A5078227951- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Lung Cancer Treatments and Mutations
- Photoacoustic and Ultrasonic Imaging
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Analysis
- Ophthalmology and Eye Disorders
- Cancer Genomics and Diagnostics
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Sports injuries and prevention
- Ultrasound and Hyperthermia Applications
- Spine and Intervertebral Disc Pathology
- Radiation Dose and Imaging
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Lower Extremity Biomechanics and Pathologies
- Ultrasound Imaging and Elastography
- Lung Cancer Research Studies
First Affiliated Hospital of Zhengzhou University
2023-2025
University of California, San Diego
2018-2024
Chinese Academy of Sciences
2020-2024
First Affiliated Hospital of Kunming Medical University
2008-2024
Kunming Medical University
2009-2024
Institute of Electrical Engineering
2020-2024
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Beijing Information Science & Technology University
2023
Nantong University
2023
Purpose To measure T 1 relaxations for the major tissues in whole knee joints on a clinical 3T scanner. Methods The 3D UTE‐Cones actual flip angle imaging (AFI) method was used to map transmission radiofrequency field (B ) both short and long 2 tissues, which then correct variable (VFA) fitting generate accurate maps. Numerical simulation carried out investigate accuracy of measurement range values, excitation pulse durations, B errors. Then, AFI‐VFA applied healthy volunteers ( N = 16)...
Background Water signal contamination is a major challenge for direct ultrashort echo time (UTE) imaging of myelin in vivo because water contributes most the signals detected white matter. Purpose To validate new short repetition (TR) adiabatic inversion recovery (STAIR) prepared UTE (STAIR-UTE) sequence designed to suppress and allow T2 protons matter using clinical 3-T scanner. Materials Methods In this prospective study, an optimization framework was used obtain optimal nulling STAIR-UTE...
Purpose To investigate direct imaging of trabecular bone using a 3D adiabatic inversion recovery prepared ultrashort TE cones (3D IR‐UTE‐Cones) sequence. Methods The proposed IR‐UTE‐Cones sequence used broadband pulse together with short TR/TI combination to suppress signals from long T 2 tissues such as muscle and marrow fat, followed by multispoke UTE acquisition detect signal water components in bone. feasibility this technique for robust suppression was first demonstrated through...
Purpose To investigate the effect of stretching sampling window on quantitative 3D ultrashort TE (UTE) imaging cortical bone at 3 T. Methods Ten bovine and 17 human tibial midshaft samples were imaged with a 3T clinical MRI scanner using an 8‐channel knee coil. Quantitative UTE biomarkers, including T 1 , magnetization transfer ratio modeling, performed radial or spiral Cones trajectories various durations. Errors in UTE‐MRI biomarkers as function time evaluated reference standard. Results...
Purpose In ultrashort echo time (UTE) imaging, fat suppression can improve short T 2 * contrast but also reduce signals. The conventional two‐point Dixon (2p‐Dixon) method does not perform well due to decay. this study, we propose a new suppress for high UTE imaging of tissues, utilizing single‐point (1p‐Dixon) method. Methods proposed utilizes dual‐echo where is followed by the second TE, chosen flexibly. Fat estimated applying 1p‐Dixon non‐UTE image after correction phase errors, which...
Background: Newer Oral Anticoagulants (NOACs) offer potential advantages for patients with cerebral venous sinus thrombosis (CVST). However, there is a lack of evidence to evaluate the efficacy and safety NOACs in CVST. The purpose this study was compare benefit between warfarin CVST based on propensity score matching. Methods: We performed single-center prospective analysis including from First Affiliated Hospital Zhengzhou University January 1, 2018 December 31, 2021. primary outcome...
Abstract Clinical magnetic resonance imaging (MRI) sequences are not often capable of directly visualizing tendons. Ultrashort echo time (UTE) MRI can acquire high signal from tendons thus enabling quantitative assessments. Magnetization transfer (MT) modeling combined with UTE-MRI—UTE-MT-modeling—can indirectly assess macromolecular protons in the tendon. This study aimed to determine if UTE-MT-modeling is a technique sensitive age-related changes The legs 26 young healthy (29 ± 6 years...
Background Relatively weak correlations between patient symptoms and rotator cuff tendon (RCT) tearing have been reported; however, the relationship tendinosis has less well‐studied. Purpose/Hypothesis To use quantitative MRI to assess bilateral RCTs in shoulders of both patients with unilateral symptomatic tendinopathy control subjects. We hypothesized that measures would differ controls. Study Type Prospective imaging study. Population/Subjects In all, 48 from 24 subjects (mean age, 32.8...
