A5083924386- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Trace Elements in Health
- Iron Metabolism and Disorders
- Genetic diversity and population structure
- MicroRNA in disease regulation
- melanin and skin pigmentation
- Effects and risks of endocrine disrupting chemicals
- Heavy metals in environment
- Genetic Mapping and Diversity in Plants and Animals
- Lung Cancer Treatments and Mutations
- Child Nutrition and Water Access
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Mercury impact and mitigation studies
- Tree-ring climate responses
- Folate and B Vitamins Research
- Aluminum toxicity and tolerance in plants and animals
- Peroxisome Proliferator-Activated Receptors
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Renal function and acid-base balance
- Genetic Associations and Epidemiology
- Intramuscular injections and effects
First Affiliated Hospital of Kunming Medical University
2022-2024
Kunming Medical University
2022-2024
Northwest A&F University
2021-2024
Hunan Academy of Agricultural Sciences
2022
Academe of Grassland And Animal Science
2022
Guangxi Medical University
2019-2021
Guangxi University
2019
Shanghai Tenth People's Hospital
2017
Tongji University
2017
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across wide range of agro-ecosystems, from extremely hot semiarid regions humid tropical regions. However, their adaptive genetic changes following dispersal into East Asia the Indian subcontinent have remained poorly documented. Here, we characterize global diversity using high-quality whole-genome sequencing data 354 indicine cattle 57 breeds/populations, including major...
Abstract Background Structural variations (SVs) in individual genomes are major determinants of complex traits, including adaptability to environmental variables. The Mongolian and Hainan cattle breeds East Asia taurine indicine origins that have evolved adapt cold hot environments, respectively. However, few studies investigated SVs Asian their roles adaptation, little is known about adaptively introgressed cattle. Results In this study, we examine the climate adaptation these two lineages...
Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion EGFR subtypes in and evaluated TMB level, PD-L1 expression level tumor immune microenvironment among different mutation subtypes. Postoperative follow-up for 98 patients were collected analyzed. The results showed that several uncommon have a higher TMB-high or strong positive than total group. In addition, characteristics related to microenvironment, such as G719 mutations being associated with...
Abstract White coat pigmentation is a striking phenotype of many domesticated species and has various genetic controls. The Tianzhu yak, an indigenous breed with complete white coat, fascinated Tibetans for centuries. However, the basis this trait remains unknown. Here, we conducted population genomics analysis genome‐wide association study based on whole‐genome sequencing data 38 59 non‐white‐coated yak. results revealed presence KIT ‐linked Cs alleles characterized by translocations...
Understanding the genetic diversity in Xiangxi cattle may facilitate our efforts toward further breeding programs. Here we compared 23 with 78 published genomes of 6 worldwide representative breeds to characterize genomic variations cattle. Based on clustering models population structure analysis, displayed that had a mutual genome ancestor Chinese indicine, Indian and East Asian taurine. Population was analyzed by four methods (nucleotide diversity, inbreeding coefficient, linkage...
Manganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear.This was a cross-sectional study. Data were collected from 2017 Mn-exposed workers healthy cohort (MEWHC). Finally, 803 occupationally included The divided into two groups. grouping of this study based on Mn-Time Weighted Averages (Mn-TWA). high-exposure group participants with Mn-TWA greater than 0.15 mg/m3. low-exposure less or equal to levels assessed.After...
Abstract Background Elevated exposure to manganese (Mn) could induce cardiovascular dysfunction. However, limited research is available on the effects of occupational Mn myocardial enzymes. We aimed evaluate relationships between and enzyme elevation among Mn‐exposed workers. Methods Data were from a follow‐up investigation workers healthy cohort in 2017. A total 744 divided into low‐exposure high‐exposure groups according time‐weighted average (Mn‐TWA) less than or equal 0.15 mg/m 3 greater...
Human are widely exposed to multiple metals, some of which have suspected reproductive toxicity, but no human studies investigated the developmental effects prenatal metal exposure. We aimed evaluate associations between exposure and development in boys at 2–3 years using multi-pollutant approach. This prospective study used data 564 mother–child pairs recruited from Guangxi Birth Cohort Study. Twenty serum concentrations were measured. Least absolute shrinkage selection operator (LASSO)...
This study aimed to evaluate the difference of mass in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) characteristics between low-risk and non-low-risk breast cancers explore possible pathological basis.Approval from institutional review board informed consent were acquired for this study. The MR images 104 patients with pathologically proven cancer (104 lesions) prospectively analyzed. All included Chinese woman. DCE-MRI morphologic findings, apparent diffusion coefficient...
Numerous studies have shown that several microRNAs (miRNAs) are specifically expressed in testis, play an essential role regulating testicular spermatogenesis. Hainan and Mongolian cattle two representative Chinese native breeds representing Bos indicus (indicine cattle) taurus (taurine cattle), respectively, which distributed hot cold Inner Mongolia province. To study the functional differences of miRNA spermatogenesis between indicine taurine cattle, six mature testes samples from (n = 3)...
The diversity of livestock coat color results from human positive selection and is an indispensable part breed registration. As important biodiversity resource, Asiatic wild ass has many special characteristics, including the most visualized feature, its yellowish-brown color, excellent adaptation. To explore genetic mechanisms phenotypic characteristics in hybrids, we resequenced whole genome one Mongolian Kulan (a subspecies ass) 29 hybrids (Mongolian ♂×Xinjiang♀), ancestor composition...
Yunling cattle (YL) is a recently developed beef breed harboring quarter of Yunnan ancestral genome, spanning over past 30 years. Compared with Diqing (DQ), native breed, YL presents various advantages, including rapid growth and exquisite meat quality. However, the molecular mechanisms underlying these phenotypic differences are not clearly understood. To further identify candidate genes responsible for quality in muscle, longissimus dorsi (LD) muscle was used RNA-Seq analysis. A total 508...
Lung cancer is one of the most frequently diagnosed cancers worldwide, associated with a poor survival rate. Taxol (Paclitaxel) commonly used as chemotherapeutic treatment for advanced lung cancers. While has improved clinical outcomes patients, significant number them develop resistance to Taxol, resulting in failure. The role long noncoding RNA HCG18 and not yet been fully understood. To investigate this, we examined expression miR-34a-5p tumors normal tissues using qRT-PCR. We also...
<title>Abstract</title> Background Lung cancer is a leading cause of mortality, with non-small cell lung (NSCLC) accounting for the majority cases. Standard treatment early-stage NSCLC involves surgical resection, often complemented by adjuvant therapies. This study explores dynamics minimal residual disease (MRD) in NSCLC, emphasizing prognostic value baseline clinical characteristics. Methods We conducted prospective enrolling 78 patients operable stage I-IIIA NSCLC. Serial blood samples...