A5089008822- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Microbial Community Ecology and Physiology
- Probiotics and Fermented Foods
- Wastewater Treatment and Nitrogen Removal
- Genomics and Phylogenetic Studies
- Dietary Effects on Health
- Metabolomics and Mass Spectrometry Studies
- Microbial bioremediation and biosurfactants
- Berberine and alkaloids research
- Tryptophan and brain disorders
- Plant Molecular Biology Research
- Ginseng Biological Effects and Applications
- Plant Virus Research Studies
- Circular RNAs in diseases
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ruminant Nutrition and Digestive Physiology
- Food composition and properties
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Plant Stress Responses and Tolerance
- Food Security and Health in Diverse Populations
Hangzhou Normal University
2021-2025
Lanzhou University
2025
Kunming Third People's Hospital
2025
Shanghai Jiao Tong University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Rutgers, The State University of New Jersey
2017-2024
Institute of Hematology & Blood Diseases Hospital
2022-2024
Canadian Institute for Advanced Research
2017-2024
Jiangsu Academy of Agricultural Sciences
2009-2024
Yunnan Institute of Tropical Crops
2024
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together fecal shotgun metagenomics, to show that select group SCFA-producing strains was promoted by dietary fibers most other potential producers were either diminished or unchanged patients T2DM. When the fiber-promoted...
Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (microbiome) and individual variations in the microbiome influence host health, may be implicated disease etiology, affect drug metabolism, toxicity, efficacy. However, molecular basis these microbe-host interactions roles bacterial species are obscure. We now demonstrate a"transgenomic" approach to link metabolic phenotype (metabotype) variation. used combination spectroscopic, microbiomic, multivariate...
Abstract Structural disruption of gut microbiota and associated inflammation are considered important etiological factors in high fat diet (HFD)-induced metabolic syndrome (MS). Three candidate probiotic strains, Lactobacillus paracasei CNCM I-4270 (LC), L. rhamnosus I-3690 (LR) Bifidobacterium animalis subsp. lactis I-2494 (BA), were individually administered to HFD-fed mice (108 cells day−1) for 12 weeks. Each strain attenuated weight gain macrophage infiltration into epididymal adipose...
Abstract Lipopolysaccharide endotoxin is the only known bacterial product which, when subcutaneously infused into mice in its purified form, can induce obesity and insulin resistance via an inflammation-mediated pathway. Here we show that one endotoxin-producing bacterium isolated from a morbidly obese human’s gut induced germfree mice. The Enterobacter decreased relative abundance 35% of volunteer’s bacteria to non-detectable, during which time volunteer lost 51.4 kg 174.8 initial weight...
Accumulating evidence suggests that the gut microbiota is an important factor in mediating development of obesity-related metabolic disorders, including type 2 diabetes. Metformin and berberine, two clinically effective drugs for treating diabetes, have recently been shown to exert their actions through modulating microbiota. In this study, we demonstrated metformin berberine similarly shifted overall structure rats. Both showed reverting effects on high-fat diet-induced structural changes...
Berberine, a major pharmacological component of the Chinese herb Coptis chinensis, which was originally used to treat bacterial diarrhea, has recently been demonstrated be clinically effective in alleviating type 2 diabetes. In this study, we revealed that berberine effectively prevented development obesity and insulin resistance high-fat diet (HFD)-fed rats, showed decreased food intake. Increases levels serum lipopolysaccharide-binding protein, monocyte chemoattractant protein-1, leptin...
Abstract The gut microbiota of individuals are dominated by different fiber-utilizing bacteria, which ferment dietary fiber into short chain fatty acids (SCFAs) known to be important for human health. Here, we show that the dominance Prevotella versus Bacteroides in fecal innocula, identified two enterotypes, differentially impacts vitro fermentation profiles SCFAs from fibers with chemical structures. In a microbiome enterotype, fructooligosaccharides, and sorghum corn arabinoxylans...
Calorie restriction has been regarded as the only experimental regimen that can effectively lengthen lifespan in various animal models, but actual mechanism remains controversial. The gut microbiota shown to have a pivotal role host health, and its structure is mostly shaped by diet. Here we show life-long calorie on both high-fat or low-fat diet, not voluntary exercise, significantly changes overall of C57BL/6 J mice. enriches phylotypes positively correlated with lifespan, for example,...
Abstract Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular symbionts maintaining health their hosts. Here we performed a large structural survey fecal in 314 young adults, covering 20 rural urban cohorts from 7 ethnic groups living 9 provinces throughout China. Canonical analysis unweighted UniFrac principal coordinates clustered subjects mainly...
Abstract The gut microbiota is hypothesized to have a critical role in metabolic diseases, including type 2 diabetes (T2D). A traditional Chinese herbal formula, Gegen Qinlian Decoction (GQD), can alleviate T2D. To find out whether GQD modulates the composition of during T2D treatment, 187 patients were randomly allocated receive high (HD, n=44), moderate (MD, n=52), low dose (LD, n=50) or placebo (n=41) for 12 weeks double-blinded trial. Patients who received HD MD demonstrated significant...
Gut microbiota has been implicated as a pivotal contributing factor in diet-related obesity; however, its role development of disease phenotypes human genetic obesity such Prader–Willi syndrome (PWS) remains elusive. In this hospitalized intervention trial with PWS (n = 17) and simple 21) children, diet rich non-digestible carbohydrates induced significant weight loss concomitant structural changes the gut together reduction serum antigen load alleviation inflammation. Co-abundance network...
Chronic inflammation induced by endotoxin from a dysbiotic gut microbiota contributes to the development of obesity-related metabolic disorders. Modification diet balance its composition becomes promising strategy help manage obesity. A dietary scheme based on whole grains, traditional Chinese medicinal foods, and prebiotics (WTP diet) was designed meet human nutritional needs as well microbiota. Ninety-three 123 central obese volunteers (BMI ≥ 28 kg m(-2) ) completed self-controlled...
Abiotic stresses due to environmental factors could adversely affect the growth and development of crops. Among abiotic stresses, drought heat stress are two critical threats crop sustainable agriculture worldwide. Considering global climate change, incidence combined is likely increase. The aim this study was shed light on plant performance leaf physiology three tomatoes cultivars ('Arvento', 'LA1994' 'LA2093') under control, drought, stress. Shoot fresh dry weight, area relative water...
ABSTRACT Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested hypothesis that alteration may be involved in alleviation T2DM with hyperlipidemia by metformin and specifically designed herbal formula (AMC). Four hundred fifty patients were randomly assigned to either metformin- or AMC-treated group. After 12 weeks treatment, 100 selected from each group assessed improvement. The...
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. Gut microbiota has been implicated to play critical role diseases may modulate the secretion of mediators brain-gut axis. Interaction between gut symptoms PCOS still remains elusive. Here, we showed an altered significantly correlated with phenotype. There were 33 patients (non-obese individuals, PN, n=12; obese PO, n=21) as well 15 control subjects CN, n=9; CO, n=6) enrolled our study. The plasma levels...
Akkermansia muciniphila is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes. However, whether A. can improve inflammatory bowel diseases (IBD), which a form of chronic intestinal dysbiosis, unknown. Hence, we used an isolated murine (designated 139) ATCC, to investigate their anti-inflammatory properties cell models Dextran Sulfate Sodium (DSS)-induced colitis mice. In vitro, the two strains exerted similar as they both reduced IL-8...