A5029557672- Acute Ischemic Stroke Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Retinal Diseases and Treatments
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Heart Rate Variability and Autonomic Control
- Glaucoma and retinal disorders
- Alzheimer's disease research and treatments
- Cardiovascular Function and Risk Factors
- Neurosurgical Procedures and Complications
- Nutrition and Health in Aging
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Venous Thromboembolism Diagnosis and Management
Kyushu University
2016-2025
Cohort (United Kingdom)
2016-2024
National Institutes for Quantum Science and Technology
2024
National Hospital Organization
2012-2023
Kanazawa University
2023
Iwate Medical University
2023
Ehime University
2023
Tohoku University
2023
Kumamoto University
2016-2023
Hirosaki University
2023
Whether rapid lowering of elevated blood pressure would improve the outcome in patients with intracerebral hemorrhage is not known.We randomly assigned 2839 who had a spontaneous within previous 6 hours and systolic to receive intensive treatment lower their (with target level <140 mm Hg 1 hour) or guideline-recommended <180 Hg) use agents physician's choosing. The primary was death major disability, which defined as score 3 on modified Rankin scale (in 0 indicates no symptoms, 5 severe...
We examined the association between diabetes-related factors and pathology of Alzheimer disease (AD) to evaluate how diabetes affects pathogenic process AD.This study included specimens from a series 135 autopsies residents town Hisayama in Fukuoka prefecture (74 men 61 women) performed 1998 2003, who underwent 75-g oral glucose tolerance test clinical examinations 1988. measured including fasting glucose, 2-hour post-load plasma insulin, homeostasis model assessment insulin resistance...
<h3>Objective:</h3> We investigated the association between glucose tolerance status defined by a 75-g oral test (OGTT) and development of dementia. <h3>Methods:</h3> A total 1,017 community-dwelling dementia-free subjects aged ≥60 years who underwent OGTT were followed up for 15 years. Outcome measure was clinically diagnosed <h3>Results:</h3> The age- sex-adjusted incidence all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD) significantly higher in with diabetes than those...
Background— Changes in lifestyle and advances medical technology during the past half century are likely to have affected incidence mortality of cardiovascular disease prevalence its risk factors Japan. Methods Results— We established 5 cohorts consisting residents aged ≥40 years a Japanese community, 1961 (n=1618), 1974 (n=2038), 1983 (n=2459), 1993 (n=1983), 2002 (n=3108), followed up each cohort for 7 years. The age-adjusted stroke decreased greatly, by 51% men 43% women, from 1960s...
To investigate secular trends in the prevalence, incidence, and survival rate of dementia a Japanese elderly population comprehensive manner.Five cross-sectional surveys were conducted among residents community, aged ≥65 years, 1985, 1992, 1998, 2005, 2012. We also established 2 cohorts consisting this age group without 1988 (n = 803) 2002 1,231), each was followed for 10 years.The age-standardized prevalence all-cause Alzheimer disease (AD) increased with time (for dementia: 6.8% 4.6% 5.3%...
The associations between blood pressure and dementia have been inconclusive. We followed up a total of 668 community-dwelling Japanese individuals without dementia, aged 65 to 79 years, for 17 years examined the late-life midlife hypertension with risk vascular Alzheimer disease using Cox proportional hazards model. During follow-up, 76 subjects experienced 123 developed disease. age- sex-adjusted incidence significantly increased elevated levels (normal: 2.3, prehypertension: 8.4, stage 1...
Although the relation between serum LDL cholesterol level and coronary heart disease (CHD) is well established, its with stroke subtypes less clear.A total of 2351 inhabitants age >or=40 years in a Japanese community were followed up for 19 years.During follow-up, 271 subjects developed 144 CHD. Whereas age- sex-adjusted incidences CHD significantly increased increasing levels (P trend <0.001), associations ischemic or hemorrhagic not significant. The atherothrombotic infarctions (ATIs)...
The purpose of this study was to investigate the effects high-sensitivity C-reactive protein (hs-CRP) on risks coronary heart disease (CHD) in a general population Japanese.The Hisayama is population-based prospective cohort study. A total 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, revascularization, and sudden cardiac death). median hs-CRP level 0.43 mg/L at baseline. During follow-up period, 129 events observed....
Background— Recent evidence suggests that visit-to-visit variability in systolic blood pressure (SBP) and maximum SBP are predictors of cardiovascular disease. However, it remains uncertain whether these parameters predict the risks macrovascular microvascular complications patients with type 2 diabetes mellitus. Methods Results— The Action Diabetes Vascular Disease: Preterax Diamicron Modified Release Controlled Evaluation (ADVANCE) was a factorial randomized controlled trial lowering...
