A5057754024- Laser Applications in Dentistry and Medicine
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Natural Antidiabetic Agents Studies
- Tendon Structure and Treatment
- Diabetes Treatment and Management
- dental development and anomalies
- Berberine and alkaloids research
- Dental Anxiety and Anesthesia Techniques
- Ginger and Zingiberaceae research
- Urinary Bladder and Prostate Research
- Pharmacological Effects of Natural Compounds
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Genetic and Kidney Cyst Diseases
- Cystic Fibrosis Research Advances
- TGF-β signaling in diseases
- Advanced Computational Techniques and Applications
- Hormonal Regulation and Hypertension
- Pomegranate: compositions and health benefits
- Medicinal Plant Extracts Effects
- Sunflower and Safflower Cultivation
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Urticaria and Related Conditions
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Guang’anmen Hospital
2014-2024
Shenyang Medical College
2024
Tianjin Stomatological Hospital
2021-2023
First Hospital of China Medical University
2022
China Academy of Chinese Medical Sciences
2014-2021
Harbin Medical University
2019-2020
Fourth Affiliated Hospital of Harbin Medical University
2019-2020
Beijing University of Chinese Medicine
2014-2018
Capital Medical University
2014-2015
ABSTRACT Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested hypothesis that alteration may be involved in alleviation T2DM with hyperlipidemia by metformin and specifically designed herbal formula (AMC). Four hundred fifty patients were randomly assigned to either metformin- or AMC-treated group. After 12 weeks treatment, 100 selected from each group assessed improvement. The...
Circular RNAs (circRNAs) are a novel type of noncoding and play important roles in tumorigenesis, including gastric cancer (GC). However, the functions most circRNAs remain poorly understood. In our study, we aimed to investigate new circRNA circ-DONSON GC progression. The expression tissues adjacent normal was analyzed by bioinformatics method, qRT-PCR, Northern blotting situ hybridization (ISH). effects on cell proliferation, apoptosis, migration invasion were measured using CCK8, colony...
In-depth profiling of genetic variations in the gut microbiome is highly desired for understanding its functionality and impacts on host health disease. Here, by harnessing long read advantage provided Oxford Nanopore Technology (ONT), we characterize fine-scale structural (SVs) hundreds microbiomes from healthy humans. ONT reads dramatically improve quality metagenomic assemblies, enable reliable detection a large, expanded set variation types (notably including large insertions...
Autoimmune thyroiditis (AIT), also known as Hashimoto's (HT), is an autoimmune disease that characterised by elevated thyroid-specific antibody titres. The incidence of AIT increasing year over year, making it urgent to establish a suitable animal model for this condition, in order better explore its pathogenesis and potential pharmaceutical mechanisms treatment. Owing lack basic research on disease, problems such disparate modelling methods with unclear varying success rates make difficult...
Background and Aim . Studies have shown an increasing number of type 2 diabetes (T2D) patients with concomitant obesity hyperlipidemia syndromes, resulting from relevant metabolic disorders. However, there are few medications therapies, which can thoroughly address these issues. Therefore, the current study evaluated efficacy safety using JTTZ, a Chinese herbal formula, to treat T2D hyperlipidemia. Methods A total 450 participants (HbA1c ≥ 7.0%; waist circumference 90 cm 80 in males females,...
Kinesin superfamily proteins (KIFs) can transport membranous organelles and protein complexes in an ATP-dependent manner. family member 15 (KIF15) is overexpressed various cancers. However, the function of KIF15 gastric cancer (GC) still unclear.GC patients' data from The Cancer Genome Atlas (TCGA) were analyzed by bioinformatics methods. expression was examined GC paracarcinoma tissues 41 patients to verify analysis results. relationship between clinical characteristics also observed...
Objective: Gegen Qinlian decoction (GQD) is a classical traditional Chinese medicine formulation which has been used for almost 2000 years. At Guang'anmen Hospital, Beijing, modified GQD version (mGQD) with seven instead of four herbal ingredients applied to treat Type 2 diabetes. Quality control crucial prerequisite the therapeutic application medicines. For identification products derived from GQD, Pharmacopeia requires analysis only three marker compounds. Because mGQD more complex...
