A5100703015- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Economic and Financial Impacts of Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Protein Kinase Regulation and GTPase Signaling
- Cancer Immunotherapy and Biomarkers
- Mechanical Circulatory Support Devices
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Healthcare Systems and Reforms
- MRI in cancer diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aortic Disease and Treatment Approaches
- Pharmaceutical Practices and Patient Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetes Treatment and Management
- Patient Satisfaction in Healthcare
- Cancer, Hypoxia, and Metabolism
- Orthopaedic implants and arthroplasty
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
Nanjing Medical University
2016-2025
Changzhou No.2 People's Hospital
2024-2025
Nanjing Traditional Chinese Medicine Hospital
2024-2025
Nanjing Drum Tower Hospital
2021-2025
Nanjing University
2025
Changchun University of Chinese Medicine
2020-2025
Jiangsu Hengrui Medicine (China)
2016-2025
Hangzhou Hospital of Traditional Chinese Medicine
2025
Peking University
2024
Peking University Cancer Hospital
2024
Background In locally advanced rectal cancer (LARC), preoperative short-course radiotherapy (SCRT) with delayed surgery has been shown to be as effective long-course chemoradiotherapy, only modest benefits. This study aimed evaluate the efficacy and safety of SCRT combined subsequent CAPOX (capecitabine oxaliplatin) anti-PD-1 antibody camrelizumab in patients LARC. Methods was a prospective, single-arm, phase II trial. Treatment-naïve histologically confirmed T3-4N0M0 or T1-4N+M0...
KRAS mutation occurs in nearly 30% of human cancers, yet the most prevalent and oncogenic KRAS(G12D) variant still lacks inhibitors. Herein, we designed a series potent inhibitors that can form salt bridge with KRAS's Asp12 residue. Our ITC results show these have similar binding affinity both GDP-bound GTP-bound KRAS(G12D), our crystallographic studies reveal structural basis inhibitor binding-induced switch-II pocket experimentally confirming formation between piperazine moiety residue...
Background At high magnetic fields, degraded image quality due to dielectric artifacts and elevated specific absorption rate (SAR) are two technical challenges in fetal MRI. Purpose To assess the potential of constant (HDC) pad increasing decreasing SAR for 3 T Study Type Prospective. Field Strength/Sequence T. Balanced steady‐state free precession (bSSFP) single‐shot fast spin‐echo (SSFSE). Population One hundred twenty‐eight participants (maternal‐age 29.0 ± 3.6, range 20–40;...
The small GTP-binding protein Ras is pivotal in transmitting growth and differentiation signals downstream of cell surface receptors. Many observations have indicated that transmits from receptors into multiple pathways via direct interaction with different effectors mammalian cells. We identified a novel potential effector or target named Nore1. Nore1 has no significant sequence similarity to known proteins lacks an identifiable catalytic domain, but contains motifs predict DAG_PE binding...
Neurotoxic microglia and astrocytes begin to activate participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation SCI, but little is known about the underlying mechanism. Therefore, we aimed investigate whether PBM ameliorates modulating activation of SCI.Male Sprague-Dawley rats were randomly...
We have previously reported that electroacupuncture (EA) pretreatment induced tolerance against cerebral ischemic injury, but the mechanisms underlying this effect of EA are unknown. In study, we assessed on expression α7 nicotinic acetylcholine receptors (α7nAChR), using ischemia-reperfusion model focal ischemia in rats. Further, investigated role high mobility group box 1 (HMGB1) neuroprotection mediated by α7nAChR and EA.Rats were treated with at acupoint "Baihui (GV 20)" 24 h before...
The objective of our study was to compare the effectiveness microwave ablation (MWA) and multipolar radiofrequency (RFA) in vivo using two internally cooled probes.MWA (n=24) performed by simultaneous application double cooled-shaft antennae. Three power settings (60, 70, 80 W) were used. Multipolar RFA (n=16) also simultaneously bipolar applicators (lengths: 3-cm T30 4-cm T40) at 60 W. Probe spacing 2 cm. Each setting applied for eight ablations with a 10-minute duration each. probes...
China implemented the national drug price negotiation (NDPN) policy to include 17 innovative anticancer medicines in reimbursement list 2018. We aimed assess impact of this on utilization, cost, and accessibility medicines.We obtained monthly medicine procurement data from 1039 hospitals October 2017 December 2019. examined changes availability, defined daily dose cost (DDDc), affordability using descriptive statistics controlled interrupted time series analysis, measuring utilization by...
To evaluate the impact and cost-benefit value of pharmacist interventions for prophylactic antibiotic use in surgical patients undergoing clean or clean-contaminated operations.
Objective: The study aimed to evaluate the impact of National Health Insurance Coverage (NHIC) policy on utilisation and accessibility innovative anti-cancer medicines in Nanjing, China. Methods: We used adjusted World Organisation Action International methodology calculate price availability 15 included drug list 20 tertiary hospitals six secondary Nanjing before after NHIC implementation. Interrupted time-series regression was analyse changes medicines. Results: reduction rates ranged...
Recently, flipped classrooms (FCs) have gradually been used in Chinese higher education settings. However, few studies focused on the effects of FCs interdisciplinary curricula. The purpose this study was to examine impact an FC engagement, performance, and perceptions students teacher-student interaction a pharmaceutical marketing course.A clustered randomized controlled conducted, with 137 junior-year pharmacy undergraduates using serving as intervention group, contrast lecture-based...