A5059576218- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Infective Endocarditis Diagnosis and Management
- NF-κB Signaling Pathways
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Hemodynamic Monitoring and Therapy
- Antibiotic Resistance in Bacteria
- Mast cells and histamine
- Vitamin D Research Studies
- Natural product bioactivities and synthesis
- Long-Term Effects of COVID-19
- Allergic Rhinitis and Sensitization
- Antifungal resistance and susceptibility
- Facial Trauma and Fracture Management
- Food Allergy and Anaphylaxis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Shanghai Jiao Tong University
2016-2025
Second Military Medical University
2023-2025
Changhai Hospital
2023-2025
Shanghai Institute of Materia Medica
2025
University of Chinese Academy of Sciences
2025
Sichuan University
2020-2024
Renji Hospital
2014-2024
China Medical University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Dalian Institute of Chemical Physics
2024
Nirmatrelvir-ritonavir has been authorized for emergency use by many countries the treatment of coronavirus disease 2019 (Covid-19). However, supply falls short global demand, which creates a need more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome 2 (SARS-CoV-2).We conducted phase 3, noninferiority, observer-blinded, randomized trial during outbreak caused B.1.1.529 (omicron) variant SARS-CoV-2. Symptomatic adults mild-to-moderate...
Abstract Background. The COVID-19 outbreak required the significantly increased working time and intensity for health professionals in China, which may cause stress signs. Methods. From March 2–13 of 2020, 4,618 China were included an anonymous, self-rated online survey regarding their concerns on exposure to outbreak. questionnaires consisted five parts: basic demographic information epidemiological exposure; occupational psychological impact; during episode; coping strategies; Huaxi...
Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for secondary infections during virus pandemics such coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and carbapenem-resistant Acinetobacter baumannii (CRAB) compassionate phage (at 2 successive doses of 109 plaque-forming unit phages). All our COVID-19-specific intensive care (ICU) CRAB...
Copper dioxide nanoparticles (NPs), which is a kind of important and widely used metal oxide NP, eventually reaches water body through wastewater urban runoff. Ecotoxicological studies this NPs effects on hydrophyte are very limited at present. Lemna minor was exposed to media with different concentrations CuO NPs, bulk CuO, two times concentration Cu2+ released from in culture media. The changes plant growth, chlorophyll content, antioxidant defense enzyme activities [i.e., peroxidase...
Coronavirus disease 2019 (COVID-19) has become a public health emergency. The reverse transcriptase real-time quantitative PCR (qRT-PCR) test is currently considered as the gold standard in laboratory for etiological detection of COVID-19. However, qRT-PCR results could be false-negative due to inadequate sensitivity qRT-PCR. In this study, we have developed and evaluated novel one-step single-tube nested (OSN-qRT-PCR) assay highly sensitive SARS-CoV-2 targeting ORF1ab N genes. OSN-qRT-PCR...
Background The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). therapeutic effect dexamethasone be related to its ability improve cortical function. Recent study showed that can reduce COVID-19 deaths by up one third in patients. aim this article is investigate whether SARS-CoV-2 attack adrenal cortex aggravate relative insufficiency. Methods We summarized clinical features reported currently available observational studies....
Interest in critical care-related artificial intelligence (AI) research is growing rapidly. However, the literature still lacking comprehensive bibliometric studies that measure and analyze scientific publications globally.The objective of this study was to assess global trends AI intensive care medicine based on publication outputs, citations, coauthorships between nations, co-occurrences author keywords.A total 3619 documents published until March 2022 were retrieved from Scopus database....
The thermal damage of diamond and the residual stress have always been critical issues to be resolved in development metal matrix composites. In presented study, FeCoCrNi high entropy alloys (HEAs)-diamond composites were fabricated by powder bed fusion-laser beam metals (PBF-LB/M), using un-coated Ti–Ni coated diamond, respectively. Based on numerical experimental analysis, effect thermal-mechanical behavior microstructures mechanical properties was systematically investigated. By...
Genkwanin is one of the major non-glycosylated flavonoids in many herbs with anti-inflammatory activities. Although its activity vivo has been reported, potential molecular mechanisms remain obscure. In this study, by pharmacological and genetic approaches, we explore effects genkwanin LPS-activated RAW264.7 macrophages. potently decreases proinflammatory mediators, such as iNOS, TNF-α, IL-1β IL-6, at transcriptional translational levels without cytotoxicity, indicating excellent potency...
Pulmonary fibrosis is characterized by lung fibroblast proliferation and collagen secretion. In lipopolysaccharide (LPS)-induced acute injury (ALI), aberrant of fibroblasts initiated in early disease stages, but the underlying mechanism remains unknown. this study, we knocked down Toll-like receptor 4 (TLR4) expression cultured mouse using TLR4-siRNA-lentivirus order to investigate effects LPS challenge on proliferation, phosphoinositide3-kinase (PI3K)-Akt pathway activation, phosphatase...
Abstract Objective To describe and evaluate the impact of diseases control prevention on epidemics dynamics clinical features SARS-CoV-2 outbreak in Shanghai. Design A retrospective descriptive study Setting China Participants Epidemiology information was collected from publicly accessible database. 265 patients admitted to Shanghai Public Health Center with confirmed COVID-19 were enrolled for analysis. Main outcome measure Prevention measures taken by government, epidemiological,...
Background: Coronavirus disease 2019 (COVID-19) is a global public health event without specific therapeutic agents till now. We aim to determine if high dose intravenous vitamin C (HDIVC) was effective for COVID-19 patients in severe condition. Methods: admitted Shanghai Public Health Clinical Center from January 22, 2020 April 11, were retrospectively scrolled. The enrolled those with confirmed diagnosis of or critical pneumonia, who received HDIVC within 24 hours after aggravation. Main...
Background Acute lung injury (ALI) is considered to be the major cause of respiratory failure in critically ill patients. Clinical studies have found that patients with sepsis and after hemorrhage, elevated level high mobility group box-1(HMGB-1) their circulation highly associated ALI, but underlying mechanism remains unclear. Extracellular HMGB-1 has cytokine-like properties can bind Toll-like Receptor-4 (TLR4), which was reported play an important role pathogenesis ALI. The aim this study...
Background: Studies have documented that older children and adolescents act as a reservoir of Bordetella pertussis infection for young infants who not yet completed their primary immunization schedule. Asymptomatic has been reported during outbreaks. This cross-sectional study aimed to investigate whether B. parapertussis can colonize the nasopharynx healthy school children, using culture pooled real-time PCR with targets insertion sequences IS481 IS1001. Methods: Nasopharyngeal (NP) swabs...