A5012843588- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
- Testicular diseases and treatments
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Advanced Breast Cancer Therapies
- Ovarian cancer diagnosis and treatment
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
Oncode Institute
2015-2025
The Netherlands Cancer Institute
2016-2025
University Medical Center Groningen
1999-2023
University of Groningen
1999-2023
Dutch Cancer Society
2013-2022
Leiden University Medical Center
2014-2021
University Medical Center Utrecht
2011-2021
Radboud University Nijmegen
2008-2021
Catharina Ziekenhuis
2011-2021
Amsterdam UMC Location University of Amsterdam
2014-2021
Survivors of Hodgkin's lymphoma are at increased risk for treatment-related subsequent malignant neoplasms. The effect less toxic treatments, introduced in the late 1980s, on long-term a second cancer remains unknown.We enrolled 3905 persons Netherlands who had survived least 5 years after initiation treatment lymphoma. Patients received between 1965 and 2000, when they were 15 to 50 age. We compared among these patients with that was expected basis incidence general population....
Hodgkin lymphoma (HL) survivors are at increased risk of cardiovascular diseases. It is unclear, however, how long the persists and what factors for various diseases.To examine relative absolute excess up to 40 years since HL treatment compared with disease incidence in general population study treatment-related different diseases.This retrospective cohort included 2524 Dutch patients diagnosed as having younger than 51 (median age, 27.3 years) who had been treated from January 1, 1965,...
PURPOSE: To quantify the long-term risk of second primary cancers (SCs) in patients diagnosed with Hodgkin’s disease (HD) during adolescence or young adulthood. PATIENTS AND METHODS: The SCs was assessed 1,253 HD before age 40 years and treated two Dutch cancer centers between 1966 1986. median follow-up duration 14.1 years. RESULTS: In all, 137 developed SCs, compared 19.4 cases expected on basis incidence rates general population (relative [RR] = 7.0; 95% confidence interval, 5.9 to 8.3)....
Cardiovascular diseases are increasingly recognized as late effects of Hodgkin lymphoma (HL) treatment. The purpose this study was to identify the risk factors for coronary heart disease (CHD) and quantify radiation dose heart, chemotherapy, other cardiovascular factors.We conducted a nested case-control in cohort 2,617 5-year HL survivors, treated between 1965 1995. Cases were patients diagnosed with CHD their first event after HL. Detailed treatment information collected from medical...
Inadvertent enterotomy is a feared complication of adhesiotomy during abdominal reoperation. The nature and extent this adhesion-associated problem are unknown.The records all patients who underwent reoperation between July 1995 September 1997 were reviewed retrospectively for inadvertent enterotomy, risk factors analysed using univariate multivariate parameters, postoperative morbidity mortality rates assessed.Inadvertent occurred in 52 (19 per cent) 270 reoperations. Dividing adhesions the...
Background:Hodgkin lymphoma (HL) survivors are at increased risk for developing valvular heart disease (VHD). We evaluated the determinants of and radiation dose-response.
Female Hodgkin lymphoma (HL) survivors treated with chest radiotherapy (RT) at a young age have strongly increased risk of breast cancer (BC). Studies in childhood shown that doxorubicin exposure may also increase BC risk. Although is the cornerstone HL chemotherapy, association between and has not been examined adult ages.
Abstract BACKGROUND Consultant gynecologic oncologists from the regional Comprehensive Cancer Center assisted community gynecologists in surgical treatment of patients with ovarian carcinoma when they were invited. For this report, authors evaluated effects primary surgery by a oncologist on outcome. METHODS The hospital files 680 epithelial who diagnosed between 1994 and 1997 northern part Netherlands abstracted. Treatment results analyzed according to operating physician's education using...
To assess the risk of secondary nonbreast cancers (SNBCs) in a recently treated population-based cohort breast cancer patients focused on association with treatment and prognostic implications.In 58,068 Dutch diagnosed invasive between 1989 2003, SNBC was quantified using standardized incidence ratios (SIRs), cumulative incidence, Cox regression analysis, adjusted for competing risks.After median follow-up 5.4 years, 2,578 SNBCs had occurred. Compared female population at large, this cohort,...
