A5086122414- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Chronic Disease Management Strategies
- Global Health Care Issues
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Education
- Neurosurgical Procedures and Complications
- Diabetes Management and Research
- Healthcare Systems and Reforms
- Gastric Cancer Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Cardiac pacing and defibrillation studies
- Health disparities and outcomes
- Biomedical Text Mining and Ontologies
- Heart Failure Treatment and Management
- Enhanced Recovery After Surgery
- Chronic Kidney Disease and Diabetes
- Endoplasmic Reticulum Stress and Disease
Chinese University of Hong Kong
2018-2025
Prince of Wales Hospital
2018-2025
St. Paul's Hospital
2021
Hong Kong Jockey Club
2018-2019
Hong Kong Academy of Medicine
2018
John Hunter Hospital
2015
University of Newcastle Australia
2015
The George Institute for Global Health
2015
Royal Prince Alfred Hospital
2015
The University of Sydney
2015
<h3>Objective:</h3> To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <h3>Methods:</h3> Associations ICH sites poor (death [6] or major disability [3–5] modified Rankin Scale) European Quality Life Scale (EQ-5D) utility scores at 90 days were assessed logistic regression models. <h3>Results:</h3> Of 2,066 patients included...
<h3>Objectives:</h3> To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved in patients with acute intracerebral hemorrhage (ICH). <h3>Methods:</h3> INTERACT2 was an open, blinded endpoint, randomized controlled trial 2,839 ICH within 6 hours onset elevated systolic (SBP) (150–220 mm Hg) who were allocated receive (target SBP <140 Hg 1 hour, lower limit 130 for treatment cessation) or guideline-recommended <180...
Geriatric syndromes, multimorbidity, and disability are prevalent among ageing population. However, no study empirically examined their additive or synergistic effect on healthcare use. The present aims to estimate overlapping prevalence of geriatric disability; examine associations these three conditions with A cross-sectional was conducted in community-dwelling older adults aged 60 above 12 Hong Kong districts. Pearson's chi-squared test for trend performed across age groups (60–69, 70–79,...
Abstract Background and Aims Several guidelines recommend screening for NAFLD in patients with type 2 diabetes (T2D). We aimed to determine if there is a threshold of age duration T2D liver‐related event development guide strategies. Approach Results conducted territory‐wide retrospective cohort study adult diagnosed between 2000 2014 Hong Kong allow at least 5 years follow‐up. The primary endpoint was events, defined as composite HCC cirrhotic complications. This included 7028 (mean age,...
BackgroundCurrent labelling advises discontinuation of metformin when estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 due to increased risk lactic acidosis. However, in real-world practice, the risk-benefit ratios remain uncertain. We examined associations discontinued-metformin use with cardiorenal and clinical outcomes patients type 2 diabetes (T2D) advanced chronic kidney disease.MethodsIn this territory-wide, retrospective cohort target trial emulation study, we included...
BACKGROUND: The frequency and prognostic significance of subacute neurological improvement (SNI) on 90-day outcomes after acute intracerebral hemorrhage are unknown. METHODS: Secondary analyses participant data from the INTERACT2 trial (second Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial). SNI included any, moderate, significant, substantial defined as ≥1, ≥2, ≥3, ≥4 points decrease, respectively, National Institutes Health Stroke Scale 24 hours to 7 days...
Abstract Background Advance care planning (ACP) facilitates identification and documentation of patients’ treatment preferences. Its goal aligns with that palliative – optimizing quality life seriously ill patients. However, concepts ACP remain poorly recognized in Chinese population. This study aims at exploring barriers to from perspective patients their family caregivers. Methods is a qualitative conducted Palliative Day Care Centre Hong Kong between October 2016 July 2017. We carried out...
Summary Background Early screening may prevent fibrosis progression in metabolic‐associated fatty liver disease (MAFLD). Aims We developed and validated MAFLD score (MFS) for identifying advanced (≥F3) among patients. Methods This cross‐sectional, multicentre study consecutively recruited patients receiving tertiary care (Malaysia as training cohort [ n = 276] Hong Kong Wenzhou validation 431]). Patients completed biopsy, vibration‐controlled transient elastography (VCTE), clinical...
Abstract Insulin has been discovered for more than a century; however, its benefits to people with diabetes are yet be fully realized due barriers related access, quality of care and costs. therapy remains the cornerstone management. The multicausality subtypes calls comprehensive phenotyping use biomarkers ensure timely insulin achieve early glycaemic control long‐term benefits. Biosimilar insulins biologic products that closely resemble originator without significant differences in safety...
Abstract This study aimed to (a) examine whether device-assessed moderate-to-vigorous physical activity (MVPA) was associated with suicidal ideation (SI) in adolescents attention-deficit/hyperactivity disorders (ADHD), (b) investigate the association mediated by depression, and (c) assess anxiety, stress, resilience would work depression constitute chain mediation paths between MVPA SI. Sixty ADHD aged 12–17 (Mage = 14.33 ± 1.43 years) met inclusion criteria. data were assessed using...
