Abstract This investigation seeks to dissect coronary artery disease molecular target candidates along with its underlying mechanisms. Data on patients CAD across three separate array data sets, GSE66360, GSE19339 and GSE97320 were extracted. The gene expression profiles obtained by normalizing removing the differences between important modules linked heart identified using weighted co-expression network analysis (WGCNA). Gene Ontology (GO) functional Kyoto Encyclopedia of Genes genomes...

The present study aimed to expound the association between XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles risk of coronary artery disease (CAD) ischemic stroke.The genetic makeup XKR6 SNP in 1783 unrelated participants (controls, 643; CAD, 588 stroke, 552) Han Chinese was obtained by Snapshot technology.The genotypic frequencies were disparate CAD (GG, 81.0%; GA/AA, 19.0%) or stroke 81.2%; 18.8%) patients healthy controls 85.7%, 14.3%; P <...

Abstract Background Little is known about the correlation between melanocortin 4 receptor gene ( MC4R ) single nucleotide polymorphisms (SNPs) and risk of obesity. This research sought to test rs17782313, rs476828 rs12970134 SNPs, their haplotypes gene-environment interactions on obesity in Maonan ethnic group, an isolated minority China. Methods A case-control study comprised 1836 participants (obesity 858; control 978) was conducted. Genotypes three SNPs were determined by next-generation...

This study investigated the association of NCAN-TM6SF2-CILP2-PBX4-SUGP1-MAU2 SNPs and gene-gene gene-environment interactions with serum lipid levels in population Southwest China.Genotyping 12 (i.e., rs2238675, rs2228603, rs58542926, rs735273, rs16996148, rs968525, rs17216525, rs12610185, rs10401969, rs8102280, rs73001065 rs150268548) was performed 1248 hyperlipidemia patients normal subjects.The allelic genotypic frequencies detected differed substantially between groups (P <...

Objective. Previous studies have shown inconsistent results in relation to the red cell distribution width (RDW), neutrophil lymphocyte ratio (NLR), and platelet (PLR) of atrial fibrillation (AF). This retrospective study is aimed at detecting association RDW, NLR, PLR with AF. Methods. A total 4717 critical care patients were screened from Medical Information Mart for Intensive Care- (MIMIC-) III database. The separated into non-AF AF groups. imbalances between groups reduced using...

Acute myocardial infarction (AMI) is a leading cause of death and not few these patients are combined with acidemia. This study aimed to detect the association acidemia short-term mortality AMI patients. A total 972 were selected from Medical Information Mart for Intensive Care (MIMIC) III database analysis. Propensity-score matching (PSM) was used reduce imbalance. Kaplan-Meier survival analysis compare mortality, Cox-proportional hazards model related factors associated mortality. After...

Abstract This study aimed to assess the relationship of 3 spectrin repeat containing nuclear envelope protein 1 ( SYNE1 ) and 4 KH domain RNA binding QK1 single nucleotide polymorphisms (SNPs), their haplotypes, gene‐gene (G × G), gene‐environment E) interactions hypercholesterolaemia (HCH) hypertriglyceridaemia (HTG) in Chinese Maonan minority. The genetic make‐up SYNE1‐QK1 SNPs 1932 unrelated subjects (normal, 641; HCH, 649; HTG, 642) was obtained by next‐generation sequencing...

The associations among the EH domain-binding protein 1 (EHBP1), tubulin beta class I (TUBB), and WW domain-containing oxidoreductase (WWOX) single nucleotide polymorphisms (SNPs) coronary artery disease (CAD) ischemic stroke (IS) are not yet understood. This study aimed to detect of these SNPs, gene-gene gene-environment interactions CAD IS in Guangxi Han population. A total 1853 unrelated subjects were recruited into normal control (n = 638), 622), 593) groups. Related genotypes determined...

The associations between single nucleotide polymorphisms (SNPs) rs2710642 and rs10496099 their effect on the EH domain-binding protein 1 (EHBP1) gene serum lipid profiles remain uncertain. This study was performed to investigate two EHBP1 SNPs in Han Maonan populations, including association, haplotypes, effects levels. Two 564 796 participants were genotyped by high-throughput sequencing, then genotype haplotype distributions of analyzed. Moreover, risk factors levels analyzed using...

This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) gene-environment E) interactions with hyperlipidaemia in Chinese Maonan minority. The genotypes 11 SNPs 912 normal 736 hyperlipidaemic subjects were detected next-generation sequencing technology. genotypic allelic frequencies rs1105056, rs10755582, rs2155510, rs9365344, rs11966842,...

Background: The association between the CYP17A1 and ATP2B1 SNPs essential hypertension (referred to as hypertension) is far from being consistent. In addition heterogeneity of resulting in inconsistent results, gene-gene gene-environment interactions may play a major role pathogenesis rather than single gene or environmental factor. Methods: A case-control study consisting 1,652 individuals (hypertension, 816; control, 836) was conducted Maonan ethnic minority China. Genotyping four...

In this study, we investigated associations between single nucleotide polymorphisms (SNPs) in the tubulin beta class I (TUBB) and WW domain-containing oxidoreductase (WWOX) genes, gene-gene interactions, gene-environment interactions dyslipidemia Chinese Maonan ethnic group. Four SNPs (rs3132584, rs3130685, rs2222896, rs2548861) were genotyped unrelated subjects with normal lipid levels (864) or (1129). While 5.0% of carried rs3132584TT genotype, none Han Beijing did. Allele genotype...

