A5065882373- Metabolomics and Mass Spectrometry Studies
- Retinal Diseases and Treatments
- Traditional Chinese Medicine Studies
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Flavonoids in Medical Research
- Neurological Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Retinopathy of Prematurity Studies
- Traditional Chinese Medicine Analysis
- Lipid metabolism and disorders
- Acute Ischemic Stroke Management
- Chronic Kidney Disease and Diabetes
- Retinoids in leukemia and cellular processes
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Lipid metabolism and biosynthesis
Xiamen University
2023-2025
Fujian Medical University
2023-2025
Fujian University of Traditional Chinese Medicine
2025
Shanghai Jiao Tong University
2018-2024
Shanghai First People's Hospital
2019-2024
Shanghai Eye Disease Prevention & Treatment Center
2021-2024
117th Hospital of People's Liberation Army
2024
First Affiliated Hospital of Xiamen University
2023
Peking University
1991-2022
Peking University Cancer Hospital
1991-2022
Purpose: To determine the differences of metabolites and metabolic pathways between patients with proliferative diabetic retinopathy (PDR) without diabetes (nondiabetic controls) in plasma vitreous, respectively, to characterize relationship vitreous profiles. Methods: Liquid chromatography/tandem mass spectrometry technology was performed distinct metabolite profiles vitreous. A total 139 samples from 88 PDR 51 nondiabetic controls, as well 74 23 were screened. Pathway analysis using...
Empagliflozin (EMPA) is the first sodium-glucose co-transporter 2 inhibitor to significantly reduce cardiovascular and kidney complications in type diabetes mellitus. Given this, we speculate that EMPA may have potential intervene diabetic retinopathy (DR), which another diabetes-specific microvascular complication. Db/db mice were treated with for different periods observe retinas related mechanisms. effectively balanced body weight blood glucose levels, mitigated ocular edema microaneurysm...
Recent studies show branched-chain amino acid (BCAA) catabolic pathway is defective in obese animals and humans, contributing to the pathogenesis of insulin resistance diabetes. However, context obesity, various processes including dysfunctional lipid metabolism can affect sensitivity glycemic regulation. It remains unclear how BCAA defect may exert direct impacts on glucose without disturbance obesity. The current study characterized lean mice which genetic deletion PP2Cm leads moderate...
Retinal hard exudates (HEs) result from lipoproteins leaking capillaries into extracellular retinal space, and are related to decreased visual acuity in diabetic retinopathy (DR). This study aims identify differential serum lipids metabolites associated with HEs.A cross-sectional was conducted Jul 2017 ∼ Mar 2021. We assessed the amount of HEs using standard ETDRS photographs for comparison. severity rated as "no or questionable", "moderate" "severe". Serum samples were processed via high...
Abstract Background Diabetes mellitus (DM) is a progressive disease that involves multiple organs due to increased blood glucose, and diabetic retinopathy (DR) the main complication of DM in eyes causes irreversible vision loss. In pathogenesis vascular disease, oxidative stress caused by hyperglycemia plays an important role Müller cell impairment. recent years, AdipoRon, adiponectin analog demonstrated physiological functions obesity, diabetes, inflammation, cardiovascular diseases,...
Abstract Background The aim of the study was to explore a feasible method for alleviating limb ischemia–reperfusion injury (LI/RI) through use high‐concentration citrate solution (HC‐A solution) perfusion (LP). Methods Eighteen pigs were divided into three groups: Sham group, LI/RI and HCA group. group underwent exposure iliac artery vein. tourniquet placement clamping vein simulate LI/RI. received HC‐A LP 30 min left below level blood flow occlusion based on Oxidative stress markers...
Diabetic retinopathy (DR) is the leading cause of acquired blindness in middle-aged people. The complex pathology DR difficult to dissect, given convoluted cytoarchitecture retina. Here, we performed single-cell RNA sequencing (scRNA-seq) retina from a model type 2 diabetes, induced leptin receptor-deficient (db/db) and control db/m mice, with aim elucidating factors mediating pathogenesis DR. We identified 11 cell types determined cell-type-specific expression DR-associated loci via...
HIV-1 transactivator protein, Tat, has been identified as an activator of replication. It also dysregulates cytokine production and apoptosis in T-cells. Of the various cell death processes, autophagy is a self-digestion degradation mechanism that recycles contents cytosol, including macromolecules cellular organelles, resulting self-repair conservation for survival. Recent reports demonstrated autophagosomes can be activated by interferon-γ (IFN-γ) to participate immune defence processing...
