A5020273125- Diabetes Treatment and Management
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trace Elements in Health
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Diabetes and associated disorders
- Chronic Disease Management Strategies
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Heavy metals in environment
- Climate Change and Health Impacts
- Diabetes Management and Education
- Assisted Reproductive Technology and Twin Pregnancy
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Frailty in Older Adults
- Telomeres, Telomerase, and Senescence
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Folate and B Vitamins Research
- Diet and metabolism studies
Chinese University of Hong Kong
2019-2025
Prince of Wales Hospital
2020-2025
Yunnan Provincial Hospital of Traditional Chinese Medicine
2024
Second Hospital of Hebei Medical University
2016-2024
Hebei Medical University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Chongqing University
2022-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
National Health and Family Planning Commission
2023
OBJECTIVE Several studies support associations between relative leukocyte telomere length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates the relationship rLTL risk glycemic progression in patients with RESEARCH DESIGN AND METHODS In this cohort study, consecutive Chinese diabetes (N = 5,506) from Hong Kong Diabetes Register stored baseline DNA available follow-up data were studied. was measured using quantitative PCR. Glycemic defined as new need for...
Although previous studies have examined the hepatotoxicity of single metal exposure, associations between mixture and non-alcoholic fatty liver disease (NAFLD) or fibrosis remain unclear. This study investigated urinary with risks NAFLD in US adults using data from National Health Nutrition Examination Survey (NHANES) 2017.01 to 2020.03. Vibration-controlled transient elastography was used detect controlled attenuation parameter (CAP) stiffness measurement (LSM), which are indicators...
Studies have established the short-term efficacy of nirmatrelvir-ritonavir in managing COVID-19, yet its effect on post-COVID-19 condition, especially patients admitted to hospital, remains understudied. This study aimed examine condition among hospital Hong Kong.
Background Clinical trials have demonstrated that remission of type 2 diabetes can be achieved following sustained weight loss. However, the feasibility achieving through management in real-world settings remains unclear. In this study, we aimed to examine association change at 1 year after diagnosis with long-term incidence and sustainability Hong Kong. Methods findings This was a population-based observational cohort study. The territory-wide Risk Assessment Management Programme for...
Some studies found out that TC/HDL-C ratio is a predictor of Cardiovascular disease (CVD) and Nonalcoholic fatty liver (NAFLD) related to CVD. And some researches have already studied Apolipoprotein B A1 (ApoB/ApoA1) Triglyceride High-density lipoprotein cholesterol (TG/HDL-C) were both with CVD NAFLD, but few the association between NAFLD. So, we suspected was also The research aims study predictive value NAFLD help early detection Based on Jinchang Cohort, contained 32,121 participants. We...
Long-term exposure to fine particulate matter (PM2.5) is associated with an increased risk of type 2 diabetes (T2D). However, limited data on trends in the global burden T2D attributed PM2.5, particularly different regions by social-economic levels. We evaluated spatio-temporal changes disease PM2.5 from 1990 2019 204 countries and socio-demographic indexes (SDI). This a retrospective analysis Global Burden Disease Study (GBD2019) database. The age-standardized mortality rate (ASMR)...
Exposure to ambient air pollution has been reported be inversely correlated with human reproductive health. However, the results of previous studies exploring association between and in vitro fertilization (IVF) outcomes are conflicting, further research is needed clarify this association. This study aimed investigate associations exposure pollutants IVF outcomes. We conducted a multicenter retrospective cohort involving 20,835 patients from four cities Northern China, contributing 11,787...
Background The prevalence of type 2 diabetes has increased in both young and old people. We examined age-specific associations population attributable fractions (PAFs) risk factors for all-cause cause-specific mortality people with diabetes. Methods findings analysed data from 360,202 Chinese who participated a territory-wide complication screening programme Hong Kong between January 2000 December 2019. compared the hazard ratios PAFs eight factors, including three major comorbidities...
BackgroundCurrent labelling advises discontinuation of metformin when estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 due to increased risk lactic acidosis. However, in real-world practice, the risk-benefit ratios remain uncertain. We examined associations discontinued-metformin use with cardiorenal and clinical outcomes patients type 2 diabetes (T2D) advanced chronic kidney disease.MethodsIn this territory-wide, retrospective cohort target trial emulation study, we included...
Background Older adults with diabetes are at high risk of severe hypoglycemia (SH). Many machine-learning (ML) models predict short-term not specific for older and show poor precision-recall. We aimed to develop a multidimensional, electronic health record (EHR)-based ML model one-year SH requiring hospitalization in diabetes. Methods findings adopted case-control design retrospective territory-wide cohort 1,456,618 records from 364,863 unique (age ≥65 years) least 1 Hong Kong Hospital...
Abstract Metals have been proved to be one of risk factors for chronic kidney disease (CKD) and diabetes, but the effect mixed metal co-exposure potential interaction between metals are still unclear. We assessed urine whole blood levels cadmium (Cd), manganese (Mn), lead (Pb), mercury (Hg), renal function in 3080 adults from National Health Nutrition Survey (NHANES) (2011–2018) explore exposure on CKD especially people with type 2 diabetes mellitus (T2DM). Weighted quantile sum regression...
Abstract Background To compare the expression levels of long non-coding RNA (lncRNA) and messenger (mRNA) in pre-receptive endometrium between patients with Polycystic Ovary Syndrome (PCOS)and normal ovulation undergoing vitro fertilization-embryo transfer (IVF-ET). Methods Endometrial tissues were collected endometrial vacuum curette phase (3 days after oocytes retrieval) from PCOS control groups. LncRNAs mRNAs identified via sequencing alignments. A subset 9 differentially expressed...
Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals that have been linked to increased risk of gestational diabetes mellitus (GDM) may affect glucose metabolisms during pregnancy. We examined the associations between maternal PFAS exposure GDM among 1601 mothers who joined Hyperglycaemia-and-Adverse-Pregnancy-Outcome (HAPO) Study in Hong Kong 2001–2006. All underwent a 75 g-oral-glucose-tolerance test at 24–32 weeks gestation. measured serum concentrations six biomarkers...
Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. We measured Cd concentrations in urine samples at or near 13, 24, and 35 gestational weeks from 282 women Wuhan, China. used generalized estimating equation models to assess associations between maternal creatinine adjusted urinary each trimester size. A significant inverse association was observed higher levels during 1st size girls. For log unit increase...
OBJECTIVE Several studies support potential links between relative leukocyte telomere length (rLTL), a biomarker of biological aging, and type 2 diabetes. This study investigates relationships rLTL incident cardiovascular disease (CVD) in patients with RESEARCH DESIGN AND METHODS Consecutive Chinese diabetes (N = 5,349) from the Hong Kong Diabetes Register for whom DNA obtained at baseline was stored follow-up data were available studied. measured by using quantitative PCR. CVD diagnosed on...
OBJECTIVE There has been a shift toward new classes of glucose-lowering drugs (GLDs) in the past decade but no improvements glycemic control or hospitalization rates due to severe hypoglycemia (SH) previous surveys. We examined trends GLDs use, control, and SH rate among patients with diabetes Hong Kong, which introduced territory-wide, team-based care model since 2000. RESEARCH DESIGN AND METHODS Using population-based data from Kong Diabetes Surveillance Database, we estimated age-...