A5101681615- Epigenetics and DNA Methylation
- Spectroscopy and Chemometric Analyses
- Natural Compounds in Disease Treatment
- Autophagy in Disease and Therapy
- Autoimmune and Inflammatory Disorders Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Text Analysis Techniques
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Diabetic Foot Ulcer Assessment and Management
- Nitric Oxide and Endothelin Effects
- Cancer, Lipids, and Metabolism
- Complex Network Analysis Techniques
- Nutrition, Genetics, and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Angiogenesis and VEGF in Cancer
- Sentiment Analysis and Opinion Mining
- Wound Healing and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- TGF-β signaling in diseases
- Plant Gene Expression Analysis
China Pharmaceutical University
2023-2025
Nanjing Drum Tower Hospital
2023-2025
Xuzhou Medical College
2025
Binzhou University
2012-2024
Binzhou Medical University
2007-2024
Second Affiliated Hospital of Soochow University
2020-2024
Soochow University
2020-2024
Jingzhou Central Hospital
2024
Shuozhou Central Hospital
2024
Northeastern University
2013-2023
Excessive oxidative stress and lipid peroxidation have been demonstrated to play important roles in the production of liver damage. L-carnitine is a natural substance acts as carrier for fatty acids across inner mitochondrial membrane subsequent beta-oxidation. It also an antioxidant that reduces metabolic cells. Recent years has proposed treatment various kinds disease, including injury. This study was conducted evaluate protective effect against hydrogen peroxide (H2O2)-induced...
Abstract Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions cancer autophagy remains unknown. This study investigated the effects on HCC cells. The role was studied two lines, PLC/PRF/5 and HLE. Cell autophagy, apoptosis, proliferation, migration invasion were analysed with Western blotting, co-immunoprecipitation (CoIP), immunofluorescence, animal models, MTT assays, flow cytometry (FCM),...
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder of the synovial joints. Celastrol (Cel) quinone-methylated triterpenoid extracted from Tripterygium wilfordii Hook F (TwHF) that has been proven to be effective in treating RA. However, underlying molecular mechanism celastrol treatment RA remains unknown. This study explored protective effect against and specific mechanisms vitro vivo.A chicken type II collagen (CII)-induced (CIA) mouse model was used explore...
Colorectal cancer ( CRC ) accounts for over 600 000 deaths annually worldwide. The current study aims to evaluate the value of proto‐oncogene PIM 1 as a therapeutic target in and investigate anticancer activity hispidulin, naturally occurring phenolic flavonoid compound, against . Immunohistochemistry analysis showed that was upregulated tissue. role an oncogene evidenced by fact knockdown inhibits cell growth, induces apoptosis, suppresses invasion. Our results hispidulin exerts antitumor...
Tree peony is a "spring colored-leaf" plant which has red leaves in early spring, and the color of usually fades late spring. Flavonols are one subgroup flavonoids, they affect organs' as co-pigments anthocyanins. To investigate variation mechanism tree peony, PqMYBF1, flavonol biosynthesis-related MYB gene was isolated from Paeonia qiui characterized. PqMYBF1 contained SG7 SG7-2 motifs unique flavonol-specific regulators. Subcellular localization transactivation assay showed that localized...
Background Immune checkpointinhibitors (ICIs)-associated cardiotoxic events (CEs) are of increasing concern.Existing research about glucocorticoids (GCs) on immunotherapy focused ICIs'efficacy and patients' outcome. The influence GCs ICIs-associated CEs andmyocardial damage (MD) remains unknown.
Abstract Background: Paired-like homeodomain transcription factor 1 (PITX1) participates in miscellaneous biological processes including cell growth, development, progression and invasion various malignant tumors. However, the analysis of association between PITX1 expression survival breast cancer remains unclear. Methods: Clinical prognostic parameters data related to patients were performed using bioinformatic Oncomine, Bc-GenExMiner v4.3, PrognoScan UCSC Xena. Results: We found that gene...
Paeonia qiui is a wild species of tree peony native to China. Its leaves are purplish red from the bud germination flowering stage, and anthocyanin main pigment in leaves. However, synthesis regulation mechanism remains unclear. In this study, an R2R3-MYB, PqMYB113 was identified P. qiui. Phylogenetic analysis revealed that clustered with Liquidambar LfMYB113 grape VvMYBA6. Subcellular location showed located cell nucleus. The transient reporter assay suggested transcriptional activator....
It is challenging to build domain-specific emotional lexicon for film reviews, due its unique characteristics, such as massive data, endless new login words, and others. To improve the accuracy of reviews classification, this article proposes a method extending based on word distance point mutual information. First, using improved K-means++ algorithm cluster select seed words with obvious tendencies. Next, Distance Word Point Mutual Information (DW-PMI) presented determine polarity in domain...
Abstract Evidence indicated that GATA5 may suppress hepatocellular carcinoma (HCC) cell malignant transformation, but the mechanism of how affects cancer reprogramming to inhibit HCC behaviour is still unclear. In this study, we report expression β‐catenin and genes p‐Oct4, Nanog, Klf4, c‐myc EpCAM was significantly higher in tissues compared normal liver tissues. contrast, lower Transfection CDH‐GATA5 vectors into cells (HLE, Bel 7402 PLC/PRF/5 cells) increased decreased EpCAM. Increased by...
Abstract Diabetes is one of the common chronic diseases in worldwide and increasing among young children. Testing glycated hemoglobin levels as well blood glucose a method for detecting diabetes. In this article, with multivariate statistical analysis was used to monitor by Fourier Transform Raman spectroscopy. Principal component regression direct orthogonal signal correction developed applied analyze concentration The root means square error calibration 3.0824 mg/dL (0.1712 mmol/L),...