A5100636276- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Lipoproteins and Cardiovascular Health
- Extracellular vesicles in disease
- Immune cells in cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
- Hormonal Regulation and Hypertension
- Viral gastroenteritis research and epidemiology
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Nutrition, Genetics, and Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Natural Compounds in Disease Treatment
- Sexual Differentiation and Disorders
- Cardiac Ischemia and Reperfusion
- Cancer Research and Treatments
Shanghai University of Traditional Chinese Medicine
2025
Second Affiliated Hospital of Chongqing Medical University
2022
Affiliated Hospital of Guizhou Medical University
2020-2022
Guiyang Medical University
2020-2022
Chongqing Medical University
2018-2022
Dalian Medical University
2022
Guangxi Medical University
2019-2020
First Hospital of Jilin University
2020
Hunan Normal University
2020
Hunan Provincial People's Hospital
2020
Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-mediated immune suppression. Understanding the mechanisms leading functional reprogramming of macrophages in tumor microenvironment (TME) will benefit cancer immunotherapy. Herein, we find that scavenger receptor CD36 upregulated metastasis-associated (MAMs) deletion MAMs attenuates liver mice. contain more lipid droplets have unique capability engulfing cell-derived long-chain fatty acids, which are...
Abstract Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 associated with both lipid and glucose metabolism the liver. However, role metabolic progression HCC still to be elucidated. In present study, we found that highly expressed human as compared non-tumor hepatic tissue. overexpression promoted proliferation, migration, invasion, vivo tumor growth cells, whereas silencing had opposite...
(1) Background: Glycyrrhizic acid (GA) is the main component of traditional Chinese medicine Glycyrrhiza glabra. Many GA preparations in pharmaceutical market have good efficacy hepatoprotection and treatment liver diseases. However, pro-angiogenic effects for GA-based agents not been researched specifically. The aim this study was to investigate activity commonly used clinical practice screen representative angiogenesis promotor further elucidate mechanism action; (2) Methods: A zebrafish...
Numerous epidemiologic studies have found a close association between obesity and cancer. Dietary fat is fundamental contributor to risk factor for Thus far, the impact of dietary olive oil on cancer development remains inconclusive, little known about its underlying mechanisms. Nude mouse xenograft models were used examine effects high diet feeding cervical (CC) progression. Cell proliferation, migration invasion observed by methods EdU incorporation, Wound healing Transwell assay,...
Increasing evidence have shown that miRNAs play an important role in the development and progression of non-small cell lung cancer (NSCLC).In this study, we aimed to analyze serum exosomal miR-216b expression NSCLC patients its potential clinical significance.A total 105 60 healthy controls were enrolled, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed detect expression.The results demonstrated levels significantly lower compared controls. In addition,...
MicroRNAs (or miRNAs) are small non-coding RNAs (21-25 nucleotides) that involved in a wide range of activities related to the development and differentiation cells. Comparison miRNA expression profiles mouse P19 embryonic carcinoma cells with those differentiated neural stem showed level 65 miRNAs changed (2-fold) after differentiation. MiR-124a was dramatically upregulated (more than 20-fold) while miR-302 family miR-290-295 cluster were strongly down-regulated. Further analysis revealed...
To investigate the detailed mechanism of 3-iodothyronamine (T1AM) in cell apoptosis and programmed necrosis hypoxia/reoxygenation- (H/R-) induced H9C2 injury.Cardiomyocyte cells were cultured vitro for establishment cardiomyocyte H/R models. Cells randomly divided into four groups: control group, T1AM pretreatment (6 μm T1AM+H/R) group. The degree myocardial injury was determined by detection inhibition rate CCK8 lactic dehydrogenase (LDH) activity. Cell assessed through TUNEL assay flow...
Abstract Background The purpose of this study was to explore the potential molecular targets hyperlipidaemia and related mechanisms. Methods microarray dataset GSE66676 obtained from patients with downloaded. Weighted gene co-expression network (WGCNA) analysis used analyse expression profile, royal blue module considered have highest correlation. Gene Ontology (GO) functional Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses were implemented for identification genes in...
Objective To construct and identify the conditionally replicative adenovirus vectors which may induce human sodium iodide symporter (hNIS) expression in early region 1A (E1A) gene of telomerase reverse transcriptase (hTERT) glial fibrillary acidic protein (GFAP)promoter regions.Methods Immunoblotting assay was employed to detect variation GFAP prior following viral infection cerebral stellar glioblastoma cells (U87),neuroglioma (U251) embryonic lung fibroblasts (MRC-5) cells.The hTERT...
Abstract Background: The purpose of this study was to explore the potential molecular targets hyperlipidaemia and related mechanisms. Methods: microarray data set GSE66676 obtained from patients with downloaded. weighted gene co‑expression network (WGCNA) analysis used analyze expression profile royalblue module considered as highest correlation. Gene Ontology (GO) functional Kyoto Encyclopedia Genes genomes (KEGG) pathway enrichment analyses were implemented for identification genes in...
Abstract Background: The purpose of this study was to explore the potential molecular targets hyperlipidaemia and related mechanisms. Methods: microarray dataset GSE66676 obtained from patients with downloaded. Weighted gene co-expression network (WGCNA) analysis used analyse expression profile, royal blue module considered have highest correlation. Gene Ontology (GO) functional Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses were implemented for identification genes in...