A5070345176- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Carcinogens and Genotoxicity Assessment
- Nigella sativa pharmacological applications
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
Yan'an Hospital Affiliated To Kunming Medical University
2019-2025
Kunming Medical University
2019-2025
WinnMed
2019
AbbVie (United States)
2019
Abstract Background: Phosphorylation is a critical post-translational modification regulating key biological processes. CDC20 regulator in cell cycle control, but its phosphorylation's role Uterine Corpus Endometrial Carcinoma (UCEC) not well understood. Methods: We used two datasets from the Clinical Proteomic Tumor Analysis Consortium (CPTAC). PDC000126 was training set, and PDC000441 for validation. Both contained proteomic phosphoproteomic data. Differentially expressed phosphorylation...
Synchronous colorectal liver metastasis (SCLM) had limited availability of tools to predict survival and tumor recurrence. LncRNA CRNDE lncRNA SNHG7 have been proven be closely related cancer progression. However, the predictive value in prognosis is still unclear. The purpose this study was investigate whether could used as promising biomarkers for prediction SCLM patients who underwent hepatectomy.The expression profile serum examined by qRT-PCR. relationship between clinicopathological...
Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion EGFR subtypes in and evaluated TMB level, PD-L1 expression level tumor immune microenvironment among different mutation subtypes. Postoperative follow-up for 98 patients were collected analyzed. The results showed that several uncommon have a higher TMB-high or strong positive than total group. In addition, characteristics related to microenvironment, such as G719 mutations being associated with...
The incidence of lung cancer in Yunnan area ranks firstly the world and underlying molecular mechanisms region are still unclear. We screened a novel potential oncogene CYP2S1 used mRNA microassay bioinformation database. function has not been reported.To investigate functions cancer.Immunohistochemistry Real-time PCR were to verify expression CYP2S1. Colony formation Transwell assays determine cell proliferation, invasion migration. Xenograft detected growth vivo.CYP2S1 is significantly...
Breast cancer is a highly heterogeneous disease and numerous secreted factors may differentially contribute to macrophage phenotype whose extensive infiltration generally regarded as indicative of an unfavorable outcome. How different breast tumor cells interplay or influence each other on the alternative splicing (AS) level have not been characterized. Here, we exploited one previous study, which investigated between macrophages estrogen receptor‑positive (ER+) triple‑negative (TNBC) at...
Cell division cycle 42 (CDC42) regulates the progression of leukemia via mediating proliferation and immune evasion malignant cells. The study aimed to investigate correlation CDC42 with clinical features, treatment response, event-free survival (EFS) overall (OS) in adult Philadelphia chromosome negative acute lymphoblastic (Ph− ALL) patients. expression bone marrow mononuclear cells was detected 78 Ph− ALL patients 10 donors using real-time reverse transcriptase-polymerase chain reaction....
Although tamoxifen (TMX) belongs to selective estrogen receptor modulators (SERMs) and selectively binds receptors, it affects other estrogen-producing tissues due passive diffusion non-differentiation of normal cancerous cells leads side effects. The problems expressed about encouraged us design a new drug delivery system based on magnetic nanoparticles (MNPs) simultaneously target two receptors cancer through folic acid (FA) hyaluronic (HA) groups. mediator binding targeting agents MNPs is...
Background: We have previously reported that ∼50% of CLL patients (pts) experience rapid flare disease when they discontinue ibrutinib therapy due to progression (CLL or Richter's transformation [RT]) (Hampel et al, JCO suppl , 2018). This lead the clinical practice overlapping venetoclax with for combination in this setting prevent withdrawal. Aims: To evaluate role continuing beyond start salvage pts who on monotherapy, both preventing withdrawal associated discontinuation and response....