A5100398797- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Glycosylation and Glycoproteins Research
- Cancer Risks and Factors
- Berberine and alkaloids research
- Tryptophan and brain disorders
- Cancer-related Molecular Pathways
- Fatty Acid Research and Health
- Synthesis and Biological Activity
- Metabolism, Diabetes, and Cancer
- Stress Responses and Cortisol
- Asymmetric Synthesis and Catalysis
- Cholinesterase and Neurodegenerative Diseases
- Advanced Electron Microscopy Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Metastasis and carcinoma case studies
- Drug Transport and Resistance Mechanisms
- Bioinformatics and Genomic Networks
- Pancreatic and Hepatic Oncology Research
- Synthesis and bioactivity of alkaloids
- Piperaceae Chemical and Biological Studies
- Electron and X-Ray Spectroscopy Techniques
- Metabolomics and Mass Spectrometry Studies
Hainan Medical College Hospital
2017-2024
Hainan Medical University
2024
Tibet Autonomous Region People's Hospital
2023
Zunyi Medical University
2022
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2021
Shanghai Jiao Tong University
2018
Jining Medical University
2014
Kyoto University
2011
Abstract Cryo-electron microscopy (cryo-EM) visualizes the atomic structure of macromolecules that are embedded in vitrified thin ice at their close-to-native state. However, homogeneity thickness, a key factor to ensure high image quality, is poorly controlled during specimen preparation and has become one main challenges for high-resolution cryo-EM. Here we found uniformity relies on surface flatness supporting film, developed method use ultraflat graphene (UFG) as support cryo-EM achieve...
Abstract Alpha-fetoprotein (AFP), a serum glycoprotein, is expressed during embryonic development and the pathogenesis of liver cancer. It serves as clinical tumor marker, function carcinogen, immune suppressor, transport vehicle; but detailed AFP structural information has not yet been reported. In this study, we used single-particle cryo-electron microscopy(cryo-EM) to analyze structure recombinant obtained 3.31 Å cryo-EM built an atomic model AFP. We observed identified certain features...
// Yi Chen 1, 2, * , Haixia Xu Mingyue Zhu 2 Kun Liu Bo Lin Ruxian Luo 3 Chuanbai and Mengsen Li 1 Key Laboratory of Molecular Biology, Hainan Medical College, Haikou 571199, Province, P. R. China Provincial Carcinogenesis Intervention, Department Psychiatry, Anning Hospital, These authors have contributed equally to this work are co-first Correspondence to: Li, email: mengsenli@163.com Chen, 812450325@qq.com Keywords: depressive model, tryptophan hydroxylase, epigenetics Received: March 14,...
Abstract Evidence indicated that GATA5 may suppress hepatocellular carcinoma (HCC) cell malignant transformation, but the mechanism of how affects cancer reprogramming to inhibit HCC behaviour is still unclear. In this study, we report expression β‐catenin and genes p‐Oct4, Nanog, Klf4, c‐myc EpCAM was significantly higher in tissues compared normal liver tissues. contrast, lower Transfection CDH‐GATA5 vectors into cells (HLE, Bel 7402 PLC/PRF/5 cells) increased decreased EpCAM. Increased by...
Background: Prostate cancer (PCa) is an epithelial malignant tumor that occurs in the urinary system with high incidence and second most common among men world. Thus, it important to screen out potential key biomarkers for pathogenesis prognosis of PCa. The present study aimed identify reveal underlying molecular mechanisms. Methods: Differentially expressed genes (DEGs) between PCa tissues matched normal from Cancer Genome Atlas Adenocarcinoma (TCGA-PRAD) dataset were screened by R...
Prostate apoptosis response protein-4 (PAR-4) is considered a tumor suppressor. However, the role of PAR-4 in hepatocellular carcinoma (HCC) has rarely been reported. The study explores malignant behaviors HCC cells.
Breast cancer is one of the major malignancies threatening women's health worldwide. The incidence breast at high altitudes increased over years. But few studies focused on characteristics clinicopathology and molecular subtypes among altitudes, which are still unknown. Tibet, with an average altitude 4000 meters, a representative city lying in Qinghai-Tibetan Plateau southwestern China. This study aimed to identify clinicopathological features Tibetan women cancer, provide evidence for...
Background: Macular neovascular disease is a group disorder with complex pathogenesis of neovascularization for vision impairment and irreversible blindness, posing great challenges to precise diagnosis management. Methods: We conducted cross-sectional association study identify serum-based potential biomarkers human macular disease. prospectively recruited participants age-related degeneration (AMD), polypoidal choroidal vasculopathy (PCV) pathological myopia (PM), compared cataract...
Abstract Background : Vincosamide(Vinco) was first identified in the methanolic extract of leaves Psychotria leiocarpa , and Vinco has important anti-inflammatory effects activity against cholinesterase, also a trait to ant-tumor. However, whether is able inhibit malignant behaviors hepatocellular carcinoma(HCC) cells still unclear. In present study, we explored role suppressing HCC cells. Methods MTT, trypan blue exclusion assay Cell Counting Kit(CCK)-8 analysis were applied detect...
Vincosamide (Vinco) was first identified in the methanolic extract of leaves Psychotria leiocarpa, and Vinco has important anti-inflammatory effects activity against cholinesterase, also a trait to anti-tumor. However, whether can inhibit malignant behaviors hepatocellular carcinoma (HCC) cells is still unclear. In present study, we explored role suppressing HCC cells.MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide), trypan blue exclusion assay, Cell Counting Kit (CCK)-8...