Thompson Robinson
A5045343269- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Optical Imaging and Spectroscopy Techniques
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Global Cancer Incidence and Screening
- Cerebrospinal fluid and hydrocephalus
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Particle accelerators and beam dynamics
- Gyrotron and Vacuum Electronics Research
- Breast Cancer Treatment Studies
- Pregnancy and preeclampsia studies
University of Leicester
2016-2025
NIHR Leicester Biomedical Research Centre
2017-2025
British Heart Foundation
2017-2025
Glenfield Hospital
2016-2025
Samsung (United Kingdom)
2023-2024
The George Institute for Global Health
2013-2024
The University of Sydney
2013-2024
Society of British Neurological Surgeons
2024
Sichuan University
2016-2024
King's College London
2024
Whether rapid lowering of elevated blood pressure would improve the outcome in patients with intracerebral hemorrhage is not known.We randomly assigned 2839 who had a spontaneous within previous 6 hours and systolic to receive intensive treatment lower their (with target level <140 mm Hg 1 hour) or guideline-recommended <180 Hg) use agents physician's choosing. The primary was death major disability, which defined as score 3 on modified Rankin scale (in 0 indicates no symptoms, 5 severe...
National Clinical Guidelines for Stroke. Intercollegiate Working Party Stroke, Royal College of Physicians. (Pp 150; £15.95.) Lavenham Press, 2000. ISBN 1-86016-120-0.\***| Stroke is a common problem, being the third cause mortality in UK and leading adult disability with resultant significant cost burden to NHS social services. The guidelines highlight wide national variation implementation evidence based practice as seen Stroke Association's Survey Physicians …
BackgroundTranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed assess whether tranexamic reduces haematoma expansion improves outcome in adults with stroke intracerebral haemorrhage.MethodsWe did an international, randomised placebo-controlled trial haemorrhage from acute units at 124 hospital sites 12 countries. Participants were randomly assigned (1:1) receive 1 g intravenous bolus followed by 8 h infusion of or a matching placebo, within...
Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravenous alteplase may improve recovery along reduced risk intracerebral hemorrhage.Using 2-by-2 quasi-factorial open-label design, we randomly assigned 3310 patients who were eligible thrombolytic (median age, 67 years; 63% Asian) to low-dose (0.6 mg per kilogram body weight) or the standard (0.9 kilogram); underwent randomization within 4.5 hours after onset stroke. The primary objective was determine...
Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols early intensive lowering and management algorithms hyperglycaemia, pyrexia, abnormal anticoagulation, implemented in hospital setting, could improve outcomes patients with spontaneous
<h2>Summary</h2><h3>Background</h3> High blood pressure is common in acute stroke and a predictor of poor outcome; however, large trials lowering have given variable results, the management high ultra-acute remains unclear. We investigated whether transdermal glyceryl trinitrate (GTN; also known as nitroglycerin), nitric oxide donor, might improve outcome when administered very early after onset. <h3>Methods</h3> did multicentre, paramedic-delivered, ambulance-based, prospective, randomised,...
Anti-money laundering (AML) regulations play a critical role in safeguarding financial systems, but bear high costs for institutions and drive exclusion those on the socioeconomic international margins. The advent of cryptocurrency has introduced an intriguing paradox: pseudonymity allows criminals to hide plain sight, open data gives more power investigators enables crowdsourcing forensic analysis. Meanwhile advances learning algorithms show great promise AML toolkit. In this workshop...
BackgroundPatients with acute intracerebral hemorrhage who are receiving factor Xa inhibitors have a risk of hematoma expansion. The effect andexanet alfa, an agent that reverses the effects inhibitors, on volume expansion has not been well studied.MethodsWe randomly assigned, in 1:1 ratio, patients had taken within 15 hours before having to receive or usual care. primary end point was hemostatic efficacy, defined by 35% less at 12 after baseline, increase score National Institutes Health...
Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated stroke uncertain.
BACKGROUND: The frequency and prognostic significance of subacute neurological improvement (SNI) on 90-day outcomes after acute intracerebral hemorrhage are unknown. METHODS: Secondary analyses participant data from the INTERACT2 trial (second Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial). SNI included any, moderate, significant, substantial defined as ≥1, ≥2, ≥3, ≥4 points decrease, respectively, National Institutes Health Stroke Scale 24 hours to 7 days...
Background and Purpose— The baroreceptor reflex arc is important in the short-term regulation of cardiovascular system, small studies have reported impaired cardiac sensitivity (BRS) after acute stroke. However, prognostic significance BRS uncertain. Methods— One hundred twenty-four patients underwent simultaneous ECG noninvasive beat-to-beat blood pressure (BP) monitoring within 72 hours neuroradiologically confirmed ischemic Cardiac was assessed from combined α-index by means power...
Background. The consequences of diseases in later life have been judged predominantly through mortality, resulting an emphasis on the fatal rather than nonfatal disabling conditions. We use a longitudinal study with follow-up at 2, 6, and 10 years to assess impact different both total expectancy (TLE) disability-free (DFLE).