Background Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and Typhimurium infection facilitates colon development in genetically predisposed mice. This epidemiological study examined whether severe infection, usually acquired from contaminated food, is associated with increased risk humans. Methods findings We performed a nationwide registry-based to assess after diagnosed infection. National...
Previous reports suggest that radiation therapy for breast cancer (BC) can cause ischemic heart disease, with the radiation-related risk increasing linearly mean whole dose (MWHD). This study aimed to validate these findings in younger BC patients and investigate additional factors myocardial infarction (MI).
Few studies have examined the impact of treatment-related morbidity on long-term, cause-specific mortality in Hodgkin lymphoma (HL) patients.This multicenter cohort included 4919 HL patients, treated before age 51 years between 1965 and 2000, with a median follow-up 20.2 years. Standardized ratios, absolute excess (AEM) per 10 000 person-years, cumulative by stage primary treatment, accounting for competing risks, were calculated.HL patients experienced 5.1-fold (AEM = 123 deaths...
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) DCIS patients develop subsequent invasive disease. A fundamental biologic question whether disease arises from tumor cells initial or represents new unrelated To address this question, we performed genomic analyses on lesion and paired recurrent tumors 95 together with single-cell DNA sequencing subset cases. Our data show that 75% cases recurrence was...
Purpose Microsatellite instability (MSI), TP53 mutation, and KRAS mutation status have been reported as prognostic factors in colon cancer. Most studies, however, included heterogeneous groups of patients with respect to cancer stage. We determined the relevance high-frequency MSI (MSI-H), mutations, mutations a well-defined group stage III (N = 391), randomly assigned for adjuvant treatment fluorouracil-based chemotherapy. Methods Three hundred ninety-one tumor specimens were available. was...
The neoplastic Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin's lymphoma (cHL) are derived from B cells. frequency of HLA class II downregulation and its effect on prognosis unknown.Immunohistochemistry results for were evaluated 292 primary cHL patients a population-based approach. Patients diagnosed between 1989 2000 the northern part Netherlands. Median age at diagnosis was 38 years (range, 8 to 88 years); 63% had Ann Arbor stage I or II, 24% III, 13% IV disease. follow-up 7.1...
The impact of age and adjuvant therapy on contralateral breast cancer (CBC) risk prognostic significance CBC were evaluated.In 45,229 surgically treated stage I-IIIA patients diagnosed in the Netherlands between 1989 2002 was quantified using standardised incidence ratios (SIRs), cumulative Cox regression analysis, adjusted for competing risks.Median follow-up 5.8 years, which 624 occurred <6 months after index (synchronous) 1,477 thereafter (metachronous). Older lobular histology associated...
Purpose In classical Hodgkin's lymphoma (cHL), the impact of tumor cell Epstein-Barr virus (EBV) status on clinical outcome is controversial. Patients and Methods We assessed failure-free survival (FFS) relative (RS) in 412 patients with cHL age-defined subgroups a population-based study northern Netherlands. Tumor EBV was positive 34%, median follow-up time 7.1 years. Patients' age at diagnosis 35 years (range, 7 to 91 years), 63% had Ann Arbor stage I or II, 24% III, 12% IV disease....
To assess the risk of second primary cancer (SPC) after [(125)I]iodine prostate brachytherapy compared with prostatectomy and general population.In a cohort consisting 1,888 patients who received monotherapy (n = 1,187; 63%) or 701; 37%), SPC incidences were retrieved by linkage Dutch Cancer Registry. Standardized incidence rates (SIRs) absolute excess risks (AERs) calculated for comparison.A total 223 diagnosed SPC, 136 (11%) 87 (12%) prostatectomy, median follow-up 7.5 years. The SIR all...
Purpose Recently, an increased risk of diabetes mellitus (DM) was observed after abdominal irradiation for childhood cancer. Because many Hodgkin lymphoma (HL) survivors have also been treated with infradiaphragmatic radiotherapy, we evaluated the association between HL treatment and DM risk. Patients Methods Our study cohort comprised 2,264 5-year survivors, diagnosed before age 51 years 1965 1995. Treatment follow-up information collected from medical records general practitioners....