<h3>Objectives:</h3> The impact of chronic kidney disease (CKD) on clinical outcomes after acute ischemic stroke is still not fully understood. aim the present study was to elucidate how CKD and its components, proteinuria low estimated glomerular filtration rate (eGFR), affect stroke. <h3>Methods:</h3> subjects consisted 3,778 patients with first-ever within 24 hours onset from Fukuoka Stroke Registry. defined as or eGFR (<60 mL/min/m<sup>2</sup>) both. were neurologic deterioration...
Background and Purpose— Diabetes mellitus is an established risk factor for stroke. However, it uncertain whether prestroke glycemic control (PSGC) status affects clinical outcomes of acute ischemic The aim this study was to elucidate the association between PSGC neurological or functional in patients with Methods— From Fukuoka Stroke Registry (FSR), a multicenter stroke registry Japan, 3627 first-ever within 24 hours after onset were included present analysis. categorized into 4 groups...
To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) a general Japanese population.Four cross-sectional examinations were conducted among residents community aged >or=65 1985, 1992, 1998 2005.The age- sex-adjusted all-cause significantly increased with time (6.0% 4.4% 5.3% 8.3% 2005; P for trend = 0.002). A similar was observed AD (1.1%, 1.3%, 2.3% 3.8% respectively; < 0.001), while VD other/unclassified showed J-shaped patterns (for VD: 2.3%,...
Objectives To clarify the effect of tooth loss on development all‐cause dementia and its subtypes in an elderly Japanese population. Design Prospective cohort study. Setting The Hisayama Study, Japan. Participants Community‐dwelling adults without aged 60 older (N = 1,566) were followed for 5 years (2007–2012). Measurements classified into four categories according to baseline number remaining teeth (≥20, 10–19, 1–9, 0). risk estimates dementia, Alzheimer's disease ( AD ), vascular (VaD)...
<h3>Objective:</h3> To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <h3>Methods:</h3> Associations ICH sites poor (death [6] or major disability [3–5] modified Rankin Scale) European Quality Life Scale (EQ-5D) utility scores at 90 days were assessed logistic regression models. <h3>Results:</h3> Of 2,066 patients included...
Several observational studies have reported that higher visit-to-visit blood pressure variability is a risk factor for cognitive impairment and dementia. However, no investigated the association of day-to-day assessed by home measurement with development dementia.A total 1674 community-dwelling Japanese elderly without dementia, ≥60 years age, were followed up 5 (2007-2012). Home was measured 3 times every morning median 28 days. Day-to-day systolic (SBP) diastolic variabilities, calculated...
To investigate whether higher intake of potassium, calcium, and magnesium reduces the risk incident dementia.Prospective cohort study.The Hisayama Study, in Japan.One thousand eighty-one community-dwelling Japanese individuals without dementia aged 60 older.A 70-item semiquantitative food frequency questionnaire was used to assess intakes. Hazard ratios (HRs) for development all-cause its subtypes were estimated using Cox proportional hazards model.During a 17-year follow-up, 303...
Objectives To determine the effect of milk and dairy intake on development all‐cause dementia its subtypes in an elderly J apanese population. Design Prospective cohort study. Setting The Hisayama Study, apan. Participants Individuals aged 60 older without (N = 1,081). Measurements Milk was estimated using a 70‐item semiquantitative food frequency questionnaire grouped into quartiles. risk estimates dementia, A lzheimer's disease ( AD ), vascular (VaD) were computed Cox proportional hazards...
The relationship between the poststroke blood pressure (BP) and functional outcomes in patients with acute ischemic stroke is still controversial. aim of present study was to elucidate impact BP on clinical stroke. Among Fukuoka Stroke Registry, 1874 first-ever (within 24 hours onset) who had been functionally independent before onset were prospectively enrolled study. levels defined as average values during 48 after onset. a good neurological recovery, deterioration, poor outcome. higher...
Vascular endothelial growth factor (VEGF) is a well-known molecule mediating neuronal survival and angiogenesis. However, its clinical significance in ischemic stroke still controversial. The goal of this study was to examine the temporal profile plasma VEGF value with taking subtypes into consideration. We prospectively enrolled 171 patients age- gender-matched healthy subjects. were divided 4 subtypes: atherothrombotic infarction (ATBI, n = 34), lacunar (LAC, 45), cardioembolic (CE, 49)...