A5100419424- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Asthma and respiratory diseases
- RNA regulation and disease
- Lipid metabolism and disorders
- Natural product bioactivities and synthesis
- Photoreceptor and optogenetics research
- Nitric Oxide and Endothelin Effects
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Inflammatory mediators and NSAID effects
- Peroxisome Proliferator-Activated Receptors
- Ubiquitin and proteasome pathways
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Sesquiterpenes and Asteraceae Studies
Affiliated Hospital of North Sichuan Medical College
2025
North Sichuan Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Nanchang University
2021-2023
Qilu Hospital of Shandong University
2023
Henan Provincial People's Hospital
2022
Southwestern Medical Center
2021
Renmin Hospital of Wuhan University
2021
Wuhan University
2021
Abstract Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 associated with both lipid and glucose metabolism the liver. However, role metabolic progression HCC still to be elucidated. In present study, we found that highly expressed human as compared non-tumor hepatic tissue. overexpression promoted proliferation, migration, invasion, vivo tumor growth cells, whereas silencing had opposite...
Background: Ulcerative colitis (UC) is an intestinal inflammatory disease that strongly associated with mitochondrial damage and dysfunction as well mitophagy lacks of satisfactory treatments.Hair follicle mesenchymal stem cell (HF-MSC)-derived exosomes owe benefit effectiveness on therapies.Hypoxia-preconditioned HF-MSCs exhibit enhanced proliferation migration abilities, their exert stronger effects than normal exosomes.However, the therapeutic function Hy-Exos in UC unknown.Methods: The...
Purpose: Ocular neovascularization is a major cause of blindness. Although fibroblast growth factor-2 (FGF2) has been implicated in the pathophysiology angiogenesis, underlying mechanisms remain incompletely understood. The purpose this study was to investigate role FGF2 retinal and elucidate its mechanisms. Methods: oxygen-induced retinopathy mouse model used pathogenesis neovascularization. Immunofluorescence quantify retina. Data-independent acquisition proteomics were performed...
Abstract Purpose Retinoblastoma (RB) represents an adolescent eye malignancy. Long non-coding RNA (LncRNA) HOTAIR shows aberrant expression in many malignancies. This research investigated the mechanism of RB. Methods Normal retinal cell lines (ARPE-19 and RPE-1) RB (ORB50, Y79, HXO-RB44, WERI-RB) were selected for detection by qRT-PCR. sh-HOTAIR was delivered into Y79 HXO-RB44 cells. Cell-cycle distribution, proliferation, apoptosis detected CCK-8 assay flow cytometry. Binding relationships...
Brain cytoplasmic RNA 1 (BCYRN1), along non-coding RNA, plays a critical role in various diseases, including some cancers. However, the expression of BCYRN1 and its roles gastric carcinoma (GC) still remain unidentified. Thus, this study employed RT-qPCR to detect 85 paired GC samples adjacent normal tissues, performed vitro studies explore effects cells on cell proliferation, apoptosis migration. We found was significantly upregulated samples, positively correlated with advanced TNM stage...
Amlexanox, an anti-inflammatory agent, is widely used for treating aphthous ulcers. Recently, amlexanox has received considerable attention because of its efficacy in mitigating metabolic inflammation via directly suppressing IKKε/TBK1. However, the knockdown IKKε/TBK1 no effect on lipopolysaccharide (LPS)-primed RAW264.7 cells, mechanism against classical independent In this study, we aim to examine effects LPS-treated macrophages and a mouse model endotoxemia. We found that significantly...
48 different Pearson mutual-positive-correlation epidermal growth factor receptor (EGFR_1)-activatory molecular feedback, up- and down-stream network was constructed from 171 overlapping of 366 GRNInfer 223 under EGFR_1 CC ≥0.25 in high lung adenocarcinoma compared with low human normal adjacent tissues. Our identified inside-out upstream activated showed SLC2A1 (solute carrier family 2 (facilitated glucose transporter) member 1), CCNB2 (cyclin B2), HMMR (hyaluronan-mediated motility...
Müller glial cells (MGCs) are a group of in the retina that provide essential support to retinal neurons; however, understanding MGC apoptosis and autophagy remains limited. This study was aimed at investigating role MGCs under normal oxidative conditions, identifying underlying mechanisms. In addition, sirtuin 4 (SIRT4)-mediated signaling pathway observed regulate autophagic process MGCs. To assess effect on mitochondrial function survival, we treated rMC-1 cells-rat-derived cells-with...
Previously, using FREP-MS, we identified a protein complex including eight proteins that specifically bind to the functional SNP (fSNP) rs6032664 at CD40 locus associated with autoimmune diseases. Among these proteins, four are ribosomal RPL26, RPL4, RPL8, and RPS9 normally make up subunits involved in cellular process of translation. So far, no publication has shown function as transcriptional regulators. In this work, demonstrate proteins: bona fide regulators via binding rs6032664....
Objective: To study the anti-tumor effects of octreotide on A2780/Taxol ovarian cancer cells in vitro, and further explore its potential molecular mechanism. Materials Methods: Immunocytochemistry was performed to determine expression SSTR2 cells. Octreotide at different concentrations (0, 1.25, 2.5, 5.0, 10.0, 20.0 nmol/ml) were administrated vitro. CCK-8 assay used measure cell proliferation, cytometry determined apoptosis. The expressions MDR1, vascular endothelial growth factor (VEGF)...
Low-color-temperature light-emitting diodes (LEDs) (called 1900 K LEDs for short) have the potential to become a healthy light source due their blue-free property. Our previous research demonstrated that these posed no harm retinal cells and even protected ocular surface. Treatment targeting pigment epithelium (RPE) is promising direction age-related macular degeneration (AMD). Nevertheless, study has evaluated protective effects of on RPE. Therefore, we used ARPE-19 cell line zebrafish...
Abstract Introduction Immune thrombocytopenia (ITP) is a common acquired hemorrhagic disease without “gold standard” for the diagnosis, long non‐coding RNA (lncRNAs) can participate in regulating gene expression through various mechanisms and may play role immune intolerance ITP. Several previous studies have confirmed that lncRNA lncDC THRIL are involved development of autoimmune diseases. This study investigates relationship between levels two plasma lncRNAs (lncDC THRIL) clinical...
Abstract Glioma is the most important tumor of nervous system. LncRNA plays an role in occurrence, development, and metastasis glioma. The immune status glioma its treatment prognosis. In lower-grade (LGG), based on results Weighted correlation network analysis (WCGNA) lncRNA, we used lasso regression, random forest model, stepwise regression to establish lncRNA prognostic model: 0.58349*CYTOR + 0. 47804*LINC01831 24933*HOTAIRM1 73600*AC022034 62351*AC104407 = model prognosis score (LMPS)....
Abstract Protein hydroxylation is a post translational modification happens on various amino acids, which catalyzed by the oxoglutarate and oxygen dependent dioxygenases. The best characterized hydroxylated protein hypoxia inducible factor (HIF), degraded VHL/elongin C/elongin B/cullin 2/RBX1 (VCB/CR) E3 complex under normal conditions. Hypoxia or inhibitors (including FG4592 MK8617) of PHDs stabilize HIF1a regulate its downstream targets. Prolyl hydroxylase, including PHD2 PHD3 has been...