A5043447785- Diabetes Management and Education
- Chronic Disease Management Strategies
- Workplace Health and Well-being
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Employment and Welfare Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clinical practice guidelines implementation
- Palliative Care and End-of-Life Issues
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Occupational Health and Safety Research
- Musculoskeletal pain and rehabilitation
- Healthcare professionals’ stress and burnout
- Economic and Financial Impacts of Cancer
- Advanced Glycation End Products research
- Patient Dignity and Privacy
- Dementia and Cognitive Impairment Research
- Disaster Management and Resilience
- Cellular transport and secretion
- Public Health Policies and Education
- Organizational Leadership and Management Strategies
- Alzheimer's disease research and treatments
- Disaster Response and Management
- Bacterial biofilms and quorum sensing
Chinese University of Hong Kong
2023-2025
Prince of Wales Hospital
2023-2025
Asia Diabetes Foundation
2023-2025
Hong Kong Jockey Club
2023
University of Hong Kong
2018-2023
University of Oxford
2023
University of Illinois Urbana-Champaign
2011
Edith Cowan University
2009
University of South Carolina
1992
OBJECTIVE Patient-level simulation models, mainly developed in Western populations, capture complex interactions between risk factors and complications to predict the long-term effectiveness cost-effectiveness of novel treatments identify high-risk subgroups for personalized care. However, incidence outcomes varies significantly by ethnicity region. We used high-quality, patient-level register data develop Chinese Diabetes Outcomes Model (CDOM) predicting incident recurrent events type 2...
<p dir="ltr"><b><i>Objective</i></b></p><p dir="ltr">Patient-level simulation models, mainly developed in Western populations, capture complex interactions between risk factors and complications to predict the long-term effectiveness cost-effectiveness of novel treatments, while identify high-risk subgroups for personalized care. However, incidence outcomes varies significantly by ethnicity region. We used high-quality, patient-level register data...
<p dir="ltr"><b><i>Objective</i></b></p><p dir="ltr">Patient-level simulation models, mainly developed in Western populations, capture complex interactions between risk factors and complications to predict the long-term effectiveness cost-effectiveness of novel treatments, while identify high-risk subgroups for personalized care. However, incidence outcomes varies significantly by ethnicity region. We used high-quality, patient-level register data...
People with type 2 diabetes are increasingly susceptible to complications that not specific diabetes. We aimed examine the temporal trajectories of hospitalisations for traditional and non-traditional in people included 758,254 incident between 2002 2018 Hong Kong, followed up until 2019. 72 selected diseases all-cause deaths. derived based on pairs disease associations identified trajectory clusters using Markov Cluster Algorithm. During a median follow-up 7.8 (IQR: 4-12) years, 57.6%...
Presenteeism is the employee behaviour of physically attending work with reduced performance due to illness or for other reasons. Nurses are four times more likely exhibit presenteeism compared occupations, threatening patient safety through increased falls, medication errors and staff-to-patient disease transmission. There a paucity standardized instruments that quantify association between its exposures related productivity. This study aims validate an instrument comprehensively measures...
Despite optimized risk factor control, people with prior cardiovascular disease remain at high risk. We assess the immediate- and longer-term impacts of new vascular nonvascular events on quality life (QoL) hospital costs among participants in REVEAL (Randomized Evaluation Effects Anacetrapib Through Lipid Modification) trial secondary prevention.
Abstract Aim Therapeutic inertia, hypoglycaemia and poor treatment persistence can lead to glycaemic fluctuation outcomes in type 2 diabetes (T2D). We compared glycated haemoglobin (HbA1c) variability, insulin initiation, severe clinical events patients with T2D initiated dipeptidyl peptidase‐4 inhibitors (DPP4is) at low versus high HbA1c thresholds. Methods Using territory‐wide electronic medical records Hong Kong, we curated a propensity score‐matched cohort of DPP4i <7.5% ≥7.5%...
Leadership style and organizational culture have often been studied independently in nursing research despite abundant evidence that the two factors both influence employee outcomes. Moreover, diverse theoretical typology measuring instruments challenges generalizability of findings. Employees from different cultural, geographical, occupational settings were also reported to varying interpretation on leadership underlying constructs. This study aims validate Nursing Organizational Culture...
Background-The workload of public hospital staff is heightened during seasonal influenza surges in hospitals serving densely populated cities. Such work environments may subject to increased risk sickness presenteeism. Presenteeism detrimental nurses' health and lead downstream productivity loss, resulting financial costs for organizations. Aims-This study aims quantify how occupancy surge impacts presenteeism related high-intensity inpatient metropolitan hospitals. Methods-Full-time nurses...
Abstract Background Patients with type 2 diabetes (T2D) are at high risk of developing multiple complications, affecting their health‐related quality life (HRQoL). Existing studies only considered impact complication on HRQoL in the year occurrence but not its residual impacts subsequent years. We investigated temporal diabetes‐related complications a 12‐year prospective cohort ambulatory Chinese patients T2D enrolled clinic‐based Joint Asia Diabetes Evaluation (JADE) Register. Methods...
At a specific time in the Caulobacter crescentus cell cycle, single flagellar filament and multiple receptor sites for swarmer-specific phage phi Cbk are assembled at one pole of predivisional cell. One cluster genes required this morphogenesis, flaYG region, includes flgJKL genes, which encode structural proteins filament. These flagellin flanked by assembly, flaYE end flaF-flbT-flbA-flaG other. In study, we characterized mutants carrying large chromosomal deletions within region. Several...
Abstract Background Presenteeism among nurses is the common behaviour of being physically present at work when one should not be due to personal health and well-being, a stressful environment, lack work–life balance, or sense professional identity obligation. Aims To explore nurses’ decision-making process related presenteeism in large Hong Kong public hospital. Methods As part larger study on nurse Kong, we conducted focus groups with understand their considerations working sick. Results...
Living the final days of life being cared for at home is a preference expressed by many. The data on effectiveness home-based end-of-life care (EoLC) intervention to improve holistic conditions terminally ill patients are scanty. This study sought evaluate psychosocial EoLC in Hong Kong.A prospective cohort was conducted, applying Integrated Palliative Care Outcome Scale (IPOS) 3 timepoints (service intake, 1-month, and 3-months after enrollment). A total 485 eligible, consenting people...
Abstract The light chain of botulinum neurotoxin A (BoNT/A‐LC) is a Zn‐dependent protease that specifically cleaves SNAP25 the SNARE complex, thereby impairing vesicle fusion and neurotransmitter release at neuromuscular junctions. C‐terminus (residues 141–206) retains full activity for BoNT/A‐LC‐catalyzed cleavage P1‐P1' (Gln197‐Arg198). Using structure complex between BoNT/A‐LC as model to design SNAP25‐derived pseudosubstrate inhibitors (SNAPIs) prevent presentation scissile bond active...
Introduction: Rosuvastatin compared with atorvastatin has been associated worse renal outcomes in people diabetes and chronic kidney disease (CKD). There are interethnic differences statin metabolism dosage. We the risk associations of rosuvastatin cardiorenal Chinese across varying functions. Methods: conducted a population-based analysis 95,713 new users (n=83,962) (n=11,751) 2002-2019, followed up until December 31, 2019 Hong Kong Hospital Authority. used Cox-model time-dependent exposure...
N-terminal pro B-type natriuretic peptide (NT-proBNP) is a that strongly associated with congestive heart failure (CHF). The utility of NT-proBNP for prediction cardiovascular events and renal endpoints, compared clinical risk factors, has not been evaluated in detail. We hypothesise can improve stratification cardiorenal type 2 diabetes, beyond provided by factors.