This study aims to determine the effect of radial extracorporeal shock wave therapy (rESWT) versus drug when treating chronic pelvic pain syndrome (CPPS; type III B prostatitis). The included 45 participants with CPPS, divided into two groups: Group I comprised 25 participants, who were treated rESWT (3,000 pulses each; pressure: 1.8–2.0 bar; frequency: 10 Hz) once a week; II consisted 20 received combination an α-blocker and anti-inflammatory agent. Participants for 8 weeks. assessments...
Background . The study was designed to assess the efficacy and safety of Chinese herbal decoction in treating outpatients with T2DM. Methods All patients enrolled received for at least 6 months. primary outcome control rate HbA1c change HbA1c. FPG, 2hPG, HOMA-IR, HOMA- β were also collected evaluated. Results rates after treatment months 6, 12, 18, 24, 36, 48, 60 were<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn...
Urotensin II (UII) and its receptor (UTR) have mitogenic effects on tumor growth. Our previous study demonstrated that the UII/UTR system is up-regulated in dithyinitrosamine-induced precancerous rat liver lesions. However, role human hepatocellular carcinoma remains unknown. In this study, mRNA protein expression of UII samples BEL-7402 hepatoma cell line were evaluated. addition, effect exogenous pathways regulate proliferation cells vitro determined. Liver sections subjected to...
Background Pain physicians pay close attention to neuropathic pain (NP), since there is currently no ideal treatment. Radial shock wave therapy (RSWT) a noninvasive treatment chronic of soft tissue disorders. So far, information on the use RSWT for NP. Therefore we observe effects NP model induced by constriction injury (CCI) in rats. Methods Four different energy densities (1.0, 1.5, 2.0 and 2.5 bar) administered as single session or repeated sessions rats with CCI sciatic nerve. The...
This study aimed to assess efficacy and safety data from pilot trials of the radial extracorporeal shock wave therapy (rESWT) treat benign prostatic hyperplasia (BPH) refractory current medical therapy. A total 29 men with lower urinary tract symptoms (LUTS) suggestive BPH who had responded poorly for at least 6 months were poor surgical candidates enrolled. Each participant was treated rESWT once a week 8 weeks, each by 2000 impulses 2.0 bar 10 hertz frequency. International Prostate...
Clinicians agree that obtaining and retaining good treatment results for missing maxillary central incisors owing to trauma is not easy. Management of adult patients with permanent incisor loss who visit the clinic high expectations aesthetics function pose a significant diagnostic dilemma. Therefore, esthetic functional outcomes should be taken into consideration when deciding proper method. The described in this study aimed reestablish smile esthetics by proposing an effective...
Abstract Previous reports have established that rESWT fosters angiogenesis, yet the mechanism by which promotes cerebral angiogenesis remains elusive. stimulated HUVECs proliferation as evidenced CCK-8 test, with an optimal dosage of 2.0 Bar, 200 impulses, and 2 Hz. The tube formation assay revealed peaked at 36 h post-rESWT treatment, concurrent lowest expression level Bach1, detected both Western blot immunofluorescence. Wnt3a, β-catenin, VEGF also h. A Bach1 overexpression plasmid was...
Esophageal cancer is associated with high mortality rates and one of the cancers worst prognosis. Its incidence has significant regional specificity, particularly in China where it much higher than other countries. Moreover, effective diagnostic markers, therapeutic targets, molecular subtyping biomarkers are currently lacking for esophageal cancer. Nevertheless, large-scale omics studies have identified dozens robust genetic risk loci prognosis-related loci, drawn genomic, epigenomic,...
Huqi San (HQS) is a Chinese herbal preparation of eight medicinal herbs that promote diuresis, detoxification, blood circulation, and cholestasis. Defects in transporter expression function can cause cholestasis jaundice. However, the mechanism underlying HQS effects, especially on gastrointestinal tract ion secretion, has not been elucidated. Real-time RT-PCR Western blotting were used to study localization cystic fibrosis transmembrane conductance regulator (CFTR) α -ENaC rat alimentary...