SYVN1, a gene involved in endoplasmic reticulum-associated degradation, has been found to exert protective effect by inhibiting inflammation retinopathy. This study aimed clarify whether SYVN1 is the pathogenesis of retinopathy prematurity (ROP) and its potential as candidate for target therapy.Human retinal microvascular endothelial cells (hRMECs) mouse model oxygen-induced (OIR) were used reveal development-associated protein expression molecular mechanism. An adenovirus overexpressing or...
In Traditional Chinese Medicine (TCM), treatment based on ZHENG (also called TCM syndrome and pattern) differentiation has been applied for about 3 thousand years, while there are some difficulties to communicate with western medicine. the present work, metabonomic methods were utilized differentiate types evaluate therapeutic efficiency of Fuzhenghuayu (FZHY) tablet in hepatitis-B-caused cirrhosis (HBC). Urine samples 12 healthy volunteers (control group, CG) 31 HBC patients (HBCG) analyzed...
Xiao Chai Hu Tang (XCHT), a compound formula originally recorded in an ancient Chinese medical book Shanghanlun , has been used to treat chronic liver diseases for long period of time China. Although extensive studies have demonstrated the efficacy this hepatitis, hepatic fibrosis, and hepatocarcinoma, how it works against these still awaits full understanding. Here, we firstly present overview arranging from entire mechanism single herb XCHT their active components, new perspective...
As a vision-threatening complication of diabetes mellitus (DM), proliferative diabetic retinopathy (PDR) is associated with sustained metabolic disorders. Herein, we collected the vitreous cavity fluid 49 patients PDR and 23 control subjects without DM for metabolomics lipidomics analyses. Multivariate statistical methods were performed to explore relationships between samples. For each group metabolites, gene set variation analysis scores generated, constructed lipid network by using...
Tongue coating is one of the important foundations tongue diagnosis in traditional Chinese medicine (TCM) and plays an role reflecting occurrence, development, prognosis disease. However, its material basis still poorly understood. In this study, a urinary metabonomic method based on gas chromatography coupled to mass spectrometry (GC/MS) was developed. The distinct clustering metabolic profile observed from Group A (thick yellow patients with chronic hepatitis B), B white C (thin healthy...
The macular neovascular disease is a group disorder with complex pathogenesis of neovascularization for vision impairment and irreversible blindness, posing great challenges to precise diagnosis management. We prospectively recruited participants age-related degeneration (AMD), polypoidal choroidal vasculopathy (PCV), pathological myopia (PM) compared cataract patients without fundus diseases as control group. serum metabolome was profiled by gas chromatography coupled time-of-flight mass...
Recent growing evidence suggests a role for intestinal microbiome and metabolites in patients' postoperative recovery. Therefore, there is need to gain insight into the impact of pancreaticoduodenectomy periampullary carcinoma on potential their changes condition. Based 16S rDNA gene sequencing untargeted metabolomic analysis, we found that diversity abundance were significantly higher patients preoperatively than postoperatively, level probiotics was lower after surgery compared with...
Abstract Aims This study aimed to investigate branched-chain amino acid (BCAA) catabolism in diabetic retinopathy (DR). Methods Wild-type and db/db mice were fed BCAAs (5 or 10 mg/kg/day) for 12 weeks, hyperglycemia-exposed Müller cells treated with (2 5 mmol/L) 24 48 h. BCAA levels measured using MS/MS. Western blotting was performed detect proteins. Flow cytometry, oxygen consumption rate, Cell Counting Kit-8 assays used evaluate cell viability. Each experiment conducted at least thrice....
With the hope to provide an effective approach for personalized diagnosis and treatment clinically, traditional chinese medicine (TCM) is being paid increasing attention as a complementary alternative medicine. It performs based on ZHENG (TCM syndrome) classification, which could be identified clinical special phenotypes by symptoms signs of patients even if they have different disease. However, it caused controversy because classification only depends observation, knowledge, experience TCM...
The phenomenon that the same syndrome turns up in different diseases appears sight of people around world, which raises thought for possibility "Same Treatment Different Diseases." Actually, treatment based on ZHENG classification Traditional Chinese Medicine could bring revelation former finding. dampness-heat chronic hepatitis B and nonalcoholic fatty liver is regarded as breakthrough point. We discussed molecular mechanism similar connotation exists by metabonomics to give modern...
Traditional Chinese medicine (TCM) physicians stratify patients with the same disease into different subtypes in order to guide appropriate treatment, which is called Zheng (TCM syndrome) classification. Excess and deficiency ZHENG a couple of basic ZHENGs maladjusted body nature, reflecting struggling state human pathogenic factor important prevalently exists classification many diseases. The present work using chronic hepatitis B (CHB) as an entry point explored substance connotation...