A5073279904- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Cancer Risks and Factors
- Frailty in Older Adults
- Clinical practice guidelines implementation
- Esophageal and GI Pathology
- Advanced Breast Cancer Therapies
- Medication Adherence and Compliance
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Advances in Oncology and Radiotherapy
Maimonides Medical Center
2025
National Cancer Registration Service
2018-2024
NHS England
2022-2024
National Health Service
2023
NHS Digital
2022-2023
Public Health England
2014-2023
Philips (United Kingdom)
2016-2023
Heart of England NHS Foundation Trust
2023
University of Massachusetts Chan Medical School
2022
University of Oxford
2018
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) DCIS patients develop subsequent invasive disease. A fundamental biologic question whether disease arises from tumor cells initial or represents new unrelated To address this question, we performed genomic analyses on lesion and paired recurrent tumors 95 together with single-cell DNA sequencing subset cases. Our data show that 75% cases recurrence was...
To examine the association between size and margin status of ductal carcinoma in situ (DCIS) risk developing ipsilateral invasive breast cancer DCIS after treatment, stage subtype cancer.Multinational, pooled cohort study.Four large international cohorts.Patient level data on 47 695 women with a diagnosis pure, primary 1999 2017 Netherlands, UK, US who underwent surgery, either conserving or mastectomy, often followed by radiotherapy endocrine both.The main outcomes were 10 year cumulative...
Abstract Background The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. Methods This was a national, prospective cohort study of DCIS diagnosed during 2003–2012. Results Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion disease increased (from 60 to 65%), low-grade decreased 10 6%) mean size 21.4 24.1 mm). Mastectomy more common for (36%) than (15%). Few (6%) patients treated...
Background and aimThe natural history of ductal carcinoma in situ (DCIS) is poorly understood. The aim this cohort study was to determine the outcomes women who had no surgery for screen-detected DCIS 6 months following diagnosis.MethodsEnglish breast screening databases were retrospectively searched diagnosed with without invasive cancer at record within diagnosis. These cross-referenced registry data. Details potentially eligible sent relevant units verification completion data forms...
The incidence of ductal carcinoma in situ (DCIS) rose rapidly when the NHS Breast Screening Programme (NHSBSP) started 1988. Some authorities consider that this represents both over-diagnosis and over-treatment. We report long-term follow-up DCIS diagnosed first 10 years (April 1988 to March 1999) West Midlands NHSBSP. 840 noninvasive breast cancers were recorded on national screening computer system. Following exclusions, thorough case note pathology review, 700 cases identified for...
Objectives Studies that use national datasets to evaluate the management of older women with breast cancer are often constrained by a lack information on patient fitness. This study constructed frailty index for secondary care administrative records and evaluated its ability improve models treatment patterns overall survival in cancer. Design Retrospective cohort study. Participants Women aged ≥50 years oestrogen receptor (ER) positive early invasive diagnosed between 2014 2017 England....
Abstract Objective To explore how the number and type of breast cancers developed after screen detected atypia compare with anticipated 11.3 per 1000 women screened within one three year screening round in United Kingdom. Design Observational analysis Sloane prospective cohort England. Setting Atypia diagnoses through English NHS programme reported to study. This is linked Cancer Registry Mortality Birth Information System for information on subsequent cancer mortality. Participants 3238...
Objectives To investigate the radiological features, diagnosis and management of screen-detected lobular neoplasia (LN) breast. Materials methods 392 women with pure LN alone were identified within prospective UK cohort study non-invasive breast (the Sloane Project). Demography, features diagnostic therapeutic procedures analysed. Results Non-pleomorphic (369/392) was most frequently diagnosed among aged 50–54 in 53.5% at first screen. It occurred commonly on left (58.0%; p = 0.003), upper...
The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial.We analysed the outcomes patients with DCIS without microinvasion diagnosed between 2003 2012 within Sloane project.Microinvasion was recorded in 521 11,285 (4.6%), considerable variation reported incidence among screening units (0-25%). Microinvasion associated high-grade DCIS, larger size, comedo necrosis solid, cribriform architecture (all P < 0.001). more frequent who underwent mastectomy...
Use of radiotherapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) varies according to country, precedent and prejudice. Results from a preliminary analysis the data available within UK Sloane Project can be appreciated context uncertainty concerning selection adjuvant RT following BCS DCIS. There was marked geographical variation use United Kingdom. However, overall, patients with DCIS treated were significantly more likely have planned (and given) if they...
Suicide remains the 10th leading cause of death in United States. Many patients presenting to healthcare settings with suicide risk are not identified and their mitigated during routine care. Our aim is describe planned methodology for studying implementation Zero framework, a systems-based model designed improve detection treatment, within large system. We use stepped wedge design roll-out framework over 4 years total 39 clinical units, spanning emergency department, inpatient, outpatient...