Background Recent studies suggest that macromolecular fraction (MMF) derived from three‐dimensional ultrashort echo time magnetization transfer (UTE‐MT) imaging is insensitive to the magic angle effect. However, its clinical use in osteoarthritis (OA) remains be investigated. Purpose To investigate feasibility of 3D UTE‐MT‐derived MMF differentiating normal degenerated cartilage. Study Type Prospective. Subjects Sixty‐two participants (54.8 ± 16.7 years, 30 females) with and without OA, plus...
Ultra-short echo time (UTE) MRI with post-processing is a promising technique in bone imaging that produces similar contrast to computed tomography (CT). Here, we propose 3D slab-selective ultrashort sequence together image structures the lumbar spine. We also explore intermodality agreement between UTE and CT images. The spines of two healthy volunteers were imaged using five different resolutions determine best protocol. Then, four patients low back pain both investigate methods. Two other...
Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion EGFR subtypes in and evaluated TMB level, PD-L1 expression level tumor immune microenvironment among different mutation subtypes. Postoperative follow-up for 98 patients were collected analyzed. The results showed that several uncommon have a higher TMB-high or strong positive than total group. In addition, characteristics related to microenvironment, such as G719 mutations being associated with...
Abstract Background Emerging evidence has underscored infiltrating immune cells in the tumor microenvironment (TME) of non‐small cell lung cancer (NSCLC). Owing to screening programs, prevalence early‐stage NSCLC is growing, but its high recurrence risk and poor survival impose an increasing demand for further understanding TME. Methods Tissue plasma samples from 33 resectable stage IA patients were collected surgery subject histological genomic analyses. The distribution CD8+ T cells,...
Tendons and bones comprise a special interacting unit where mechanical, biochemical, metabolic interplays are continuously in effect. Bone loss osteoporosis (OPo) its earlier stage disease, osteopenia (OPe), may be coupled with reduction tendon quality. Noninvasive means for quantitatively evaluating quality during disease progression critically important the improvement of characterization treatment optimization patients bone mineral density disorders. Though clinical magnetic resonance...
Knee degeneration involves all the major tissues in joint. However, conventional MRI sequences can only detect signals from long T2 such as superficial cartilage, with little signal deep menisci, ligaments, tendons and bone. It is highly desirable to develop new that knee. We aimed a comprehensive quantitative three-dimensional ultrashort echo time (3D UTE) cones imaging protocol for truly "whole joint" evaluation of knee degeneration. The included 3D UTE actual flip angle UTE-Cones-AFI) T1...
Purpose: To prospectively investigate the effect of thyroid arterial embolization on hyperthyroid Graves' disease in selected patients. Material and Methods: Twenty-eight patients with hyperthyroidism caused by were enrolled to undergo followed up for 12–22 months. Twenty-two had three arteries embolized six two arteries. Serum hormone, thyroid-stimulating hormone (TSH), autoimmune function tested before after all Results: Of 28 patients, 22 (78.6%) became euthyroid, five improved (17.8%),...
Hepatoid adenocarcinoma (HAC) occurs in extrahepatic organs such as the gastrointestinal tract, testes, ovaries, lungs, mediastinum and pancreas, frequently produces α-fetoprotein (AFP). HAC of lung (HAL) is rare, characterized by difficult treatment poor prognosis. There are no reports HAL Yunnan-Guizhou Plateau, China.A 60-year-old male patient was clinically diagnosed with pT3N0M0, stage IIB. Chest computed tomography revealed a 7.5 cm × 7.2 soft tissue mass located right upper lobe...
Purpose Inversion recovery‐based UTE (IR‐UTE) sequences have been proposed to directly image myelin with extremely short (~0.3 ms). In this study, we demonstrate the feasibility of complex echo subtraction improve 3D IR‐UTE imaging in white matter brain vivo. Methods imaging, long T 2 components (i.e., water) are suppressed using an adiabatic inversion recovery preparation pulse. Dual data acquisition and magnitude used suppress residual gray signals, providing high contrast. Complex may...
Purpose We describe the measurement of bound water T 1 ( ) cortical bone in vitro and vivo with a 3D adiabatic inversion recovery ultrashort echo time (IR‐UTE) Cones sequence using clinical 3T scanner. Methods A series IR‐UTE data from 6 repetition times (TRs) 5 (TIs) at each TR were acquired 12 human tibial specimens, 4 TRs TIs midshafts 8 healthy volunteers. The pore nulling point was calculated exponential fitting curve TR. Bone specimens volunteers then scanned again derived through...
Abstract While conventional MRI sequences cannot visualize tissues from the osteochondral junction (OCJ) due to these tissues' short transverse T 2 /T * relaxations, ultrashort echo time (UTE) can overcome this limitation. A 2D UTE sequence with a dual adiabatic inversion recovery preparation (DIR‐UTE) for selective imaging of high contrast has previously been developed, but sensitivity eddy currents and aliased out‐of‐slice excitation make it difficult image thin layer OCJ in vivo. Here, we...