A5087115660- Parkinson's Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Particle accelerators and beam dynamics
- Computational Drug Discovery Methods
- Genomics and Rare Diseases
- Particle Accelerators and Free-Electron Lasers
- Acute Lymphoblastic Leukemia research
- Neurological diseases and metabolism
- Childhood Cancer Survivors' Quality of Life
- Neurological disorders and treatments
- Iron Metabolism and Disorders
- Genetic factors in colorectal cancer
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Click Chemistry and Applications
- Nuclear Receptors and Signaling
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Transcranial Magnetic Stimulation Studies
- Genomic variations and chromosomal abnormalities
- Diabetes, Cardiovascular Risks, and Lipoproteins
Guangdong Province Women and Children Hospital
2016-2025
Women's Hospital, School of Medicine, Zhejiang University
2024
Zhujiang Hospital
2017-2024
Southern Medical University
2014-2024
Babraham Institute
2023
Songjiang District Central Hospital
2017-2022
First Affiliated Hospital Zhejiang University
2020-2022
Medical Genetics Center
2022
Zhejiang University
2003-2021
Sichuan University
2009-2019
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together fecal shotgun metagenomics, to show that select group SCFA-producing strains was promoted by dietary fibers most other potential producers were either diminished or unchanged patients T2DM. When the fiber-promoted...
Highlights•An overview of PanCancer Atlas analyses on oncogenic molecular processes•Germline genome affects somatic genomic landscape in a pathway-dependent fashion•Genome mutations impact expression, signaling, and multi-omic profiles•Mutation burdens drivers influence immune-cell composition microenvironmentSummaryThe Cancer Genome (TCGA) has catalyzed systematic characterization diverse alterations underlying human cancers. At this historic junction marking the completion over 11,000...
Activation of the fibroblast growth factor receptor FGFR4 by FGF19 drives hepatocellular carcinoma (HCC), a disease with few, if any, effective treatment options. While number pan-FGFR inhibitors are being clinically evaluated, their application to FGF19-driven HCC may be limited dose-limiting toxicities mediated FGFR1-3 receptors. To evade potential limitations inhibitors, we generated H3B-6527, highly selective covalent inhibitor, through structure-guided drug design. Studies in panel 40...
Immune evasion is a well-recognized hallmark of cancer and recent studies with immunotherapy agents have suggested that tumors increased numbers neoantigens elicit greater immune responses. We hypothesized the system presents common selective pressure on high mutation burden therefore mutations would be enriched in tumors. The JAK family kinases required for signaling host modulators tumor, stromal, cells. Therefore, we analyzed alterations this signature an mutation. Here, searched database...
Abstract Purpose This study aimed to evaluate the safety and efficacy of chimeric antigen receptor (CAR) disialoganglioside 2 (GD2)-specific (4SCAR-GD2) T cells for treatment refractory and/or recurrent neuroblastoma (NB) in pediatric patients. Experimental design A phase I clinical using 4SCAR-GD2 NB patients was conducted. registered at www.clinicaltrials.gov (NCT02765243). lentiviral CAR with signaling domains CD28/4-1BB/CD3ζ-iCasp9 transduced into activated cells. The response T-cell...
Background: Prenatal diagnosis of fetal short long bones (SLBs) was reported to be associated with skeletal dysplasias, chromosomal abnormalities, and genetic syndromes. This study aims identify the causes for bones, retrospectively evaluate additional diagnostic yield exome sequencing (ES) following use conventional testing. Methods: A cohort ninety-four fetuses sonographically identified analyzed by trio-exome between January 2016 June 2021. Fetuses abnormal results karyotype or microarray...
Abstract Background ALG8-congenital disorder of glycosylation (ALG8-CDG) is a rare inherited metabolic leading to severe multisystem manifestations, with no reported prenatal patients date. Methods We describe two fetuses from single family ALG8-CDG presenting hydrops, undergoing comprehensive ultrasound, umbilical cord blood biochemistry, autopsy, placental pathology, and genetic testing. Results Prenatal ultrasound revealed fetal skeletal anomalies, cardiac developmental abnormalities,...
Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) share several clinical neuropathologic features, studies suggest that gene mutations polymorphisms are involved in both conditions. Matrix metalloproteinase-9 (MMP-9) is implicated the pathogenesis of PD ALS, C(−1562)T polymorphism MMP-9 leads to higher promoter activity. We therefore investigated whether this predisposes sporadic ALS (sALS). Samples from 351 subjects with healthy controls two major cities China were compared,...
The study is aimed to investigate the pathogenesis underlying increased prevalence of thyroid nodule (TN) in different levels metabolic syndrome (MetS) components and analyze relationships between TN MetS components. A total 6,798 subjects, including 2201 patients with TN, were enrolled this study. Anthropometric, biochemical, ultrasonographic, other parameters all measured. There was obviously sexual difference (males 26.0%, females 38.5%, resp.). hyperuricemia (45.7% versus 37.4%, P =...
Background and purpose: Mutations in the glucocerebrosidase (GBA) gene have been implicated development of Parkinson’s disease (PD). However, recent screenings for GBA mutations PD subjects from different ethnic populations yielded contradictory results. Methods: We performed a case–control study to look possible association between N370S allele involving 628 two separate Chinese Han mainland China. All were successfully genotyped by polymerase chain reaction–restriction fragment length...
Background and purpose: The H63D polymorphism in the hemochromatosis ( HFE ) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) Europe America, but no data have Asia. Here, we investigated possible association between sporadic ALS (sALS) Chinese Han population. Methods: A total of 195 individuals with sALS from three centers China 405 unrelated healthy controls were recruited. All subjects genotyped by restriction fragment length (RFLP) analysis. Results:...
Phenotypic variations in α‐thalassemia mainly depend on the defective α‐globin gene number. Genetic modifiers of phenotype Hemoglobin H ( HbH ) disease were poorly reported, apart from β‐thalassemia allele that was identified ameliorating severity α‐thalassemia. Because erythroid Krüppel‐like factor KLF1 mutations can modulate red blood phenotype, we evaluated its effect phenotype. Overall, 72 subjects with five different heterozygous 1468 individuals, including 65 out 432 carriers fetal...
Abstract Peptidylarginine deiminase IV (PADI4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. Genetic or pharmacological PADI4 inhibition is therapeutically efficacious in mice, but no clinically relevant inhibitors currently exist. additionally mediates immune responses cellular reprogramming, although full extent its physiological roles unexplored. Despite detailed molecular knowledge activation vitro , we lack understanding...
Abstract Background The Southeast Asian deletion (-- SEA ) is the most commonly observed mutation among diverse α-thalassemia alleles in Asia and South China. It generally argued that -- , like other variants causing hemoglobin disorders, associated with protection against malaria endemic these regions. However, little evidence has been provided to support this claim. Results We first examined genetic imprint of recent positive selection on allele flanking sequences human α-globin cluster,...
Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) two COX genes in order to explaining association between these polymorphisms we also stroke risk determine whether gene-gene interaction increases or its subtypes.A total 1981 study subjects (1078 cases 903 control subjects) were recruited. The multiple factors was using Multifactor Dimensionality Reduction. additive...