-based microcapsule fibrosis, and devised methods to ameliorate problem. These include use purified alginate low mannuronic acid content cytokine suppression. Ten insulin-dependent, dogs (insulin...
OBJECTIVE Low vitamin D levels predict the development of diabetes. This double-blind, randomized, control study in subjects with prediabetes and hypovitaminosis evaluated whether high doses for 1 year affected insulin secretion, sensitivity, RESEARCH DESIGN AND METHODS A total 1,551 ≥40 years age not known to have diabetes were screened A1C levels. Subjects 5.8–6.9% underwent an oral glucose tolerance test (OGTT). 25-OH (25-OHD) <30 ng/mL randomized receive weekly placebo (n = 53) or...
Background: Provision of human milk has important implications for the health and outcomes extremely preterm (EP) infants. This study evaluated effects an exclusive diet on EP infants during their stay in neonatal intensive care unit. Subjects Methods: <1,250 g birth weight received a consisting either fortified with protein-based fortifier (HM) (n=167) or containing variable amounts cow milk-based protein (CM) (n=93). Principal were mortality, necrotizing enterocolitis (NEC), growth,...
Gene transfer has rarely been tested in randomized clinical trials.
As part of a prospective acellular pertussis (ACP) vaccine efficacy trial, 5 serum samples were obtained, over an 18-month period, from 101 ACP-vaccine recipients and 99 control subjects, to assess ACP antibody response decay. Immunoglobulin (Ig) G IgA antibodies toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae 2/3 (FIM) measured by enzyme-linked immunosorbant assay, titers agglutinin determined. Of the 16%–19% had preimmunization values PT that above assay's limit...
Original Article from The New England Journal of Medicine — Prophylactic Intravenous Administration Standard Immune Globulin as Compared with Core-Lipopolysaccharide in Patients at High Risk Postsurgical Infection
Resistin induces insulin resistance in mice. In humans, recent data suggest that resistin functions as a proinflammatory cytokine. Here, we studied up to 2 wks after admission patients with septic shock and/or severe sepsis.Two prospective studies of sepsis and vitro interaction monocytes.Intensive care unit at Karolinska University Hospital Center for Infectious Medicine, Institute, Huddinge, Sweden.Twenty-nine 66 shock.None.Ninety-five were studied, 25 whom died within 28 days. cytokine...
Infants who survive advanced necrotizing enterocolitis (NEC) at the time of birth are increased risk having poor long term physiological and neurodevelopmental growth. The economic implications morbidity in these children have not been studied to date. This paper compares healthcare costs beyond initial hospitalization period incurred by medical surgical NEC survivors with that matched controls without a diagnosis during hospitalization.The longitudinal utilization claim files infants born...
Study objectiveWe evaluated thromboembolic events after vitamin K antagonist reversal in post hoc analyses of pooled data from 2 randomized trials comparing 4-factor prothrombin complex concentrate (4F-PCC) (Beriplex/Kcentra) with plasma.MethodsUnblinded investigators identified events, using standardized terms (such as "myocardial infarction," "deep vein thrombosis," "pulmonary embolism," and "ischemic stroke"). A blinded safety adjudication board reviewed serious well those referred by an...