This study aimed to investigate the angiotensin converting enzyme (ACE) co-expression genes and their pathways involved in ST-segment elevation myocardial infarction (STEMI) at different time points.The array data set of GSE59867 was examined for ACE peripheral blood samples from 111 patients with STEMI four points (admission, discharge, 1 6 months after MI). Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment, Gene Ontology (GO) annotation protein-protein interaction (PPI) were...

This study is aimed at investigating natriuretic peptide B (NPPB) coexpression genes and their pathways involved in heart failure (HF) among patients both with without type 2 diabetes mellitus (T2DM).The microarray dataset GSE26887, containing 19 postischemic HF patients' peripheral blood samples (7 T2DM 12 T2DM), was examined to detect the coexpressed NPPB using corr.test function R packet. Furthermore, online analytical tools, we determined Kyoto Encyclopedia of Genes Genomes (KEGG)...

Background. Transforming growth factor beta-induced protein (TGFBI, encoded by TGFBI gene), is an extracellular matrix protein, widely expressed in variety of tissues. It binds to collagens type I, II, and IV plays important roles the interactions cell with cell, collagen, matrix. has been reported be associated myocardial fibrosis, latter pathophysiologyical basis atrial fibrillation (AF). However, mechanism AF remains unclear. We aimed detect potential via bioinformatics analysis. Methods....

Abstract Background The purpose of this study was to explore the potential molecular targets hyperlipidaemia and related mechanisms. Methods microarray dataset GSE66676 obtained from patients with downloaded. Weighted gene co-expression network (WGCNA) analysis used analyse expression profile, royal blue module considered have highest correlation. Gene Ontology (GO) functional Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses were implemented for identification genes in...

Abstract Background The current research was to assess the relationship of solute carrier family 44 member 4 ( SLC44A4 ) rs577272, notch receptor NOTCH4 rs3134931 SNPs and serum lipid levels in Han Maonan ethnic groups. Methods genetic makeup rs577272 2467 unrelated subjects (Han, 1254; Maonan,1213) obtained by using polymerase chain reaction restriction fragment length polymorphism technique, combined with gel electrophoresis, confirmed direct sequencing. Results genotype frequencies were...

The current study aims to further delineate the associations between synaptotagmin-like 3 ( SYTL3 ) and solute carrier family 22 member SLC22A3 single-nucleotide polymorphisms (SNPs) their haplotypes gene–gene (G × G)/environment E) interactions on risk of hyperlipidemia (HLP) in Maonan Han ethnic groups. Genotype distribution among SYTL3–SLC22A3 SNPs 2,829 individual patients bearing no relationship each other (Han, 1,436; Maonan, 1,393) was analyzed utilizing next-generation sequencing...

Abstract Background This study aimed to investigate natriuretic peptide B ( NPPB ) co-expression genes and the pathways involved in post-ischemic heart failure (HF) among patients both with without type 2 diabetes mellitus (T2DM). Methods The microarray dataset of GSE26887 was examined detect that co-expressed from 19 HF patients’ peripheral blood samples (7 T2DM 12 T2DM). were then screened using R packet. Further, online analytical tools, we determined Kyoto Encyclopedia Genes Genomes...

Abstract Background: The study aimed to detect the shared differentially expressed genes (DEGs) and specific DEGs of arrhythmogenic right ventricular cardiomyopathy (ARVC) dilated (DCM) as well their pathways. Methods: GSE29819 dataset was examined for ARVC vs. non-failing transplant donor hearts (NF), DCM NF, based on 6 patients with ARVC, 7 DCM, that were never actually transplanted. screened out using a Venn diagram. Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment, Gene...

Abstract Background: The purpose of this study was to explore the potential molecular targets hyperlipidaemia and related mechanisms. Methods: microarray data set GSE66676 obtained from patients with downloaded. weighted gene co‑expression network (WGCNA) analysis used analyze expression profile royalblue module considered as highest correlation. Gene Ontology (GO) functional Kyoto Encyclopedia Genes genomes (KEGG) pathway enrichment analyses were implemented for identification genes in...

Abstract Background： The study aimed to detect the shared differentially expressed genes (DEGs) and specific DEGs of arrhythmogenic right ventricular cardiomyopathy (ARVC) dilated (DCM) as well their pathways. Methods: GSE29819 dataset was examined for ARVC vs. non-failing transplant donor hearts (NF), DCM NF, based on 8 patients with ARVC, 7 DCM, 4 that were never actually transplanted. screened out using a Venn diagram. Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment, Gene...

Abstract Background: This study aimed to investigate natriuretic peptide B (NPPB) co-expression genes and the pathways involved in post-ischemic heart failure (HF) among patients both with without type 2 diabetes mellitus (T2DM). Methods: The microarray dataset of GSE26887 was examined detect that co-expressed NPPB from 19 HF patients’ peripheral blood samples (7 T2DM 12 T2DM). were then screened using R packet. Further, online analytical tools, we determined Kyoto Encyclopedia Genes Genomes...

Abstract Background: The purpose of this study was to explore the potential molecular targets hyperlipidaemia and related mechanisms. Methods: microarray dataset GSE66676 obtained from patients with downloaded. Weighted gene co-expression network (WGCNA) analysis used analyse expression profile, royal blue module considered have highest correlation. Gene Ontology (GO) functional Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses were implemented for identification genes in...