A5024628011- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Liver physiology and pathology
- Traditional Chinese Medicine Studies
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Hepatitis B Virus Studies
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
- Fetal and Pediatric Neurological Disorders
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Traditional Chinese Medicine Analysis
- Diabetes Treatment and Management
- Alzheimer's disease research and treatments
- NF-κB Signaling Pathways
- Barrier Structure and Function Studies
Shuguang Hospital
2015-2025
Shanghai University of Traditional Chinese Medicine
2015-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Johns Hopkins Medicine
2016-2023
Johns Hopkins University
2016-2023
Jiujiang First People's Hospital
2023
South China Agricultural University
2022
Zhongnan University of Economics and Law
2022
First Affiliated Hospital of Henan University of Science and Technology
2009-2019
Chronic hepatitis B (CHB) is a global epidemic disease that results from virus (HBV) infection and may progress to severe liver failure, including fibrosis, cirrhosis hepatocellular carcinoma. Previous evidence has indicated the dysbiosis of gut microbiota occurs after associated with disease. The aim this study elucidate compositional functional characteristics in early-stage CHB understand their influence on progression. We investigated microbial composition stool samples 85 patients low...
Diabetes and obesity are characterized by insulin resistance chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS) caused increased intestinal permeability during diet-induced promotes in mice. Here, we show that LPS induces endoplasmic reticulum (ER) stress protein levels P300, an acetyltransferase involved glucose production. In high-fat diet fed genetically obese ob/ob mice, P300 translocates from the nucleus into cytoplasm hepatocytes. We also...
Gut-liver axis is increasingly recognized to be involved in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD). The gut microbiota intestinal permeability have been demonstrated key players gut-liver cross talk NAFLD. Geniposide chlorogenic acid (GC) combination derived from a traditional Chinese medicine, Qushi Huayu Decoction (QHD), which has used clinic for NAFLD treatment decades China validated multiple animal models GC previously treat via modulation on...
Beneficial effects of the Chinese herbal medicine Qushi Huayu Decoction (QHD) were observed with non-alcoholic fatty liver disease (NAFLD) patients and animal models. The impact QHD or its active components (geniposide chlorogenic acid, GC) on NAFLD transcriptome gut microbiota was examined rats. Increased expression for genes required glutathione production decreased lipid synthesis in livers treated GC. GC treatment serum LPS, which could be explained by reduced mucosal damage colon...
Seawater electrolysis has garnered considerable interest as an environmentally sustainable method for hydrogen production. However, the abundance of chloride ions in seawater poses a challenge to electrocatalyst stability, underscoring need catalysts with exceptional durability and efficiency facilitate effective oxidation. In this study, thiamine pyrophosphate (TPP) was intercalated into NiFe layered double hydroxide on nickel foam (NF/NiFe LDH), creating advanced oxidation LDH@TPP) that...
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotoxin gut leakage, the subsequent Kupffer cell activation, and receptors expression. Rats were provided with Liber-DeCarli liquid diet for 8 weeks. Puerarin (90 mg/kg or 180 daily) was orally administered beginning third week until end experiment. Chronic...
Cordyceps sinensis has been used to treat liver disease in traditional Chinese medicine for thousands of years. Polysaccharide extracted from cultured mycelia (CS-PS) is the major active components cordyceps with anti-liver injury effects. In present study, effects CS-PS on hepatic stellate cell (HSC) activation, transforming growth factor-β1 (TGF-β1)/Smad pathway, as well matrix metalloproteinase (MMP) 2, MMP9 and tissue inhibitor (TIMP) 1, TIMP2, were investigated fibrosis rats induced by...
Abstract Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called “ZHENG”. The is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients receive series parameters modern clinical examination, while they are routinely believed be unrelated diagnosis. In this study, we investigated whether...
To elucidate tongue coating microbiota and metabolic differences in chronic hepatitis B (CHB) patients with yellow or white coatings.Tongue samples were collected from 53 CHB (28 25 patients) 22 healthy controls. Microbial DNA was extracted the samples, bacterial 16S ribosomal RNA gene V3 region amplified all sequenced Ion Torrent PGM™ sequencing platform according to standard protocols. The metabolites coatings evaluated using a liquid chromatography-mass spectrometry (LC-MS) platform....
Importance Ginkgo diterpene lactone meglumine (GDLM) has attracted much attention because of its potential neuroprotective properties in ischemic stroke. The efficacy GDLM patients with acute stroke (AIS) needs to be verified by well-designed randomized clinical trials. Objective To assess the and safety AIS. Design, Setting, Participants This multicenter, randomized, double-blind, placebo-controlled, parallel-group trial involved 3448 who had AIS, were aged 18 80 years, a clinically...
Metformin is the most commonly prescribed oral anti-diabetic agent worldwide. Surprisingly, about 35% of diabetic patients either lack or have a delayed response to metformin treatment, and many become less responsive over time. It remains unknown how resistance insensitivity occurs. Recently, we found that therapeutic concentrations suppressed glucose production in primary hepatocytes through AMPK; activation cAMP-PKA pathway negatively regulates AMPK activity by phosphorylating AMPKα...