The kidney-brain interaction has been a topic of growing interest. Past studies the effect kidney function on intracerebral hemorrhage (ICH) outcomes have yielded inconsistent findings. Although second, main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2) suggests effectiveness early intensive blood pressure (BP) lowering improving functional recovery after ICH, balance potential benefits and harms this treatment those with decreased remains...
Objectives To evaluate the psychometric properties of Hong Kong version Neighbourhood Cohesion Instrument (HK-NCI) and examine whether neighbourhood social cohesion as measured using HK-NCI would be associated with evaluative, hedonic eudaemonic well-being. Design A validation analysis followed by a cross-sectional community-based survey. Setting Communities in two districts (Sha Tin Tai Po) Kong. Participants 301 community-dwelling Chinese men women aged 60 years older normally residing Sha...
According to the Quality of Death Index, Hong Kong is lagging behind many other Western and Asian countries in category palliative healthcare. To ensure provision high-quality care, it important explore self-competence health social care workers coping with death work including care. This region-wide study aims assess level a validated Self-Competence Work Scale (SC-DWS) examine its correlates.The SC-DWS was administered cross-sectional convenience sample across eight healthcare institutions...
Abstract Background: The incidence of esophageal adenocarcinoma was increasing in the Western Europe and United States, but not East Asian countries. Population based study on trend Hong Kong available. Materials Methods: Population-based data Cancer Registry from 1984 to 2003 were used. Cases grouped into four 5-year periods. Average age standardized rate (WSR) each period calculated by averaging WSR 5 years period, basing world standard population, with adjustment made for cases missing...
Abstract Aim Therapeutic inertia, hypoglycaemia and poor treatment persistence can lead to glycaemic fluctuation outcomes in type 2 diabetes (T2D). We compared glycated haemoglobin (HbA1c) variability, insulin initiation, severe clinical events patients with T2D initiated dipeptidyl peptidase‐4 inhibitors (DPP4is) at low versus high HbA1c thresholds. Methods Using territory‐wide electronic medical records Hong Kong, we curated a propensity score‐matched cohort of DPP4i <7.5% ≥7.5%...
Abstract Aims To explore the patterns of use oral glucose‐lowering drugs (OGLDs) in Asian patients with type 2 diabetes (T2D), focusing on sulphonylureas (SUs), and to describe patient profiles according treatment regimen. Methods We conducted a cross‐sectional analysis data from adults T2D 11 countries/regions structured assessment enrolled prospective Joint Asia Diabetes Evaluation (JADE) register between November 2007 December 2019. Patients receiving insulin and/or injectable...
To investigate the impact of a serious illness communication skills training course on medical students' attitudes regarding clinical empathy, self-efficacy in empathic communication, and learning different dimensions empathy.A mixed-methods design was used. A blended Serious Illness Communication Skills Training (SI-CST) delivered to sixth-year students. Students (n=185) completed questionnaires with 20-item Jefferson Scale Empathy (JSE) self-rated preparedness level for five tasks at...
Helicobacter pylori infection causes chronic gastric inflammation that contributes to various gastroduodenal diseases, including peptic ulcer and cancer. Despite broad regional variations, the prevalence of resistance antibiotics used manage H is increasing worldwide; this trend could hinder success eradication therapy. To increase awareness improve diagnosis treatment its in Hong Kong, our consensus panel proposed a set guidance statements for disease management. We conducted comprehensive...
Abstract Aims To examine whether early treatment intensification using dipeptidyl‐peptidase 4 inhibitors (DPP4i) delays insulin initiation in Chinese patients diagnosed with type 2 diabetes for less than 5 years. Materials and Methods In a territory‐wide prospective cohort study, initiating DPP4i at duration <2 years (early intensification) 3–5 (late were matched 1:1 propensity‐score matching ( n = 908 each arm). We used Cox regression to compare the risk of between two groups. explored...
Summary Background & Aims We aimed to determine the trends in risk factor control and treatment among patients with non‐alcoholic fatty liver disease (NAFLD) type 2 diabetes (T2D) 2000–2020. Methods conducted a territory‐wide cohort study of adult NAFLD T2D diagnosed between 1 January 2000 31 July 2021 Hong Kong. was defined by use any anti‐diabetic agents, laboratory tests and/or diagnosis codes. Results This included 16,084 (mean age, 54.8 ± 12.0 years; 7124 male [44.3%]). The...
Introduction: Under the current opt-in system, deceased organ donation rate remains low in Hong Kong.An opt-out system and an combined with allocation priority (ie, to donors as transplant recipients) have been proposed encourage willingness among general population towards donation.This study aimed compare willingness, its determinants, across these three legislative systems. Methods:A random telephone survey of Kong permanent residents aged ≥18 years was conducted between August October...
The Hong Kong government has launched the Elderly Health Care Voucher (EHCV) scheme to facilitate primary care in private sector for older adults. This study aimed examine whether voucher use was associated with a shift of healthcare burden from public sector, vaccine uptake and continuity care.This cross-sectional survey recruited adults ≥3 chronic diseases through convenience sampling seven general outpatient clinics, geriatric day hospitals, five specialist clinics Kong. We used multiple...