A5038859783- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Periodontal Regeneration and Treatments
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Inflammatory mediators and NSAID effects
- Streptococcal Infections and Treatments
- Oral and gingival health research
- Cancer Research and Treatments
- Dental Health and Care Utilization
- Dental Radiography and Imaging
- Fungal Infections and Studies
- RNA modifications and cancer
- Immune Response and Inflammation
- Endodontics and Root Canal Treatments
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Dental Implant Techniques and Outcomes
- Estrogen and related hormone effects
- Cardiovascular Health and Risk Factors
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Northwest A&F University
2014-2025
Lanzhou University
2019-2025
Lanzhou University Second Hospital
2019-2025
Shanghai Sunshine Rehabilitation Center
2025
Shanghai Jiao Tong University
2025
Shanghai Ninth People's Hospital
2025
China Agricultural University
2025
State Key Laboratory of Oral Diseases
2008-2024
Abstract The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics pathological features underlying remain largely unknown. To characterize mechanisms pathogenesis in lung tissue using proteomic approach, fresh tissues were obtained from newly deceased patients pneumonia. After virus inactivation, quantitative approach combined bioinformatics analysis was used detect changes...
To evaluate the prevalence and incidence of periodontitis associated disability-adjusted life years (DALYs) from 1990 to 2019.We collected data on between 2019 Global Burden Disease (GBD) Study. The global prevalence, incidence, DALYs attributed were analyzed. age-standardized rate (ASR) estimated annual percentage changes (EAPCs) calculated quantify burden disease temporal trends.The ASR increased worldwide 2019. In 2019, Western Sub-Saharan Africa carried heaviest periodontitis, whereas...
Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in subchondral bone tissue of osteoarthritis (OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, identification novel drug targets PGE2 signaling progression urgently needed. Osteoclasts play critical role homeostasis and OA-related pain. mechanisms which regulates osteoclast function subsequently are largely...
Introduction Previous researches have often underestimated the diversity and combined effects of risk factors for Parkinson’s disease (PD). This study aimed to identify how multiple modifiable collectively impact PD. Methods The included 452,492 participants from UK Biobank, utilizing genetic data 255 phenotypic variables. A broad exposure association was conducted across seven domains: socioeconomic status, medical history, psychosocial factors, physical measures, early life, local...
Van Buchem disease is an autosomal recessive sclerosing bone dysplasia characterized by skeletal hyperostosis, overgrowth of the mandible, and a liability to entrapment seventh eighth cranial nerves. The genetic determinant maps chromosome 17q12-q21. We refined critical interval < 1-Mb region between D17S2250 D17S2253 in 15 affected individuals, all whom shared common haplotype. Furthermore, we report here identification 52-kb deletion located within encompassing D17S1789 that 100%...
Objective To examine the expression and changes in function of circulating CD 4+ CXCR 5+FoxP3+ follicular Treg (Tfr) cells patients with active rheumatoid arthritis ( RA ) stable remission, to clarify role Tfr pathogenesis . Methods Levels helper T (Tfh) peripheral blood 39 , 33 healthy controls were detected by flow cytometry. The was measured coculturing them Tfh B cells. Activated 45 −FoxP3 high also analyzed. Clinical indicators, including serum Ig autoantibody levels, tested,...
Abstract Periodontitis is a common type of inflammatory bone loss and risk factor for systemic diseases. The pathogenesis periodontitis involves dysregulation, which represents target new therapeutic strategies to treat periodontitis. After establishing the correlation cell-free DNA (cfDNA) level with in patient samples, we test hypothesis that cfDNA-scavenging approach will benefit treatment. We create nanoparticulate cfDNA scavenger specific by coating selenium-doped hydroxyapatite...
Background: Ulcerative colitis (UC) is an intestinal inflammatory disease that strongly associated with mitochondrial damage and dysfunction as well mitophagy lacks of satisfactory treatments.Hair follicle mesenchymal stem cell (HF-MSC)-derived exosomes owe benefit effectiveness on therapies.Hypoxia-preconditioned HF-MSCs exhibit enhanced proliferation migration abilities, their exert stronger effects than normal exosomes.However, the therapeutic function Hy-Exos in UC unknown.Methods: The...
ABSTRACT Aim This study aimed to evaluate and compare the results of combination therapy involving bone grafting two different resorbable collagen membranes in 1‐, 2‐ 3‐wall infrabony defects. Methods A total 174 patients with defects (≥ 7 mm periodontal probing depth) were randomized receive deproteinized bovine mineral (DBBM) either a native porcine non‐crosslinked membrane (N‐CM, control, n = 87) or novel crosslinked (C‐CM, test, 87). Clinical parameters, including depth (PPD), clinical...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding lymphoid tyrosine phosphatase LYP, has recently emerged as an important risk factor for human autoimmunity. Here we report that another missense substitution (R263Q) within catalytic domain of LYP leads to reduced activity. High-resolution structural analysis revealed molecular basis this loss function. Furthermore, Q263 variant conferred protection against systemic lupus erythematosus, reinforcing proposal inhibition...
Objective Microorganisms play a key role in the initiation and progression of periodontal disease. Research studies have focused on seeking specific microorganisms for diagnosing monitoring outcome periodontitis treatment. Large samples may help to discover novel potential biomarkers capture common characteristics among different patients. This study examines how screen merge high-quality periodontitis-related sequence datasets from several similar projects analyze mine information...
Periodontitis, an oral chronic inflammatory disease, is reported to show association with atherosclerotic vascular disease. Fusobacterium nucleatum commensal bacterium that abundantly implicated in various forms of periodontal diseases; however, its role the pathogenesis atherosclerosis unclear. This study aimed elucidate underlying pathogenic mechanisms induced by F. provide new insight on prevention and treatment atherosclerosis. We used animal model, is, ApoE-/- mice were infected gavage,...
In order to counter the common perception that molecular diagnostics are too complicated work in low resource settings, we have performed a difficult sample preparation and DNA amplification protocol using instrumentation designed be operated without wall or battery power. this combined nearly electricity-free nucleic acid extraction process with an isothermal assay detect presence of Clostridium difficile (C. difficile) stool infected patients. We used helicase-dependent (HDA) amplify...
Sustained and non-resolved inflammation is a characteristic of periodontitis. Upon acute inflammation, gingival fibroblasts release cytokines to recruit immune cells counter environmental stimuli. The intricate regulation pro-inflammatory signaling pathways, such as NF-κB, necessary maintain periodontal homeostasis. Nonetheless, how resolved has not yet been elucidated. In this study, 22 subtypes taste receptor family 2 (TAS2Rs), well the downstream machineries Gα-gustducin phospholipase...
Lung adenocarcinoma (LUAD) is amongst the major contributors to cancer-related deaths on a global scale. Adipocytokines and long non-coding RNAs (lncRNAs) are indispensable participants in cancer. We performed pan-cancer analysis of mRNA expression, single nucleotide variation, copy number prognostic value adipocytokines. LUAD samples were obtained from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases. Simultaneously, train, internal external cohorts grouped. After...